A5011727564- Adipose Tissue and Metabolism
- Drug Transport and Resistance Mechanisms
- Cholesterol and Lipid Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Pharmacogenetics and Drug Metabolism
- HIV/AIDS drug development and treatment
- Trypanosoma species research and implications
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Hormonal Regulation and Hypertension
- Muscle Physiology and Disorders
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Liver Disease Diagnosis and Treatment
- Ecology and Vegetation Dynamics Studies
- Cardiovascular Disease and Adiposity
- Insect symbiosis and bacterial influences
- Computational Drug Discovery Methods
- Helminth infection and control
- Birth, Development, and Health
- Muscle metabolism and nutrition
Hospital Israelita Albert Einstein
2025
Universidade de São Paulo
2015-2024
Beth Israel Deaconess Medical Center
2024
Harvard University
2024
Universidade Federal de Viçosa
2023
Laboratoire de Biodiversité et Biotechnologies Microbiennes
2021
Schneider Electric (France)
2019
Universidad de La Frontera
2016
Universidade Federal de São Paulo
2016
Fundação Getulio Vargas
2016
Exercise is known to improve cognitive functions and induce neuroprotection. In this study we used a short-term, moderate intensity treadmill exercise protocol investigate the effects of on usual markers hippocampal synaptic structural plasticity, such as synapsin I (SYN), synaptophysin (SYP), neurofilaments (NF), microtubule-associated protein 2 (MAP2), glutamate receptor subunits GluR1 GluR2/3, brain-derived neurotrophic factor (BDNF) glial fibrillary acidic (GFAP). Immunohistochemistry,...
We evaluated the effects of recreational football training combined with calorie‐restricted diet (football + diet) vs alone (diet) on aerobic fitness, lipid profile, and insulin resistance indicators in type 2 diabetes ( T D ) patients. Forty‐four patients aged 48–68 years (27 females, 17 males) were randomly allocated to group FDG ; n = 22) or DG 22), whom 19 15 subjects completed study. The was performed for 3 × 40 min/week 12 weeks. Dual‐energy X ‐ray absorptiometry scanning, treadmill...
The taxonomic and phylogenetic relationships of Trypanosoma vivax are controversial. It is generally suggested that South American, East West African isolates could be classified as subspecies or species allied to T. vivax. This the first study compare American (Brazil Venezuela) with West/East isolates. Phylogeny using ribosomal sequences positioned all tightly together on periphery clade containing Salivarian trypanosomes. same branching within was observed in inferred phylogenies...
There is a growing body of evidence that extracellular vesicles (EVs) and their cargo RNA, DNA, protein are released in the circulation with exercise might mediate interorgan communication. C57BL6/J male mice were subjected to diet-induced obesity aerobic training on treadmill for 8 wk. The effect was evaluated liver, muscle, kidney, white/brown adipose tissue. To provide new mechanistic insight, we profiled miRNA from serum EVs obese trained mice. We demonstrate changes circulating EV...
O objetivo do estudo foi avaliar os efeitos da execução imagética motora e facilitação neuromuscular proprioceptiva nas atividades corticais cerebrais em homens saudáveis. Métodos: 18 hígidos participaram de um protocolo randomizado, com IM, onde o participante imaginava movimento FNP ou realizava próprio ato motor, executando a diagonal FNP. Atividade cortical cerebral medida através eletroencefalografia repouso regiões frontais, centrais occipitais córtex durante 5 minutos antes após...
Abstract Background Transoesophageal Echocardiography (TOE) is semi-invasive examination used for cardiac evaluation, frequently associated to a certain degree of anxiety, and often requiring sedation patient comfort; alternatively, can result side effects such as hemodynamic changes (hypotension) or hypoventilation hypoxemia. Music has been non-pharmacological strategy reduce stress anxiety levels during medical procedures; accordingly, we hypothesized that music could be decrease and/or...
SUMMARY Blood examination by microhaematocrit and haemoculture of 459 snakes belonging to 37 species revealed 2·4% trypanosome prevalence in Viperidae ( Crotalus durissus Bothrops jararaca ) Colubridae Pseudoboa nigra ). Trypanosome cultures from C. P. were behaviourally morphologically indistinguishable. In addition, the growth morphological features a sand fly Viannamyia tuberculata similar those snake isolates. Cross-infection experiments lack host restriction, as 3 infected with ....
