A5080573969- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Public Health in Brazil
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Estrogen and related hormone effects
- Genetic factors in colorectal cancer
- Drug Transport and Resistance Mechanisms
- Antioxidant Activity and Oxidative Stress
- Lipid metabolism and disorders
- Phytoestrogen effects and research
- Healthcare Regulation
- Genetic Associations and Epidemiology
- Agricultural and Food Sciences
- Pharmacogenetics and Drug Metabolism
- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- Healthcare during COVID-19 Pandemic
- Diet, Metabolism, and Disease
- Global Public Health Policies and Epidemiology
- Nitric Oxide and Endothelin Effects
- Diabetes Treatment and Management
- Menopause: Health Impacts and Treatments
- Nutrition, Genetics, and Disease
- Genomics and Rare Diseases
Instituto Dante Pazzanese de Cardiologia
2015-2025
PharmacoGenetics (China)
2024
Sociedade Brasileira de Diabetes
2022
Sociedade Brasileira de Cardiologia
2007-2017
Universidade Estadual de Campinas (UNICAMP)
2015
Hospital do Coração
2015
Universidade Federal de São Paulo
2015
Pontifícia Universidade Católica de Campinas
2015
Universidade de São Paulo
2003
Universidade Ibirapuera
1999
Nota: o conjunto de recomendações emitidas nesta Diretriz, forma geral, reflete as evidências
ALP -fosfatase alcalinaALT -alanina aminotransferase AMPK -proteína adenosina
Abstract Background Oxidative stress plays an important role in the pathophysiology of diabetes mellitus. The aim this study was to evaluate formation cholesterol oxides (ChOx) as biomarkers oxidative subjects with impaired glucose tolerance (IGT) and diabetes. Methods Blood plasma levels oxidation products were determined following groups: type 1 mellitus (DM1), 2 (DM2), (IGT), children without (C1) adults (C2). serum cholest‐5‐ene‐3α,7α‐diol (7α‐hydroxycholesterol, 7α‐OH),...
Aims: The relationship between variants in SLCO1B1 and SLCO2B1 genes lipid-lowering response to atorvastatin was investigated. Material Methods: One-hundred-thirty-six unrelated individuals with hypercholesterolemia were selected treated (10 mg/day/4 weeks). They genotyped a panel of ancestry informative markers for individual African component (ACA) estimation by SNaPshot® (c.388A>G, c.463C>A c.521T>C) (−71T>C) gene polymorphisms identified TaqMan® Real-time PCR. Results:...
The MDR1 gene encodes the P-glycoprotein, an efflux transporter with broad substrate specificity. P-glycoprotein has raised great interest in pharmacogenetics because it transports a variety of structurally divergent drugs, including lipid-lowering drugs. synonymous single-nucleotide polymorphism C3435T and nonsynonymous G2677T/A have been indicated as potential determinants variability drug disposition efficacy. In order to evaluate effect polymorphisms on serum levels lipids before after...
Justificativas A revisao da necessidade do jejum para determinacao perfil lipidico (colesterol total, LDL-C, HDL-C, nao-HDL-C e triglicerides [TG]) baseia-se nas seguintes justificativas: […] Posicionamento sobre a Flexibilizacao Jejum o Perfil Lipidico
Introdução A hipercolesterolemia familiar (HF) é uma causa genética comum de doença coronariana prematura, especialmente infarto do miocárdio, devido à exposição ao longo da vida a concentrações elevadas colesterol lipoproteína baixa densidade (LDL-c). Caracteriza-se por ser forma grave dislipidemia base genética, em que aproximadamente 85% dos homens e 50% das mulheres podem ter um evento coronariano antes completar os 65 anos idade, se não tratados adequadamente. HF considerada [...]
Background: Coadministration of any statin with ezetimibe is as effective using high doses the same in reduction low-density lipoprotein cholesterol (LDL-c). There may be other effects called pleiotropics. Objective: To compare effectiveness 2 different treatments that obtain equivalent LDL-c reductions (80 mg simvastatin, once a day and coadministration 10 simvastatin ezetimibe, day) over endothelial function inflammation. Methods: Twenty-three randomized patients hypercholesterolemia ×...
Hypercholesterolemia is linked to endothelial dysfunction and enhancement of the endogenous inhibitor NO synthase. The statins have lipid-lowering pleiotropic properties, which could exert protective effects on endothelium in hypercholesterolemia. association l -arginine with simvastatin promote a further improvement function this condition. Thus, we investigated whether simvastatin, or without supplementation -arginine, improve endothelium-dependent vasodilation. In study, 25...
Variability of response to statins has been related polymorphisms in genes involved cholesterol homeostasis and statin metabolism, such as CYP3A4 CYP3A5. We investigated the effects atorvastatin on CYP3A5 mRNA expression mononuclear cells CYP3A activity their interactions with common variants.Unrelated individuals (n=121) hypercholesterolemia (HC) were treated (10 mg/day/4 weeks). Ninety-two normolipidemic (NL) subjects selected a control group. Genotype analysis CYP3A4*1B (rs2740574),...