A5000085679- Exercise and Physiological Responses
- Cardiovascular and exercise physiology
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Sports Performance and Training
- Heme Oxygenase-1 and Carbon Monoxide
- Autophagy in Disease and Therapy
- Cancer survivorship and care
- Genetics and Physical Performance
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Cardiovascular Effects of Exercise
- Neonatal Health and Biochemistry
- Muscle activation and electromyography studies
- Childhood Cancer Survivors' Quality of Life
- Nanoplatforms for cancer theranostics
- High Altitude and Hypoxia
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Dietary Effects on Health
- Inflammatory Biomarkers in Disease Prognosis
Beth Israel Deaconess Medical Center
2021-2025
Universidade de São Paulo
2015-2024
Hospital Sírio-Libanês
2021-2024
Hospital São Paulo
2021-2024
Harvard University
2021-2024
Instituto Butantan
2015
Skeletal muscle protein turnover is modulated by intracellular signaling pathways involved in synthesis, degradation, and inflammation. The proinflammatory status of cells, observed pathological conditions such as cancer, aging, sepsis, can directly modulate translation initiation proteolysis, contributing to negative turnover. In this context, branched-chain amino acids (BCAAs), especially leucine, have been described a strong nutritional stimulus able enhance attenuate proteolysis....
Increased cardiac sympathetic neuron (SN) activity has been associated with pathologies such as heart failure and hypertrophy, suggesting that innervation regulates cardiomyocyte trophism. Whether continuous input from the SNs is required for maintenance of size not determined thus far. To address role in regulation, we monitored effect pharmacological denervation mice on structure, function, signalling 24 h to 30 days absence other pathological stimuli. SN ablation caused an immediate...
Abstract Cardiac endoplasmic reticulum ( ER ) stress through accumulation of misfolded proteins plays a pivotal role in cardiovascular diseases. In an attempt to reestablish homoeostasis, the unfolded protein response UPR is activated. However, if persists, sustained activation leads apoptosis. There no available therapy for relief. Considering that aerobic exercise training AET attenuates oxidative stress, mitochondrial dysfunction and calcium imbalance, it may be potential strategy cardiac...
Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric therapy microbubble infusion, are utilized improve the responses current standard-of-care therapies. However, key obstacles remain, in particular delivery of at appropriate dose with optimal pharmacokinetics. Toward overcoming these hurdles, gas-entrapping materials (GeMs) capable tunable release formulated. It is shown injection...
The present investigation was undertaken to test whether exercise training (ET) associated with AMPK/PPAR agonists (EM) would improve skeletal muscle function in mdx mice. These drugs have the potential oxidative metabolism. This is of particular interest because fibers are less affected course disease than glycolitic counterparts. Therefore, a cohort 34 male congenic C57Bl/10J mice included this study randomly assigned into four groups: vehicle solution (V), EM [AICAR (AMPK agonist, 50...
We have recently demonstrated that NADPH oxidase hyperactivity, NF-κB activation, and increased p38 phosphorylation lead to atrophy of glycolytic muscle in heart failure (HF). Aerobic exercise training (AET) is an efficient strategy counteract skeletal this syndrome. Therefore, we tested whether AET would regulate redox balance protein degradation by decreasing hyperactivity reestablishing signaling, phosphorylation, proteasome activity plantaris myocardial infarcted-induced HF (MI) rats....
We tested the hypothesis that exercise training would attenuate metabolic impairment in a model of severe cancer cachexia.
Abstract Exercise training reduces the incidence of several cancers, but mechanisms underlying these effects are not fully understood. can affect spleen function, which controls hematopoiesis and immune response. Analyzing different cancer models, we identified that 4T1, LLC, CT26 tumor-bearing mice displayed enlarged (splenomegaly), exercise reduced mass toward control levels in two models (LLC CT26). also slowed tumor growth melanoma B16F10, colon 26 (CT26), Lewis lung carcinoma (LLC)...
The molecular mechanisms underlying skeletal muscle mitochondrial adaptations induced by aerobic exercise (AE) are not fully understood. We have previously shown that AE induces in cardiac muscle, mediated sympathetic stimulation. Since direct innervation of neuromuscular junctions influences homeostasis, we tested the hypothesis β2-adrenergic receptor (β2-AR)-mediated activation to muscle. Male FVB mice were subjected a single bout on treadmill (80% Vmax, 60 min) under β2-AR blockade with...
Increased proteolytic activity has been widely associated with skeletal muscle atrophy. However, elevated proteolysis is also critical for the maintenance of cellular homeostasis by disposing cytotoxic proteins and non-functioning organelles. We recently demonstrated that exercise activates autophagy re-establishes proteostasis in cardiac diseases. Here, we characterized impact on a model neurogenic myopathy induced sciatic nerve constriction rats. Neurogenic myopathy, progressive atrophy...
Abstract Skeletal myopathy is a hallmark of heart failure ( HF ) and has been associated with poor prognosis. other chronic degenerative diseases share common feature stressed system: sympathetic hyperactivity. Although beneficial acutely, hyperactivity one the main triggers skeletal in . Considering that β 2 ‐adrenoceptors mediate activity nervous system muscle, we presently evaluated contribution for morphofunctional alterations muscle also exercise intolerance induced by Male WT...
Background Doxorubicin and other anthracyclines are crucial cancer treatment drugs. However, they associated with significant cardiotoxicity, severely affecting patient care limiting dosage usage. Previous studies have shown that low carbon monoxide (CO) concentrations protect against doxorubicin toxicity. traditional methods of CO delivery pose complex challenges for daily administration, such as dosing To address these challenges, we developed a novel oral liquid drug product containing...
We tested the hypothesis that cancer cachexia progression would induce oxidative post-translational modifications (Ox-PTMs) associated with skeletal muscle wasting, different responses in muscles prevalence of glycolytic and fibers. used cysteine-specific isotopic coded affinity tags (OxICAT) gel-free mass spectrometry analysis to investigate cysteine Ox-PTMs profile proteome both plantaris (glycolytic) soleus (oxidative) tumor-bearing control rats. Histological revealed atrophy type II...
Aerobic exercise training (AET) has emerged as a strategy to reduce cancer mortality, however, the mechanisms explaining AET on tumor development remain unclear. Tumors escape immune detection by generating immunosuppressive microenvironments and impaired T cell function, which is associated with mitochondrial loss. improves content thus we tested whether would modulate metabolism in tumor-infiltrating lymphocytes (TIL). Balb/c mice were subjected treadmill protocol prior CT26 colon...
INTRODUÇÃO: São escassos os estudos quais verificaram efeitos do exercício físico sobre biomarcadores de estresse oxidativo e sua relação com o glicogênio muscular. OBJETIVO: O presente estudo verificou efeito treinamento aeróbio natação (TAN) oxidativo, conteúdo crescimento celular no músculo esquelético ratos. MÉTODOS: Dezoito ratos Wistar macho (60 dias) foram divididos em dois grupos: Grupo Sedentário (SG; n = 10): sedentários; Treinado (TG; 8): submetidos ao TAN (5,0 % peso corporal),...
β 2 ‐adrenergic receptor (β ‐ AR ) agonists have been used as ergogenics by athletes involved in training for strength and power order to increase the muscle mass. Even though anabolic effects of activation are highly recognized, less is known about impact endurance capacity. We presently mice lacking [β ‐knockout KO )] investigate role on exercise capacity skeletal metabolism phenotype. their wild‐type controls ( WT were studied. Exercise tolerance, fiber typing, capillary‐to‐fiber ratio,...