A5056217010- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- Pregnancy and Medication Impact
- SARS-CoV-2 detection and testing
- Urticaria and Related Conditions
- linguistics and terminology studies
- Cancer Diagnosis and Treatment
- Reproductive tract infections research
- Management of metastatic bone disease
- Syphilis Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Biomedical Text Mining and Ontologies
- Hepatitis C virus research
- Medical Imaging and Pathology Studies
- Liver Disease Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
Fred Hutch Cancer Center
2023-2025
Amrita Vishwa Vidyapeetham
2023-2024
University of Washington
2023
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2023
University of California, San Francisco
2020-2022
Family Healthcare
2022
Jawaharlal Institute of Post Graduate Medical Education and Research
2021
ABSTRACT Background Serological tests are crucial tools for assessments of SARS-CoV-2 exposure, infection and potential immunity. Their appropriate use interpretation require accurate assay performance data. Method We conducted an evaluation 10 lateral flow assays (LFAs) two ELISAs to detect anti-SARS-CoV-2 antibodies. The specimen set comprised 128 plasma or serum samples from 79 symptomatic RT-PCR-positive individuals; 108 pre-COVID-19 negative controls; 52 recent individuals who underwent...
Objective To investigate maternal immunoglobulins’ (IgM, IgG) response to SARS-CoV-2 infection during pregnancy and IgG transplacental transfer, characterise neonatal antibody infection, longitudinally follow actively passively acquired antibodies in infants. Design A prospective observational study. Setting Public healthcare system Santa Clara County (California, USA). Participants Women with symptomatic or asymptomatic their infants were enrolled between 15 April 2020 31 March 2021....
Background Data regarding symptoms in the lactating mother-infant dyad and their immune response to COVID-19 mRNA vaccination during lactation are needed inform guidelines. Methods From a prospective cohort of 50 individuals who received mRNA-based vaccines for (mRNA-1273 BNT162b2), blood milk samples were collected prior first dose, immediately 2nd 4-10 weeks after dose. Symptoms mother infant assessed by detailed questionnaires. Anti-SARS-CoV-2 antibody levels measured Pylon 3D automated...
Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, levels protection provided their newborns through placental transfer antibodies. Here, we transplacental vaccine products functional anti-SARS-CoV-2 antibodies pregnancy early infancy in a cohort 20 individuals vaccinated late pregnancy. We find no evidence maternal blood, placenta tissue, or cord blood at delivery. However, time-dependent efficient IgG neutralizing neonate that...
Background: Bacterial vaginosis (BV) is a dysbiosis of the vaginal microbiome that prevalent among reproductive-age females worldwide. Adverse health outcomes associated with BV include an increased risk sexually-acquired HIV, yet immunological mechanisms underlying this association are not well understood. Methods: To investigate BV-driven changes to cervicovaginal tract (CVT) and circulating T cell phenotypes, Kinga Study participants or without provided (VT) ectocervical (CX) tissue...
Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there are limited data comparing vaccine- infection-induced neutralizing Abs (nAbs) against COVID-19 variants in mothers during pregnancy. We analyzed paired maternal cord plasma samples from 60 pregnant individuals. Thirty women vaccinated with mRNA vaccines (from December 2020 through August 2021) were matched 30 naturally infected March January by gestational age of exposure. Neutralization...
Vγ9Vδ2 T cells rapidly respond to phosphoantigens produced by Plasmodium falciparum in an innate-like manner, without prior antigen exposure or processing. Vδ2 have been shown inhibit parasite replication vitro and are associated with protection from P. parasitemia vivo. Although a marked expansion of is seen after acute malaria infection naïve individuals, repeated causes decline both frequency malaria-responsiveness, exhibit numerous transcriptional phenotypic changes, including...
Abstract Background Data regarding adverse events observed in the lactating mother-infant dyad and their immune response to COVID-19 mRNA vaccination during lactation are needed inform guidelines. Methods From a prospective cohort of 50 individuals who received mRNA-based vaccines for (mRNA-1273 BNT162b2), blood milk samples were collected prior first dose, immediately 2nd 4-10 weeks after dose. Symptoms mother infant assessed by detailed questionnaires. Anti-SARS-CoV-2 antibody levels...
Congenital cytomegalovirus (CMV) infection is the most common infectious cause of birth defects and neurological damage in newborns. Despite a well-established role for natural killer (NK) cells control CMV older children adults, it remains unknown whether fetal NK can sense respond to acquired utero.Here, we investigate impact congenital on neonatal NK-cell repertoire by assessing frequency, phenotype, functional profile cord blood samples from newborns with uninfected controls enrolled...
