A5085219206- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Peripheral Artery Disease Management
- Cardiovascular Disease and Adiposity
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Ion channel regulation and function
- MicroRNA in disease regulation
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Nutrition and Health in Aging
- Healthcare and Venom Research
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- Cerebrovascular and Carotid Artery Diseases
- ATP Synthase and ATPases Research
- Thermoregulation and physiological responses
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular and exercise physiology
- Venomous Animal Envenomation and Studies
- Trypanosoma species research and implications
- Muscle metabolism and nutrition
- Cancer-related molecular mechanisms research
- Lipoproteins and Cardiovascular Health
Universidade de São Paulo
2014-2021
Increased proteolytic activity has been widely associated with skeletal muscle atrophy. However, elevated proteolysis is also critical for the maintenance of cellular homeostasis by disposing cytotoxic proteins and non-functioning organelles. We recently demonstrated that exercise activates autophagy re-establishes proteostasis in cardiac diseases. Here, we characterized impact on a model neurogenic myopathy induced sciatic nerve constriction rats. Neurogenic myopathy, progressive atrophy...
We tested the hypothesis that cancer cachexia progression would induce oxidative post-translational modifications (Ox-PTMs) associated with skeletal muscle wasting, different responses in muscles prevalence of glycolytic and fibers. used cysteine-specific isotopic coded affinity tags (OxICAT) gel-free mass spectrometry analysis to investigate cysteine Ox-PTMs profile proteome both plantaris (glycolytic) soleus (oxidative) tumor-bearing control rats. Histological revealed atrophy type II...
Crotoxin (CTX), the main neurotoxin from Crotalus durissus terrificus snake venom, has anti-inflammatory, immunomodulatory and antinociceptive activities. However, CTX-induced toxicity may compromise its use. Under this scenario, use of nanoparticle such as nanostructured mesoporous silica (SBA-15) a carrier might become feasible approach to improve CTX safety. Here, we determined benefits SBA-15 on CTX-related neuroinflammatory properties during experimental autoimmune encephalomyelitis...
Obesity is a risk factor associated with cardiometabolic complications. Recently, we reported that miRNA-22 deletion attenuated high-fat diet-induced adiposity and prevented dyslipidemia without affecting cardiac hypertrophy in male mice. In this study, examined the impact of obesogenic cardiovascular metabolic disorders females.Wild type (WT) knockout (miRNA-22 KO) females were fed control or an diet. Body weight gain, adiposity, glucose tolerance, insulin plasma levels total cholesterol...
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Background: Laser speckle contrast imaging allows non-invasive assessment of cutaneous blood flow. Although the technique is attractive to measure a quantity related skin flow (SBF) in anesthetized animal models, movements from breathing can mask SBF signal. As consequence, measurement overestimated because variable amount DC component due added Objective: To evaluate method for estimating background level signal, rejecting artefacts breathing. Methods: A baseline correction used accurate...