Aims: The relationship between variants in SLCO1B1 and SLCO2B1 genes lipid-lowering response to atorvastatin was investigated. Material Methods: One-hundred-thirty-six unrelated individuals with hypercholesterolemia were selected treated (10 mg/day/4 weeks). They genotyped a panel of ancestry informative markers for individual African component (ACA) estimation by SNaPshot® (c.388A>G, c.463C>A c.521T>C) (−71T>C) gene polymorphisms identified TaqMan® Real-time PCR. Results:...
ABSTRACT Several noncoding microRNAs (miR or miRNA) have been shown to regulate the expression of drug‐metabolizing enzymes and transporters. Xenobiotic drug‐induced changes in enzyme transporter may be associated with alteration miRNA expression. Therefore, this study investigated impact 19 xenobiotic drugs (e.g. dexamethasone, vinblastine, bilobalide cocaine) on ten miRNAs (miR‐18a, ‐27a, ‐27b, ‐124a, ‐148a, ‐324‐3p, ‐328, ‐451, ‐519c −1291) MCF‐7, Caco‐2, SH‐SY5Y BE(2)‐M17 cell systems....
High-fat diet (HFD) feeding causes insulin resistance (IR) in skeletal muscle of mice, which affects metabolism and function. The involvement muscle-specific microRNAs the evolution IR during 4, 8, 12 weeks HFD-induced obese mice was investigated. After 4 HFD, were obese, hyperglycemic, hyperinsulinemic; however, their muscles responsive to stimuli. Expressions MyomiRs (miR-1, miR-133a, miR-206) measured soleus not different from those found control mice. 8 HFD feeding, glucose uptake lower...
Polymorphisms in genes encoding for drug-metabolizing enzymes and drug transporters are among multiple factors that modulate the pharmacokinetic variability of tacrolimus (TAC) sirolimus (SRL). This study aimed to evaluate influence single nucleotide polymorphisms (SNPs) on TAC SRL dose-adjusted concentrations (C0/D) stable kidney transplant recipients.This is an exploratory prospective study, which includes 46 recipients. These patients were monitored from 3rd 24th month after...
The MDR1 gene encodes the P-glycoprotein, an efflux transporter with broad substrate specificity. P-glycoprotein has raised great interest in pharmacogenetics because it transports a variety of structurally divergent drugs, including lipid-lowering drugs. synonymous single-nucleotide polymorphism C3435T and nonsynonymous G2677T/A have been indicated as potential determinants variability drug disposition efficacy. In order to evaluate effect polymorphisms on serum levels lipids before after...
Physical exercise is known to enhance brain function in several aspects. We evaluated the acute effects of a moderate forced protocol on synaptic proteins, namely synapsin I (SYN) and synaptophysin (SYP), structural proteins (neurofilaments, NFs) rat regions related motor often affected by neurodegenerative disorders. Immunohistochemistry, Western blotting real-time PCR were used analyze expression those after 3, 7 15 days (EX3, EX7 EX15). In cerebellum, increase SYN was observed at EX15...
Despite the high efficacy of imatinib mesylate (IM) treatment for chronic myeloid leukemia (CML) patients, some individuals develop resistance due to impaired bioavailability. It has been previously demonstrated that haplotypes ATP-binding cassette subfamily B member 1 (ABCB1)with c.1236C>T, c.3435C>T and c.2677G>T/A polymorphisms markedly affect secondary structure ABCB1 mRNA its activity. These modifications may efflux transporter activity response with IM. The aim present study was...
The antioxidant and free radical scavenger properties of melatonin have been well described in the literature. In this study, our objective was to determine protective effect pineal gland hormone against DNA damage induced by cyclophosphamide (CP), an anti-tumor agent that is widely applied clinical practice. rats a single intraperitoneal injection CP (20 or 50 mg/kg). Animals received during dark period for 15 days (1 mg/kg drinking water). Rat bone marrow cells were used determination...
Polymorphisms in genes encoding transport proteins and metabolizing enzymes involved tacrolimus (TAC) disposition may be important sources of individual variability during treatment.The aim this study was to investigate the effect combined CYP3A4 CYP3A5 variants, using a CYP3A4/5 genetic score, ABCB1 polymorphisms on therapeutic TAC monitoring their relationship with clinical outcomes.Brazilian kidney transplant recipients (n=151), who received over 3 months after transplantation, were...
Nerve injury leads to a neuropathic pain state that results from central sensitization. This phenomenom is mediated by NMDA receptors and may involve the production of nitric oxide (NO). In this study, we investigated expression neuronal isoform NO synthase (nNOS) in spinal cord 3-month-old male, Wistar rats after sciatic nerve transection (SNT). Our attention was focused on dorsal part L3-L5 segments receiving sensory inputs nerve. SNT resulted development symptoms confirmed evaluating...