Chronic viral infections are known to lead T cell exhaustion or dysfunction. However, it remains unclear if antigen exposure episodes from periodic reactivation, such as herpes simplex virus type-2 (HSV-2) recrudescence, sufficient induce dysfunction, particularly in the context of a tissue-specific localized, rather than systemic, infection. We designed and implemented stringent clinical surveillance protocol longitudinally track both shedding situ tissue immune responses cohort HSV+...
Abstract OBJECTIVE To investigate maternal immunoglobulins’ (IgM, IgG) response to SARS-CoV-2 infection during pregnancy and IgG transplacental transfer, characterize neonatal antibody infection, longitudinally follow actively- passively-acquired antibodies in infants. DESIGN A prospective observational study. SETTING public healthcare system Santa Clara County (CA, USA). PARTICIPANTS Women with their infants were enrolled between April 15, 2020 March 31, 2021. OUTCOMES serology analyses the...
Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, levels protection provided their newborns through placental transfer antibodies. We evaluated transplacental vaccine products functional anti-SARS-CoV-2 antibodies pregnancy early infancy in a cohort 20 individuals vaccinated pregnancy. found no evidence maternal blood, placenta tissue, or cord blood at delivery. However, we time-dependent efficient IgG neutralizing neonate that...
Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, levels protection provided their newborns through placental transfer antibodies. We evaluated transplacental vaccine products functional anti-SARS-CoV-2 antibodies pregnancy early infancy in a cohort 20 individuals vaccinated pregnancy. found no evidence maternal blood, placenta tissue, or cord blood at delivery. However, we time-dependent efficient IgG neutralizing neonate that...
Abstract Bacterial vaginosis (BV) is a dysbiosis of the vaginal microbiome that prevalent in reproductive-age women worldwide. Adverse outcomes associated with BV include an increased risk sexually acquired Human Immunodeficiency Virus (HIV), yet immunological mechanisms underlying this association are not well understood. To investigate driven changes to cervicovaginal tract (CVT) and circulating T cell phenotypes, participants or without provided (VT) ectocervical (CX) tissue biopsies...
Non-Alcoholic Fatty Liver Disease (NAFLD) is a prevalent liver condition that necessi- tates accurate and non-invasive diagnostic approaches for effective treatment. This research addresses the challenges associated with present invasive procedures, such as biopsies, proposes novel tool. Inspired by limitations of existing methods, our project focuses on revolutionizing routine check-ups middle-aged individuals at risk NAFLD. Instead traditional tool recommends blood test, ensuring...
Abstract Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there is limited data comparing vaccine versus infection-induced nAb COVID-19 variants in mothers during pregnancy. We analyzed paired maternal cord plasma samples from 60 pregnant individuals. Thirty women vaccinated with mRNA vaccines were matched 30 naturally infected by gestational age of exposure. Neutralization activity against the five SARS-CoV-2 Spike sequences was measured a...
Abstract Background Congenital cytomegalovirus (CMV) infection is the most common infectious cause of birth defects and neurological damage in newborns. Despite a well-established role for NK cells control CMV older children adults, it remains unknown whether fetal can sense respond to acquired utero. Methods Here, we investigate impact congenital on neonatal cell repertoire by assessing frequency, phenotype, functional profile cord blood samples from newborns with uninfected controls...
Abstract Herpes simplex virus type-2 (HSV-2) is a lifelong, recurrent sexually transmitted infection that affects about 13% of the world population between ages 13–49. There currently no available vaccine for HSV-2 and understanding nuances cell-mediated immunity crucial to developing improved therapeutics vaccines. induces potent, localized type I interferon (TIIFN) signaling cascade can stimulate both innate adaptive antiviral effector responses. Interestingly, regulatory T cells (Tregs),...
Language barriers are a major problem in the healthcare industry because they restrict access to essential medical information, which prevents professionals from making well-informed decisions. The goal of this project is create solution that can overcome barrier. This utilises 3-step approach, combining Medical Term Translation API, Text Summarizer, and Browser Extension. integrated could enhance literacy help make decisions healthcare. large set users understand vital information also...
A 54-year-old male smoker presented with hemoptysis.His medical history was unremarkable.Computed tomography of the chest showed a nodule, 2.3 Â 1.0 cm in size, left upper lobe, along mediastinal lymphadenopathy.Bronchoscopic examination done.Advanced lung adenocarcinoma, cT1cN3M1b, stage IVB (Bra), diagnosed.The tumor positive score for PD-L1 40%-49%.After wholebrain irradiation, four cycles systemic chemotherapy cisplatin and pemetrexed were administered.Neurological symptoms improved...