A5090651528- Ovarian cancer diagnosis and treatment
- Intraperitoneal and Appendiceal Malignancies
- Endometrial and Cervical Cancer Treatments
- Renal cell carcinoma treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition and Health in Aging
- BRCA gene mutations in cancer
- Frailty in Older Adults
- Cervical Cancer and HPV Research
- Metabolism, Diabetes, and Cancer
- Gestational Trophoblastic Disease Studies
- Prenatal Screening and Diagnostics
- Cellular transport and secretion
- PARP inhibition in cancer therapy
- Omental and Epiploic Conditions
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Urinary and Genital Oncology Studies
- Ultrasound in Clinical Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Sirtuins and Resveratrol in Medicine
- Cancer Diagnosis and Treatment
- Endometriosis Research and Treatment
- Maternal and fetal healthcare
- Hair Growth and Disorders
Duke Medical Center
2021-2024
Duke University
2010-2024
Duke Cancer Institute
2019-2024
University of Iowa
2024
Cancer Institute (WIA)
2024
University of California, San Francisco
2015-2021
UCSF Helen Diller Family Comprehensive Cancer Center
2021
Gynecologic Oncology Group
2020
Stanford University
2012-2017
SUNY Downstate Health Sciences University
2015
The Sedlis criteria define risk factors for recurrence warranting post-hysterectomy radiation early-stage cervical cancer; however, these were defined squamous cell carcinoma (SCC) at an estimated of ≥30%. Our study evaluates and compares SCC compared with adenocarcinoma (AC) develops histology-specific nomograms to estimate guide adjuvant treatment.We performed ancillary analysis GOG 49, 92, 141, included stage I patients who surgically managed received no neoadjuvant/adjuvant therapy....
Insulin causes the exocytic translocation of GLUT4 glucose transporters to stimulate uptake in fat and muscle. Previous results support a model which TUG traps intracellular, insulin-responsive vesicles termed storage (GSVs). triggers cleavage release GSVs; then recycles through endosomes during ongoing insulin exposure. The C terminus binds GSV anchoring site comprising Golgin-160 possibly other proteins. Here, we report that is acetylated. C-terminal peptide bound Golgin-160-associated...
We assessed the efficacy of cediranib, olaparib, and cediranib/olaparib compared with standard-of-care chemotherapy (SOC) in platinum-resistant or platinum-refractory epithelial ovarian cancer (PROC).
To promote glucose uptake into fat and muscle cells, insulin causes the translocation of GLUT4 transporters from intracellular vesicles to cell surface. Previous data support a model in which TUG traps GLUT4-containing tethers them intracellularly unstimulated cells mobilizes this pool by releasing tether. Here we show that undergoes site-specific endoproteolytic cleavage, separates GLUT4-binding, N-terminal region C-terminal previously suggested bind an anchor. Cleavage is accelerated...
In humans, a subset of placental cytotrophoblasts (CTBs) invades the uterus and its vasculature, anchoring pregnancy ensuring adequate blood flow to fetus. Appropriate depth is critical. Shallow invasion increases risk complications, e.g., severe preeclampsia. Overly deep invasion, hallmark placenta accreta spectrum (PAS), preterm delivery, hemorrhage, death. Previously rare condition, incidence PAS has increased 1:731 pregnancies, likely due rise in uterine surgeries (e.g., Cesarean...
Importance Despite the absence of high-quality evidence its safety and effectiveness, minimally invasive surgery (MIS) is increasingly used to treat advanced epithelial ovarian cancer (EOC). Objective To assess feasibility conducting a full-scale randomized clinical trial (RCT) designed compare efficacy MIS vs laparotomy in patients with advanced-stage EOC complete or partial response neoadjuvant chemotherapy (NACT). Design, Setting, Participants This lead-in pilot phase LANCE (Laparoscopic...
Although omentectomy is part of the staging and treatment epithelial ovarian cancer (EOC), its performance in a patient with grossly normal omentum—acknowledging role debulking gross tumor deposits—has never been definitively shown to improve survival.Using Surveillance, Epidemiology, End Results data from 1998 2010, we identified patients EOC assessed their age, race, year diagnosis, grade, histologic subtype, International Federation Gynecology Obstetrics stage, lymph node dissection,...
Purpose.: Frequent, brief intermittent episodes of hypoxia (IH) during hyperoxia increase reactive oxygen species in the immature retina with compromised antioxidant systems, thus leading to oxygen-induced retinopathy (OIR). We examined hypothesis that early exposure a mimetic superoxide dismutase (SOD), first line defense against oxidative stress, will decrease IH-induced (ROS) and prevent severe OIR our rat model. Methods.: To test this hypothesis, newborn rats (P0) were exposed IH...
Biomineralization has mostly been studied in the class Anthozoa (Phylum Cnidaria), but very little is known about evolution of calcified skeleton Hydrozoa or processes leading to its formation. The here investigated hydrozoan family Hydractiniidae. A phylogenetic analysis ribosomal, mitochondrial, and nuclear-protein-coding DNA sequences supported two independent origins within Hydractiniidae indicates a case parallel evolution, as suspected Anthozoa. Neither led either speciose numerically...
To identify the differentiating features in clinical presentation, management, and maternal/fetal outcome complete hydatidiform mole coexistent fetus compared with placental mesenchymal dysplasia. Between 1997 2015, five women four dysplasia were managed at University of California San Francisco. Clinical analyzed previously published data. Of cases fetus, two had live births. β-hCG levels > 200,000 IU/L all cases. On imaging, a clear plane between cystic component placenta favored diagnosis...
•Pericardial effusion may be present early in the disease process patients with ovarian cancer.•Even a small pericardial become clinically apparent setting of concomitant pleural effusion(s).•Cardiac tamponade should considered differential diagnosis postoperative hemodynamic instability to facilitate timely intervention.
Purpose Human Papillomavirus (HPV) is a risk factor for anogenital and oropharyngeal dysplasias malignancies. Allogeneic bone marrow transplant recipients are at high persistent HPV-infection the complications related to this. The primary objective of this study was increase HPV vaccination rates within allogeneic population. Methods This prospective cohort performed between January May 2023 Duke Adult Blood Marrow Transplant Clinic. patients least 6 months post-transplant were approached....
Abstract Posttraumatic osteoarthritis (PTOA) is a well-recognized public health burden without any disease modifying treatment. This occurs despite noted advances in surgical care the past 50 years. Mitochondrial oxidative damage pathways initiate PTOA after severe injuries like intraarticular fracture that often require surgery and contribute to less may or not meniscal injuries. When considering mitochondrial redox environment of injured joint, we hypothesized activation heme metabolism,...