A5083596171- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Morphological variations and asymmetry
- Atrial Fibrillation Management and Outcomes
- Elasticity and Material Modeling
- Antiplatelet Therapy and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Liver Disease and Transplantation
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Cardiac tumors and thrombi
- Porphyrin Metabolism and Disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Folate and B Vitamins Research
- Image Processing and 3D Reconstruction
- Advanced MRI Techniques and Applications
- Takotsubo Cardiomyopathy and Associated Phenomena
- Retinoids in leukemia and cellular processes
University of Perugia
2024
Leeds Teaching Hospitals NHS Trust
2022-2023
University of Leeds
2022-2023
Sapienza University of Rome
2013-2022
European Society of Cardiology
2022
Policlinico Umberto I
2012-2022
Sociedade Brasileira de Anestesiologia
2015
Tufts Medical Center
2008
Policlinico San Matteo Fondazione
1989-1990
University of Pavia
1989-1990
PURPOSE To evaluate, in a prospective trial, new combination chemotherapy specifically designed for elderly patients. PATIENTS AND METHODS From October 1988 to December 1990, 60 previously untreated patients older than years of age with aggressive non-Hodgkin's lymphoma (NHL) were treated at our institution weekly alternating six-drug regimen, P-VABEC. The schedule consisted doxorubicin, etoposide, and cyclophosphamide alternated vincristine bleomycin. Oral prednisone was administered daily...
Cirrhotic cardiomyopathy (CC) may interact with the clinical course of cirrhosis and can be implicated in development several complications advanced liver disease. The best easiest parameters which should define a condition reduced cardiac reserve are still controversial. This study was aimed at selecting parameters, derived by Doppler echocardiography, predictive survival during follow-up.This included cirrhotic patients without cardiovascular or pulmonary diseases. Patients were studied...
Anthracycline chemotherapy remains a critical component of cancer treatment despite its established risk cardiotoxicity. To investigate whether the AIDA protocol, which combines idarubicin, mitoxantrone, and all-trans retinoic acid (ATRA) for acute promyelocytic leukemia (APL) results in late cardiotoxicity, 34 APL patients long-term remission were evaluated. The cumulative dose idarubicin mitoxantrone 80 mg/m(2) 50 mg/m(2), respectively. Median follow-up was 7 years. Segmental wall motion...
The aim of this study is to investigate human left ventricular heart morphological changes in time among 17 healthy subjects. Preliminarily, 2 patients with volumetric overload due aortic insufficiency were added our analyses. We propose a special strategy compare the shape, orientation and size cardiac cycle's trajectories time. used 3D data obtained by Speckle Tracking Echocardiography order detect semi-automated homologous landmarks clouds as proxies morphology. An extended Geometric...
Summary. We treated 32 patients with Ph 1 ‐negative chronic myeloproliferative disorders (CMD) excessive thrombocytosis Interferon α‐2b (IFN α‐2b): 26 had essential thrombocythaemia, ET (18 previously untreated, eight pretreated); one thrombocythaemia after treatment for Hodgkin's disease (HD); two associated non‐Hodgkin's lymphoma (NHL); three stage II idiopathic myelofibrosis (IM). IFN was given at daily doses of 1−4 × 10 6 IU. Twenty‐seven (84%) responded, 17 (53%) achieved complete...
The assessment of left ventricular shape changes during cardiac revolution may be a new step in clinical cardiology to ease early diagnosis and treatment. To quantify these changes, only point registration was adopted neither Generalized Procrustes Analysis nor Principal Component were applied as we did previously study group healthy subjects. Here, extend patients affected by hypertrophic cardiomyopathy the original approach preliminarily include genotype positive/phenotype negative...
Abstract The function of left atrium (LA) is closely related to LA remodeling and one the most important mechanisms an increased deposition fibrous tissue that often basis for electro-mechanical changes before onset atrial fibrillation (AF). This study evaluated shape function, by investigating standard novel strain parameters calculated a new approach based on homologous times derived from 3D speckle tracking echocardiography (3DSTE) in hypertensive (HT) paroxysmal (PAF) patients with or...
Background Glutathione is a water-soluble tripeptide with potent oxidant scavenging activity. We hypothesized that glutathione administration immediately before and after primary angioplasty (primary percutaneous coronary intervention) could be effective in modulating immune cell activation, thereby preventing infarct expansion. Methods Results One hundred consecutive patients ST-segment-elevation myocardial infarction, scheduled to undergo intervention were randomly assigned the receive an...
The prescription of aspirin (acetylsalicylic acid (ASA)) to patients with a history hypersensitivity this drug could prove harmful. aim the study was assess antiplatelet activity and safety combined treatment indobufen clopidogrel in acute coronary syndrome (ACS) aspirin, undergoing stenting. Forty-two consecutive ACS treated stent implantation were randomly assigned receive 75 mg daily (loading dose 300 mg) plus 100 twice day (group A), or daily, after loading B). Platelet monitored both...
Abstract Left ventricle and left atrium are have been practically always analyzed separately in common clinically non-clinically oriented cardiovascular investigations. Both classic speckle tracking echocardiographic data contributed to the knowledge about deformational impairments occurring systo-diastolic differences. Recently new trajectory based approaches allowed a greater awareness entire or revolution on their deficiencies that take place presence of hypertrophic cardiomyopathy....
We characterized motion attributes arising from LV spatio-temporal analysis of distributions in myocardial infarction. Time-varying 3D finite element shape models were obtained 300 Controls and patients with Inter-individual left ventricular differences eliminated using parallel transport to the grand mean all cases. The first three principal component (PC) scores used characterize trajectory attributes. Scores tested ANOVA/MANOVA patient disease status (Infarcts vs. Controls) as a factor....