A5062793268- Cardiovascular and exercise physiology
- Physical Activity and Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Effects of Exercise
- Angiogenesis and VEGF in Cancer
- Obesity, Physical Activity, Diet
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Body Composition Measurement Techniques
- Mobile Health and mHealth Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Myeloid Leukemia Treatments
- Atherosclerosis and Cardiovascular Diseases
- Eosinophilic Disorders and Syndromes
- Health and Lifestyle Studies
- Cholesterol and Lipid Metabolism
- Cardiovascular Health and Risk Factors
- Seaweed-derived Bioactive Compounds
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Air Quality and Health Impacts
- Metabolism, Diabetes, and Cancer
- Behavioral Health and Interventions
- Phytochemicals and Antioxidant Activities
- Non-Invasive Vital Sign Monitoring
Universidade Federal de São Paulo
2015-2021
Cardiovascular Institute of the South
2016-2017
Centro Universitário Lusíada
2005-2013
University of Modena and Reggio Emilia
2012
Universidade de São Paulo
2005-2009
In-Q-Tel
2008
GTx (United States)
2008
Universidade Católica de Santos
2006
University of Turin
2006
Instituto do Coração
2004
Abstract Background Oxidative stress plays an important role in the pathophysiology of diabetes mellitus. The aim this study was to evaluate formation cholesterol oxides (ChOx) as biomarkers oxidative subjects with impaired glucose tolerance (IGT) and diabetes. Methods Blood plasma levels oxidation products were determined following groups: type 1 mellitus (DM1), 2 (DM2), (IGT), children without (C1) adults (C2). serum cholest‐5‐ene‐3α,7α‐diol (7α‐hydroxycholesterol, 7α‐OH),...
Protein-tyrosine phosphatases (PTPs) are important signaling enzymes that have emerged within the last decade as a new class of drug targets. It has previously been shown suramin is potent, reversible, and competitive inhibitor PTP1B Yersinia PTP (YopH). We therefore screened 45 analogs against panel seven PTPs, including PTP1B, YopH, CD45, Cdc25A, VHR, PTPα, LAR, to identify compounds with improved potency specificity. Of compounds, we found 11 inhibitory comparable or significantly...
The minimum amount of physical activity needed to obtain health benefits has been widely determined. Unlikely, the impact extreme amounts very vigorous (VVPA, ≥ 8 metabolic equivalents) heart remains controversial. We aimed evaluate dose-response relationship between VVPA and rate variability (HRV) in adults. selected 1040 asymptomatic individuals (60% women, 42 ± 15 years, 28 6 kg/m2) from Epidemiology Human Movement Study (EPIMOV). Participants remained supine position for 10 min, we an...
The sequential multiple assignment randomized trial (SMART) design allows for changes in the intervention during period. Despite its potential and feasibility defining best sequence of interventions, so far, it has not been utilized a smartphone/gamified physical activity.We aimed to investigate SMART assessing effects smartphone app improve activity adults. We also describe participants' perception regarding protocol use qualitatively.We conducted 24-week/two-stage which 18 insufficiently...
Summary. We treated 32 patients with Ph 1 ‐negative chronic myeloproliferative disorders (CMD) excessive thrombocytosis Interferon α‐2b (IFN α‐2b): 26 had essential thrombocythaemia, ET (18 previously untreated, eight pretreated); one thrombocythaemia after treatment for Hodgkin's disease (HD); two associated non‐Hodgkin's lymphoma (NHL); three stage II idiopathic myelofibrosis (IM). IFN was given at daily doses of 1−4 × 10 6 IU. Twenty‐seven (84%) responded, 17 (53%) achieved complete...
Insulin resistance (IR) and progressive pancreatic β-cell dysfunction have been identified as the two fundamental features in pathogenesis of obesity non-insulin-dependent diabetes mellitus. We aimed to investigate correlations between anthropometric indices IR non-diabetic obese individuals, cutoff value from receiver operating characteristic (ROC) curve analysis.Cross-sectional study conducted a private clinic.We included individuals (body mass index, BMI ≥ 30 kg/m2) with no mellitus...
To determine whether a restrictive pattern on spirometry is associated with the level of physical activity in daily life (PADL), as well cardiovascular disease (CVD) risk factors, asymptomatic adults.A total 374 participants (mean age, 41 ± 14 years) underwent spirometry, which included determination FVC and FEV1. A was defined an FEV1/FVC ratio > 0.7 < 80% predicted value. After conducting demographic, anthropometric, CVD assessments, we evaluated body composition, muscle function, postural...
Obese individuals have reduced performance in cardiopulmonary exercise testing (CPET), mainly considering peak values of variables such as oxygen uptake ([Formula: see text]), carbon dioxide production tidal volume (Vt), minute ventilation text]) and heart rate (HR). The CPET interpretation prognostic value can be improved through submaximal ratios analysis key like [Formula: text], text] efficiency slope (OUES). obesity influence on these responses has not yet been investigated. Our purpose...
To determine whether the level of physical activity in daily life (PADL) is associated with pulmonary function adult smokers.We selected 62 smokers from among participants an epidemiological study conducted city Santos, Brazil. The subjects underwent forced spirometry for assessment. PADL was assessed by International Physical Activity Questionnaire and triaxial accelerometry, device being used seven days. minimum PADL, terms quantity intensity, defined as 150 min/week moderate to vigorous...
Abstract Background We investigated whether adjuvant chemotherapy, extent of resection, and immunoistochemical neuroendocrine markers affected survival patients with the early stage large‐cell cancer. Methods This was a retrospective multicenter study including consecutive undergoing resection node negative carcinoma. Five‐year disease‐free rate were evaluated by Kaplan–Meier method log‐rank test in relation to (synaptophysin, chromogranin A, neuron‐specific enolase). Results Our population...
Objective We characterized the impact of metabolic syndrome (MetS) and its components on cardiovascular adverse events in patients with symptomatic chronic multivessel coronary artery disease, which have been followed prospectively for 2 years. Methods Patients enrolled MASS II study were evaluated each component MetS, as well full syndrome. Results The criteria MetS fulfilled 52% patients. presence (P<0.05), glucose intolerance (P=0.007), diabetes (P=0.04) was associated an increased...
Abstract Introduction: Physiological responses to the 6-min walk test (6MWT) have been increasingly evaluated in patients with cardiopulmonary diseases. However, previous studies did not include healthy persons. Objective: To evaluate intensity of 6MWT, develop a series predictive equations for physiological variables and their reliability middle-aged older adults. Method: We 102 non-trained adults (54 women, aged 61 ± 10 years) cross-validation sample 30 participants. measured 6MWT exercise...
Accelerometry provides objective measurement of physical activity levels, but is unfeasible in clinical practice. Thus, we aimed to identify fitness tests capable predicting inactivity among adults.Diagnostic test study developed at a university laboratory and diagnostic clinic.188 asymptomatic subjects underwent assessment levels through accelerometry, ergospirometry on treadmill, body composition from bioelectrical impedance, isokinetic muscle function, postural balance force platform...
To investigate the effects of low concentrations oxidized LDL (oxLDL) on proliferation and spontaneous motility human coronary artery endothelial cells (HCAEC) in culture.Cultures HCAEC were treated with native (nLDL) isolated from plasma minimally through different chemical methods; compared.Native had no deleterious vitro HCAEC; however, at its highest concentration for a longer exposure, nLDL inhibited cell proliferation. The chemically by spermine nonoate (SNO) 3-morpholinylsydnonimine...