A5088498661- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Heme Oxygenase-1 and Carbon Monoxide
- 3D Printing in Biomedical Research
- Infection Control and Ventilation
- RNA Interference and Gene Delivery
- Advanced Radiotherapy Techniques
- Microfluidic and Bio-sensing Technologies
- Inhalation and Respiratory Drug Delivery
- Climate Change and Health Impacts
- Cancer Research and Treatments
- COVID-19 and healthcare impacts
- Glioma Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Neonatal Health and Biochemistry
- Molecular Communication and Nanonetworks
- Maternal and Perinatal Health Interventions
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Pickering emulsions and particle stabilization
- Venous Thromboembolism Diagnosis and Management
- Innovative Microfluidic and Catalytic Techniques Innovation
- Blood Coagulation and Thrombosis Mechanisms
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
University of Iowa
2021-2025
Massachusetts Institute of Technology
2020-2024
University of Iowa Hospitals and Clinics
2023
Harvard Affiliated Emergency Medicine Residency
2022
Brigham and Women's Hospital
2003-2022
Harvard University
2017-2022
Dana-Farber Brigham Cancer Center
2021-2022
Dana-Farber Cancer Institute
2021-2022
Massachusetts General Hospital
2017-2022
Koch Institute for Integrative Cancer Research At MIT
2022

 Exposure to airborne nanoparticles contributes many chronic pulmonary diseases. Nanoparticles, classified as anthropogenic and natural particles, fibers of diameters less than 100 nm, have unrestricted access most areas the lung due their size. Size relates deposition efficiency particle, with particles in nano-range having highest efficiencies. The can lead inflammation, epithelial injury, further fibrosis. Cases particle-induced fibrosis, namely pneumoconiosis, are mostly...
Tissue repair is often impaired in pathological states, highlighting the need for innovative wound-healing technologies. This study introduces composite hyaluronic acid gas-entrapping materials (GEMs) delivering carbon monoxide (CO) to promote wound healing pigs. These facilitate burst release followed by sustained of CO over 48 h. In a porcine full-thickness model, CO-GEMs significantly accelerated closure compared standard-of-care dressing (Tegaderm). Wound area with was 68.6% vs 56.8% on...
Polypyrrole (PPy) is an inherently conducting polymer that has shown great promise for biomedical applications within the nervous system. However, to effectively use PPy as a biomaterial implant, it important understand and reproducibly control electrical properties, physical topography surface chemistry of polymer. Although there much research published on in various applications, no systematic study linking methodologies used synthesis PPy's basic polymeric properties (e.g.,...
Responsive polymeric biomaterials can be triggered to degrade using localized environments found in vivo. A limited number of provide precise control over the rate degradation and release entrapped cargo yield a material that is intrinsically nontoxic. In this work, we designed nontoxic acid-sensitive based on silyl ether chemistry. host cross-linkers were synthesized molded into relevant medical devices, including Trojan horse particles, sutures, stents. The resulting devices engineered...
Novel treatment strategies, including nanomedicine, are needed for improving management of triple-negative breast cancer. Patients with cancer, when considered as a group, have worse outcome after chemotherapy than patients cancers other subtypes, finding that reflects the intrinsically adverse prognosis associated disease. The aim this study was to improve efficacy docetaxel by incorporation into novel nanoparticle platform taxane-resistant Rod-shaped nanoparticles encapsulating were...
Carbon monoxide (CO) has long been considered a toxic gas but is now recognized bioactive gasotransmitter with potent immunomodulatory effects. Although inhaled CO currently under investigation for use in patients lung disease, this mode of administration can present clinical challenges. The capacity to deliver directly and safely the gastrointestinal (GI) tract could transform management diseases affecting GI mucosa such as inflammatory bowel disease or radiation injury. To address unmet...
Abstract This work evaluates various techniques for the incorporation of poly(ethylene glycol) (PEG) onto biodegradable nanoparticles (NPs) poly(lactic‐ co ‐glycolic acid) (PLGA) or poly(lactic (PLA) with purpose providing a functional site surface conjugation targeting agents and improving properties. The compared were based on NP preparation blends PLGA poloxamer block copolymers PLGA/PLA PEG. Blending 407 resulted in latter to up 43 wt % content. Direct heterofunctional NH 2 ‐PEG‐COOH...
Local administration of cytotoxic drugs using iontophoresis results in drug accumulation and therapeutic efficacy mouse models pancreatic breast cancer favorable PK a large animal model.
Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric therapy microbubble infusion, are utilized improve the responses current standard-of-care therapies. However, key obstacles remain, in particular delivery of at appropriate dose with optimal pharmacokinetics. Toward overcoming these hurdles, gas-entrapping materials (GeMs) capable tunable release formulated. It is shown injection...
Diabetic wound healing is uniquely challenging to manage due chronic inflammation and heightened microbial growth from elevated interstitial glucose. Carbon monoxide (CO), widely acknowledged as a toxic gas, also known provide unique therapeutic immune-modulating effects. To facilitate delivery of CO, we have designed hyaluronic-acid-based CO gas-entrapping materials (CO-GEMs) for topical prolonged gas the bed. We demonstrate that CO-GEMs promote response in murine diabetic models...
In Brief Objective To estimate the incidence, timing, and associated clinical characteristics of objectively diagnosed pregnancy-associated venous thromboembolism. Methods We retrospectively reviewed thromboembolism cases (deep thrombosis pulmonary embolism) that occurred between 1978 1996. Study inclusion criteria required objective diagnosis with either Doppler ultrasound, venography, impedance plethysmography, angiography, ventilation-perfusion scanning, or computed tomography magnetic...
To compare the impact of respirator extended use and reuse strategies with regard to cost sustainability during COVID-19 pandemic.
Objective To develop and test a new reusable, sterilisable N95 filtering facepiece respirator (FFR)-comparable face mask, known as the Injection Molded Autoclavable, Scalable, Conformable (iMASC) system, given dire need for personal protective equipment within healthcare settings during COVID-19 pandemic. Design Single-arm feasibility study. Setting Emergency department outpatient oncology clinic. Participants Healthcare workers who have previously undergone fit testing. Interventions Fit...