A5042904167- Immune cells in cancer
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Chemokine receptors and signaling
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- IL-33, ST2, and ILC Pathways
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Blood disorders and treatments
- Lung Cancer Treatments and Mutations
- Eosinophilic Esophagitis
- Radiopharmaceutical Chemistry and Applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pelvic floor disorders treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Degradation and Inhibitors
- Olfactory and Sensory Function Studies
Sapienza University of Rome
2013-2025
Istituto Pasteur
2021-2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2025
University of Bologna
2023
University of Pisa
2015-2018
Policlinico Umberto I
2012-2017
Fondazione Intergruppo Italiano Linfomi Onlus
2009-2015
Mandelli (Italy)
2004
Abstract Microglia, the brain's resident macrophages, actively contribute to homeostasis of cerebral parenchyma by sensing neuronal activity and supporting synaptic remodeling plasticity. While several studies demonstrated different roles for astrocytes in sleep, contribution microglia regulation sleep/wake cycle modulation day phases has not been deeply investigated. Using light as a zeitgeber cue, we studied effects microglial depletion with colony stimulating factor‐1 receptor antagonist...
Abstract The mechanisms of communication between the brain and immune cells are still largely unclear. Here, we characterize populations resident natural killer (NK) innate lymphoid (ILC) 1 in meningeal dura layer adult mice. We describe that ILC1/NK cell-derived interferon-γ acetylcholine can contribute to modulation homeostatic functions, shaping synaptic neuronal transmission neurotransmitter levels with effects on mice behavior. In detail, plays a role formation non-spatial memory,...
Type 1 innate lymphoid cells (ILC1) are tissue-resident lymphocytes that provide early protection against bacterial and viral infections. Discrete transcriptional states of ILC1 have been identified in homeostatic pathological contexts. However, whether these delineate with different functional properties is not completely understood. Here, we show liver heterogeneous for the expression distinct effector molecules surface receptors, including granzyme A (GzmA) CD160, mice. expressing high...
Background: Lung transplantation is a life-saving option for patients with end-stage respiratory diseases, but risk of infections remains critical ensuring long-term organ function. This study aimed to assess immune recovery in lung transplant recipients by measuring IFN-γ levels using the QuantiFERON Monitor Test (QFM). Results were correlated episodes infection and rejection explore assay’s predictive potential. Methods: A retrospective was conducted on 15 at Transplant Centre Turin (Città...
The anti-metastatic activity of NK cells is well established in several cancer types, but the mechanisms underlying cell metastasis infiltration and acquisition anti-tumor characteristics remain unclear. Herein, we investigated cellular molecular factors required to facilitate generation an ILC1-like CD49a+NK population within liver (LM) environment colorectal (CRC). We show that had highest cytotoxic capacity among metastasis-infiltrating MC38 mouse model. Furthermore, chemokine receptor...
Abstract: Imatinib related non‐haematological side‐effects are reported in <10% of chronic myeloid leukaemia patients and include oedema, weight gain, nausea, vomiting muscle cramps. Cutaneous reactions well‐recognized events occurring mostly treated at doses 600 mg/d higher, either stable or progressive disease. We report on our experience relating to dermatological toxicities imatinib CML showing a spectrum skin ranging from rashes cutaneous carcinoma.
Patterns of receptors for chemotactic factors regulate the homing leukocytes to tissues. Here we report that CCRL2/chemerin/CMKLR1 axis represents a selective pathway natural killer (NK) cells lung. C-C motif chemokine receptor-like 2 (CCRL2) is nonsignaling seven-transmembrane domain receptor able control lung tumor growth. CCRL2 constitutive or conditional endothelial cell targeted ablation, deletion its ligand chemerin, were found promote progression in Kras/p53Flox cancer model. This...
Most patients with Philadelphia chromosome (Ph)-positive chronic myeloid leukemia (CML) in phase (CP) who receive treatment imatinib achieve complete cytogenetic remission (CCR), which is correlated tightly long-term progression-free survival. In these patients, the occurrence of blastic crisis (BC) rare, and its clinical biologic characteristics are not well known.Among 164 received were followed for a median 35 months, 11 (6.7%) developed BC; this was sudden (i.e., it occurred within 3...
Radioimmunotherapies with Zevalin® (RIT-Z) showed encouraging results in patients relapsed/refractory follicular lymphoma (FL), leading frequently to failure-free intervals longer than those achieved by the last previous therapy. We compared time-to-event variables obtained before and after RIT-Z relapsed FL, previously exposed rituximab. All non-transformed, non-refractory, non-rituximab-naïve FL who have been treated two different centres Europe were included. Staging response assessed...