A5065465503- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Logic, Reasoning, and Knowledge
- Chronic Myeloid Leukemia Treatments
- Semantic Web and Ontologies
- CNS Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Logic, programming, and type systems
- Multi-Agent Systems and Negotiation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Formal Methods in Verification
- Lung Cancer Treatments and Mutations
- Advanced Database Systems and Queries
- CAR-T cell therapy research
- Eosinophilic Disorders and Syndromes
- Business Process Modeling and Analysis
- Sarcoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced Algebra and Logic
- Cardiac tumors and thrombi
- Hematopoietic Stem Cell Transplantation
- Microtubule and mitosis dynamics
- Cutaneous lymphoproliferative disorders research
Policlinico Umberto I
2004-2025
Sapienza University of Rome
2016-2025
Polo d’Innovazione di Genomica
2024
University of Bologna
2004-2022
Istituto di Ematologia di Bologna
2006-2022
University of Genoa
2004-2018
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2015
Policlinico S.Orsola-Malpighi
2005-2014
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2013
European Institute of Oncology
2009-2013
The aim of the F2 study was to verify whether a prospective collection data would enable development more accurate prognostic index for follicular lymphoma (FL) by using parameters which could not be retrospectively studied before, and choosing progression-free survival (PFS) as principal end point.Between January 2003 May 2005, 1,093 patients with newly diagnosed FL were registered 942 individuals receiving antilymphoma therapy selected population. variables we used score definition means...
To determine clinical features and patterns of outcome primary testicular diffuse large B-cell lymphomas (DLCL).A retrospective international survey 373 patients with DLCL.Most presented localized disease (stage I to II), the median age at diagnosis was 66 years (range, 19 91 years). Anthracycline-based chemotherapy administered 255 (68%), prophylactic intrathecal given 68 (18%); 133 (36%) received scrotal radiotherapy. Median overall survival 4.8 years, progression-free 4 years. The curves...
Purpose Apart from localized gastric disease, there is no consensus on standard initial treatment of mucosa-associated lymphoid tissue lymphoma. The IELSG-19 study (Randomized Trial Chlorambucil Versus Plus Rituximab in MALT Lymphoma) was launched to compare chlorambucil alone versus plus rituximab patients not previously given systemic anticancer therapy. Patients and Methods responding or suitable for local therapy were eligible. In arm A, daily 6 mg/m 2 orally (PO) weeks. Responding those...
Primary cutaneous B-cell lymphomas (PCBCLs) are a distinct group of primary with few and conflicting data on their prognostic factors.The study included 467 patients PCBCL who were referred, treated, observed in 11 Italian centers (the Study Group for Cutaneous Lymphomas) during 24-year period (1980 to 2003). All the reclassified according WHO-European Organisation Research Treatment Cancer (EORTC) classification.Follicle center lymphoma (FCL) accounted 56.7% occurrences, followed by...
Purpose Primary testicular lymphoma (PTL) has poor prognosis with failures in contralateral testis, CNS, and extranodal sites. To prevent these events, we designed an international phase II trial (International Extranodal Lymphoma Study Group 10 [IELSG-10]) that addressed feasibility activity of conventional chemoimmunotherapy associated CNS prophylaxis testis irradiation. The was conducted by the IELSG Italian Foundation. Patients Methods Fifty-three patients (age 22 to 79 years) untreated...
We describe 13 cases of a peculiar lymphoid tumour containing very large numbers reactive histiocytes. The tumours occurred in young patients (mean age 14.8 y) who presented with systemic symptoms and superficial lymphadenopathy. Microscopic examination revealed diffuse effacement lymph node structure due to the presence histiocytes intermingled variable number anaplastic cells. latter, some cases, were isolated, while others they arranged clusters or diffusely present residual sinuses....
Purpose There is no consensus on the optimal systemic treatment of patients with extranodal marginal zone lymphoma mucosa-associated lymphoid tissue. The IELSG-19 phase III study, to our knowledge, was first such study address question first-line in a randomized trial. Patients and Methods Eligible were initially randomly assigned (1:1 ratio) receive either chlorambucil monotherapy (6 mg/m
To assess the role of [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) after rituximab and anthracycline-containing chemoimmunotherapy in patients with primary mediastinal large B-cell lymphoma (PMLBCL).Among 125 prospectively enrolled, 115 were eligible for central review PET/CT scans at completion standard chemoimmunotherapy, by using a five-point scale. Consolidation radiotherapy (RT) was permitted given to 102 patients.Fifty-four (47%) achieved...
Axicabtagene ciloleucel showed efficacy for relapsed/refractory large B-cell lymphomas (LBCL), including primary mediastinal (PMBCL); however, only few PMBCLs were reported. Aim was to evaluate and safety of axicabtagene in patients with PMBCL compared those other LBCL, enrolled the Italian prospective observational CART-SIE study. (n = 70) younger, higher percentage bulky refractory disease, LBCLs 190). Median follow-up time infused 12.17 months (IQR 5.53,22.73). The overall (complete +...
Standardizing tumor measurement on <sup>18</sup>F-FDG PET is crucial for the routine clinical use of powerful PET-derived lymphoma prognostic factors such as metabolic volume (MTV) and total lesion glycolysis (TLG). The recent proposal an SUV 4 a new reference segmentation threshold most aggressive lymphomas may homogenize volume-based metrics facilitate their application. <b>Methods:</b> This study compared MTV TLG in primary mediastinal B-cell (PMBCL) patients estimated using current at...
PURPOSE The purpose of this study was to investigate the prognostic value time relapse in 188 adult patients with intermediate- or high-grade non-Hodgkin's lymphoma (NHL) included on Parma trial at their first relapse. PATIENTS AND METHODS median follow-up these is 102 months after registration onto study. Time calculated from initial diagnosis, and a cutoff 12 used separate 77 defined as early 111 late RESULTS Patients relapses had significantly different overall response rates salvage...
Promising new therapeutic options for follicular lymphoma (FL) include fludarabine plus mitoxantrone (FM) and the mouse/human anti-CD20 antibody, rituximab. We performed a randomized comparative trial of FM with cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) front-line chemotherapy without sequential rituximab.All previously untreated CD20(+) FL patients presenting in 15 Italian cooperative institutions from October 1999 were randomly allocated to or CHOP. Following clinical...
The authors consider the development of a knowledge base branch related to rotor electrical faults in squirrel cage machines, be implemented an expert system (ES), utilizing instantaneous values as input data. is organized two levels: first level diagnostic indexes for orientation ES inference engine toward appropriate fault tree are utilized. second includes deep with data set obtained on basis complete faulty machine model. concern how distinguish events from healthy signals due...
PURPOSE To evaluate, in a prospective multicentric study, the efficacy of conventional salvage chemotherapy (dexamethasone, cisplatin, and cytarabine [DHAP]) versus high-dose (carmustine, etoposide, cytarabine, cyclophosphamide [BEAC]) followed by autologous bone marrow transplantation (ABMT) patients with aggressive non-Hodgkin's lymphoma (NHL) clinical partial response (PR) after two thirds front-line therapy. PATIENTS AND METHODS From August 1988 to 1991, 286 NHL were randomized seven...