A5100353561- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Aquatic Ecosystems and Phytoplankton Dynamics
- Atmospheric chemistry and aerosols
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced biosensing and bioanalysis techniques
- Effects and risks of endocrine disrupting chemicals
- Enzyme Catalysis and Immobilization
- Marine and coastal ecosystems
- Air Quality and Health Impacts
- DNA and Biological Computing
- Phosphorus and nutrient management
- Retinoids in leukemia and cellular processes
- Carcinogens and Genotoxicity Assessment
- Cancer Risks and Factors
- Constructed Wetlands for Wastewater Treatment
- Maternal and fetal healthcare
- Congenital Diaphragmatic Hernia Studies
- Groundwater and Isotope Geochemistry
- Chemical Analysis and Environmental Impact
- COVID-19 Impact on Reproduction
- Luminescence and Fluorescent Materials
Nankai University
2020-2024
University of Technology Sydney
2022-2024
Suzhou Institute of Systems Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Yangzhou University
2024
University of California, San Francisco
2018-2023
Reproductive Science Center
2020-2023
Changjiang Institute of Survey, Planning, Design and Research
2023
Broad Center
2021
Huazhong Agricultural University
2014-2018
Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, levels protection provided their newborns through placental transfer antibodies. Here, we transplacental vaccine products functional anti-SARS-CoV-2 antibodies pregnancy early infancy in a cohort 20 individuals vaccinated late pregnancy. We find no evidence maternal blood, placenta tissue, or cord blood at delivery. However, time-dependent efficient IgG neutralizing neonate that...
In humans, a subset of placental cytotrophoblasts (CTBs) invades the uterus and its vasculature, anchoring pregnancy ensuring adequate blood flow to fetus. Appropriate depth is critical. Shallow invasion increases risk complications, e.g., severe preeclampsia. Overly deep invasion, hallmark placenta accreta spectrum (PAS), preterm delivery, hemorrhage, death. Previously rare condition, incidence PAS has increased 1:731 pregnancies, likely due rise in uterine surgeries (e.g., Cesarean...
Preeclampsia is a cardiovascular pregnancy complication characterised by new onset hypertension and organ damage or intrauterine growth restriction. It one of the leading causes maternal fetal mortality in globally. Short pre-term delivery fetus placenta, treatment options are limited. Consequently, preeclampsia leads to increased disease risk both mothers offspring later life. Here we aim examine impact reduced uterine perfusion pressure (RUPP) rat model on system, placental heart...
Despite gradual legislative efforts to phase out flame retardants (FRs) from the marketplace, polybrominated diphenyl ethers (PBDEs) are still widely detected in human maternal and fetal tissues, eg, placenta, due their continued global application consumer goods inherent biological persistence. Recent studies rodents placental cell lines suggest that PBDEs directly cause toxicity. During pregnancy, trophoblasts play key roles uterine invasion, vascular remodeling, anchoring of...
Although the ramifications associated with polybrominated diphenyl ethers (PBDEs) exposures during human pregnancy have yet to be determined, increasing evidence in humans and animal models suggests that these compounds cause neurodevelopmental toxicity. Human embryonic stem cells (hESCs) can used study effects of environmental chemicals throughout successive stages neuronal development. Here, using a hESC differentiation model, we investigated common PBDE congeners (BDE-47 or -99) on early...
Abstract Poly- and perfluroroalkylated substances (PFAS) are a major class of surfactants used in industry applications consumer products. Despite efforts to reduce the usage PFAS due their environmental persistence, compounds such as perfluorooctanoic acid (PFOA) widely detected human blood tissue. Although growing evidence supports that prenatal exposures PFOA other linked adverse pregnancy outcomes, target organs pathways remain unclear. Recent investigations mouse cell lines suggest may...
During human pregnancy, cytotrophoblasts (CTBs) from the placenta differentiate into specialized subpopulations that play crucial roles in proper fetal growth and development. A subset of these CTBs along an invasive pathway, penetrating decidua anchoring to uterus. hurdle pregnancy is ability cells migrate, invade remodel spiral arteries, ensuring adequate blood flow nourish developing fetus. Although advances continue describing molecular features regulating differentiation cells,...
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