A5066995427- Heme Oxygenase-1 and Carbon Monoxide
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Neonatal Health and Biochemistry
- Respiratory viral infections research
- Pelvic and Acetabular Injuries
- High Altitude and Hypoxia
- Biosensors and Analytical Detection
- Immune Response and Inflammation
- Effects of Radiation Exposure
- Alcohol Consumption and Health Effects
- Gut microbiota and health
- Nuclear Issues and Defense
- Cannabis and Cannabinoid Research
- Sepsis Diagnosis and Treatment
- Optimism, Hope, and Well-being
- Gene expression and cancer classification
- Thermal Regulation in Medicine
- Radiomics and Machine Learning in Medical Imaging
- Hydrogen's biological and therapeutic effects
- Hip and Femur Fractures
- COVID-19 diagnosis using AI
- Cardiac Arrest and Resuscitation
The Ohio State University Wexner Medical Center
2024-2025
Brigham and Women's Hospital
2025
The Ohio State University
2024
Beth Israel Deaconess Medical Center
2019-2022
Harvard University
2019-2022
Resolving the COVID-19 pandemic requires diagnostic testing to determine which individuals are infected and not. The current gold standard is perform RT-PCR on nasopharyngeal samples. Best-in-class assays demonstrate a limit of detection (LoD) ~100 copies viral RNA per milliliter transport media. However, LoDs currently approved vary over 10,000-fold. Assays with higher will miss more patients, resulting in false negatives. false-negative rate for given LoD remains unknown. Here we address...
Abstract Background Resolving the coronavirus disease 2019 (COVID-19) pandemic requires diagnostic testing to determine which individuals are infected with severe acute respiratory syndrome 2 (SARS-CoV-2). The current gold standard is perform reverse-transcription polymerase chain reaction (PCR) on nasopharyngeal samples. Best-in-class assays demonstrate a limit of detection (LoD) approximately 100 copies viral RNA per milliliter transport media. However, LoDs currently approved vary over...
Carbon monoxide (CO) has long been considered a toxic gas but is now recognized bioactive gasotransmitter with potent immunomodulatory effects. Although inhaled CO currently under investigation for use in patients lung disease, this mode of administration can present clinical challenges. The capacity to deliver directly and safely the gastrointestinal (GI) tract could transform management diseases affecting GI mucosa such as inflammatory bowel disease or radiation injury. To address unmet...
Purpose To evaluate and report the performance of winning algorithms Radiological Society North America Cervical Spine Fracture AI Challenge. Materials Methods The competition was open to public on Kaggle from July 28 October 27, 2022. A sample 3112 CT scans with without cervical spine fractures (CSFx) were assembled multiple sites (12 institutions across six continents) prepared for competition. test set had 1093 (private set: n = 789; mean age, 53.40 years ± 22.86 [SD]; 509 males; 304;...
Abstract The urgent need for large-scale diagnostic testing SARS-CoV-2 has prompted pursuit of sample-collection methods sufficient sensitivity to replace sampling the nasopharynx (NP). Among these alternatives is collection nasal-swab samples, which can be performed by patient, avoiding healthcare personnel and personal protective equipment. Previous studies have reached opposing conclusions regarding whether nasal concordant or discordant with NP. To resolve this disagreement, we compared...
The urgent need for large-scale diagnostic testing SARS-CoV-2 has prompted interest in sample collection methods of sufficient sensitivity to replace nasopharynx (NP) sampling. Nasal swab samples are an attractive alternative; however, previous studies have disagreed over how nasal sampling performs relative NP Here, we compared versus specimens collected by health care workers a cohort individuals clinically suspected COVID-19 as well reverse transcription (RT)-PCR-positive outpatients...
<h3>ABSTRACT</h3> <h3>BACKGROUND AND PURPOSE:</h3> The Radiological Society of North America has actively promoted artificial intelligence (AI) challenges since 2017. Algorithms emerging from the recent RSNA 2022 Cervical Spine Fracture Detection Challenge demonstrated state-of-theart performance in competition's dataset, surpassing results prior publications. However, their real-world clinical practice is not known. As an initial step towards goal assessing feasibility these models...
Physical exercise has profound effects on quality of life and susceptibility to chronic disease; however, the regulation skeletal muscle function at molecular level after remains unclear. We tested hypothesis that benefits are linked partly microtraumatic events result in accumulation circulating heme. Effective metabolism heme is controlled by Heme Oxygenase-1 (HO-1, Hmox1), we find mouse muscle-specific HO-1 deletion (Tam-Cre-HSA-Hmox1fl/fl) shifts proportion fibers from type IIA IIB...
Infection is a common complication of major trauma that causes significantly increased morbidity and mortality. The mechanisms, however, linking tissue injury to susceptibility infection remain poorly understood. To study this relationship, we present potentially novel murine model in which liver crush followed by bacterial inoculation into the lung. We find such both impaired clearance was associated with significant elevations plasma heme levels. While neutrophil (PMN) recruitment lung...
Machine-learning datasets are typically characterized by measuring their size and class balance. However, there exists a richer potentially more useful set of measures, termed diversity that incorporate elements' frequencies between-element similarities. Although these have been available in the R Julia programming languages for other applications, they not as readily Python, which is widely used machine learning, easily applied to machine-learning-sized without special coding...
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