A5081861895- Geophysics and Gravity Measurements
- Astrophysics and Cosmic Phenomena
- Ionosphere and magnetosphere dynamics
- Methane Hydrates and Related Phenomena
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Appendicitis Diagnosis and Management
- Bariatric Surgery and Outcomes
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Biliary and Gastrointestinal Fistulas
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Helicobacter pylori-related gastroenterology studies
- Diabetes Management and Research
- Diverticular Disease and Complications
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
Norfolk and Norwich University Hospital
2010-2024
University of East Anglia
2013-2024
Pacific Northwest National Laboratory
2012-2023
Queen's University
2023
Norfolk and Norwich University Hospitals NHS Foundation Trust
2008-2021
Institute of Nautical Archaeology
2019
Texas A&M University
2019
VA Greater Los Angeles Healthcare System
2016
StemMed (United States)
2013
Rochester Institute of Technology
2008-2010
Abstract Background This multicentre cohort study sought to define a robust pathological indicator of clinically meaningful response neoadjuvant chemotherapy in oesophageal adenocarcinoma. Methods A questionnaire was distributed 11 UK upper gastrointestinal cancer centres determine the use assessment chemotherapy. Records consecutive patients undergoing oesophagogastric resection at seven between January 2000 and December 2013 were reviewed. Pathological assessed using Mandard Tumour...
Abstract Background Abdominal pain of uncertain aetiology (non-specific abdominal pain; NSAP) is the commonest reason for emergency surgical admission. The aim this study was to examine role early laparoscopy in management NSAP. Methods Some 120 patients, admitted between November 1995 and October 1998 with acute aetiology, were randomized into two groups: group 1 had during first 18 h admission 2 close observation, conventional investigation intervention if signs peritonism developed....
Summary We describe a previously unreported test to confirm accurate needle placement in caudal epidurals. Of 26 patients undergoing epidural, 19 (73%) had correct as determined by epidurography. All of these positive‘whoosh' test. There were no false positives.
Methylation of CpG islands (CGIs) in the promoter regions tumour suppressor genes is common colorectal cancer and occurs also an age-dependent manner morphologically normal mucosa. In this study, we quantified level methylation six associated with Wnt signalling pathway (adenomatous polyposis coli, DKK1, WIF1, SFRP1, SFRP2 SFRP5) together long-interspersed nuclear element-1 as a surrogate for global methylation. DNA was analysed 260 individual crypts obtained from eight female patients no...
The following, from the 12th OESO World Conference: Cancers of Esophagus, includes commentaries on role nurse in preparation esophageal resection (ER); management patients who develop high-grade dysplasia after having undergone Nissen fundoplication; trajectory care for patient with cancer; influence site tumor choice treatment; best location esophagogastrostomy; chylous leak esophagectomy; optimal approach to manage thoracic operational surgery cardioesophageal crossing; advantages robot...
The oral manifestations are described of 43 patients with previously undiagnosed non-insulin dependent diabetes mellitus (NIDD) who presented to an Oral Medicine Unit in a 24-month period. diagnosis was confirmed by measurement fasting blood glucose and where necessary tolerance test. Sixteen had burning mouth syndrome, ten unusually prolonged fungal and/or bacterial infections, nine nonspecific condition such as altered taste, six mucosal lesion erosive lichen planus, one patient sialosis...
The aim was to compare the frequency of severe chronic pain that required attendance at a clinic after open and laparoscopic inguinal hernia repairs.This retrospective analysis 7999 patients who underwent repair between January 1994 December 2001. definition related surgery bad enough for patient seek further medical help be referred specialist exclusion surgically correctable pathology such as recurrence.During study there were 7153 repairs 846 repairs. Sixty-nine (1.0 per cent) median 16.9...
This qualitative study examined the medication-taking behaviors and attitudes of participants determined to be 100% adherers antiretroviral therapy from a NIH-funded testing 12-week telephone adherence intervention. Using open-ended questions, interviewers collected data on sample 13 informants, whose medication randomly selected was 100%, based 30-day collection using electronic event monitoring (EEM). The analysis revealed 'successful management' as core category or main theme. achieved...
Bulk acoustic wave (BAW) filters operating at center frequency of 3.7GHz, comprising BAW resonators utilizing single crystal aluminum nitride (AlN) piezoelectric films epitaxially grown on silicon carbide (SiC) substrates, are reported. Metal-organic chemical vapor deposition (MOCVD) growth was used to obtain AlN 150-mm diameter c-plane semi-insulating SiC substrates with (0004) X-ray diffraction (XRD) rocking curve full-width half-maximum (FWHM) 0.025°. The fabricated (1.25×0.9 sq.mm) had a...
Protein redox chemistry constitutes a major void in knowledge pertaining to photoautotrophic system regulation and signaling processes. We have employed chemical biology approach analyze sensitive proteins live Synechococcus sp. PCC 7002 cells both light dark periods, understand how cellular balance is disrupted during nutrient perturbation. The present work identified 300 putative redox-sensitive that are involved the generation of reductant, macromolecule synthesis, carbon flux through...
BackgroundLaparoscopic cholecystectomy (LC) can be technically challenging in the obese. The primary aim of trial was to establish whether following a Very Low Calorie Diet (VLCD) for two weeks pre-operatively reduces operation time. Secondary outcomes included perceived operative difficulty and length hospital stay.MethodsA single-blinded, randomized controlled consecutive patients with symptomatic gallstones BMI >30 kg/m2 46 were VLCD or normal diet prior LC. Food diaries used document...
The role of ischaemia in the pathogenesis acute pancreatitis is unknown. Some experimental studies have shown that has little effect on pancreas, while others found an association with pancreatic injury. Ischaemia-reperfusion damage been well documented other sites such as intestine, cardiac muscle, and skeletal muscle. However, injury usually seen only after complete ischaemia, which uncommon clinically. Experimental chronic characterized by low blood flow, interstitial pH, impaired tissue...
Over a 14-year period 34 patients were referred for surgical treatment of insulinoma. The diagnosis was confirmed by demonstrating hypoglycaemia with inappropriate hyperinsulinaemia during prolonged fasting. Selective visceral angiography localized 30 solitary benign insulinomas and two carcinomas. In islet cell hyperplasia, demonstrated single lesion only. Ultrasonography had sensitivity 15 per cent computed tomography 24 in the localization tumours. All but one treated operation. Eighteen...
High-fat diet (HFD) induced obesity and concomitant development of insulin resistance (IR) type 2 diabetes mellitus have been linked to mitochondrial dysfunction. However, it is not clear whether dysfunction a direct effect HFD, or if function reduced with increased HFD duration. We hypothesized that the oxidative lipid metabolism functions in skeletal muscle mitochondria for mice are similar, elevated, relative standard (SD) mice; thereby, IR neither cause nor consequence applied chemical...