A5034220119- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- CNS Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Cancer Treatment and Pharmacology
- Musculoskeletal pain and rehabilitation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Sarcoma Diagnosis and Treatment
- Migraine and Headache Studies
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Renal Transplantation Outcomes and Treatments
- Diet and metabolism studies
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- Lung Cancer Research Studies
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2016-2025
Piedmont Reference Center for Epidemiology and Cancer Prevention
2016-2025
Istituto Ortopedico Rizzoli
2021-2024
Howard Hughes Medical Institute
2024
University of California, Berkeley
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Torino e-district
2023
Universitat Autònoma de Barcelona
2011-2022
University of Bologna
2018-2021
University of Turin
2012-2020
This open-label, randomized, phase 3 study compared melphalan at a dose of 200 mg per square meter body-surface area plus autologous stem-cell transplantation with melphalan-prednisone-lenalidomide (MPR) and lenalidomide maintenance therapy no in patients newly diagnosed multiple myeloma.We randomly assigned 273 65 years age or younger to high-dose MPR consolidation after induction, 251 therapy. The primary end point was progression-free survival.The median follow-up period 51.2 months. Both...
Tracheotomy is used to replace endotracheal intubation in patients requiring prolonged ventilation; however, there considerable variability the time considered optimal for performing tracheotomy. This of clinical importance because timing a key criterion tracheotomy and who receive one require large amount health care resources.To determine effectiveness early (after 6-8 days laryngeal intubation) compared with late 13-15 reducing incidence pneumonia increasing number ventilator-free...
Purpose In patients with myeloma, thalidomide significantly improves outcomes but increases the risk of thromboembolic events. this randomized, open-label, multicenter trial, we compared aspirin (ASA) or fixed low-dose warfarin (WAR) versus low molecular weight heparin (LMWH) for preventing thromboembolism in myeloma treated thalidomide-based regimens. Patients and Methods A total 667 previously untreated who received thalidomide-containing regimens had no clinical indication...
A retrospective database was developed by the European Society of Thoracic Surgeons, collecting patients submitted to surgery for thymic tumours analyse clinico-pathological prognostic predictors.A total 2151 incident cases from 35 institutions were collected 1990 2010. Clinical-pathological characteristics analysed, including age, gender, associated myasthenia gravis stage (Masaoka), World Health Organization histology, type tumour [thymoma, carcinoma (TC), neuroendocrine (NETT)], resection...
To assess efficacy and safety of noninvasive ventilation-plus-extracorporeal Co2 removal in comparison to ventilation-only prevent endotracheal intubation patients with acute hypercapnic respiratory failure at risk failing ventilation.Matched cohort study historical control.Two academic Italian ICUs.Patients treated ventilation for due exacerbation chronic obstructive pulmonary disease (May 2011 November 2013).Extracorporeal CO2 was added when (arterial pH ≤ 7.30 arterial PCO2 > 20%...
Purpose The clinical impact of positron emission tomography (PET) evaluation performed early during first-line therapy in patients with advanced-stage Hodgkin lymphoma, terms providing a rationale to shift who respond poorly onto more intensive regimen (PET response-adapted therapy), remains be confirmed. Patients and Methods phase II part the multicenter HD0801 study involved 519 de novo lymphoma received an initial treatment doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) underwent...
In recent years, the outcome of mantle cell lymphoma (MCL) has improved, especially in younger patients, receiving cytarabine-containing chemoimmunotherapy and autologous stem transplantation. Nevertheless, a proportion MCL patients still experience early failure. To identify biomarkers anticipating failure intensive chemotherapy MCL, we performed target resequencing DNA profiling purified tumor samples collected from enrolled prospective FIL-MCL0208 phase 3 trial (high-dose followed by...
Ultrasound can influence the diagnosis and impact treatment plan in critical patients. The aim of this study was to determine whether, without encountering major environment- or patient-related limitations, ultrasound examination under a care ultrasonography protocol be performed detect occult anomalies, prompt urgent changes therapy induce further testing interventions, confirm modify diagnosis.One hundred twenty-five consecutive patients admitted general intensive unit were assessed...
Currently, treatment allocation of patients with Mantle Cell Lymphoma (MCL) is mainly based on age and medical fitness. The combined MCL International Prognostic Index (MIPI-c) allows to predict prognosis using clinical factors (MIPI) the Ki-67 index. However, high p53 expression as surrogate for TP53 alterations has demonstrated be an independent predictor poor outcome. We aimed define a clear high-risk group combination MIPI, expression/TP53 alteration. A total 684 from prospective...
To prospectively evaluate (a) effectiveness and limits of dual-echo chemical-shift magnetic resonance (MR) imaging for distinguishing hyperplastic thymus from anterior mediastinal tumors in adulthood by using ratio ( CSR ) signal intensity index SII ), with proposal optimal threshold value each, (b) whether age affects these indexes.Study was institutional review board approved, informed consent obtained. Ninety-two subjects (53 men, 39 women; range, 18-84 years) were divided into a rebound...