A5062766066- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Immune cells in cancer
- Chemokine receptors and signaling
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- interferon and immune responses
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- NF-κB Signaling Pathways
- Sarcoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dermatology and Skin Diseases
- Protein Degradation and Inhibitors
- Phosphodiesterase function and regulation
- Systemic Lupus Erythematosus Research
- Angiogenesis and VEGF in Cancer
- Histiocytic Disorders and Treatments
University of Brescia
2014-2024
Brescia University
2013-2017
Arcos (United States)
2011
Sophien-und Hufeland Klinikum
2011
University of Turin
2011
Institute of Oncology Research
2006
IRCCS Istituto Auxologico Italiano
2003
University of Milan
2003
Istituti di Ricovero e Cura a Carattere Scientifico
2003
Daido University
2003
Members of the Toll-like receptor (TLR) family probably play a fundamental role in pathogen recognition and activation innate immunity. The present study used systematic approach to analyze how different human leukocyte populations express specific transcripts for first five characterized TLR members. TLR1 was expressed all leukocytes examined, including monocytes, polymorphonuclear leukocytes, T B cells, NK cells. In contrast TLR2, TLR4, TLR5 were myelomonocytic elements. Exposure bacterial...
Psoriasis is a type I interferon-driven T cell–mediated disease characterized by the recruitment of plasmacytoid dendritic cells (pDC) into skin. The molecules involved in pDC accumulation psoriasis lesions are unknown. Chemerin only inflammatory chemotactic factor that directly active on human blood vitro. aim this study was to evaluate role chemerin/ChemR23 axis Prepsoriatic skin adjacent and early were strong expression chemerin dermis presence CD15+ neutrophils CD123+/BDCA-2+/ChemR23+...
The inflammatory and IFN pathways of innate immunity play a key role in the resistance pathogenesis coronavirus disease 2019 (COVID-19). Innate sensors SARS-CoV-2-associated molecular patterns (SAMPs) remain to be completely defined. Here, we identified single-stranded RNA (ssRNA) fragments from SARS-CoV-2 genome as direct activators endosomal TLR7/8 MyD88 pathway. same sequences induced human DC activation terms phenotype function, such cytokine production Th1 polarization. A bioinformatic...
The excessive production of type I IFNs is a hallmark and main pathogenic mechanism many autoimmune diseases, including systemic lupus erythematosus (SLE). In these pathologies, the sustained secretion dependent on improper activation plasmacytoid DCs (pDCs) by self-nucleic acids. However, nature origin pDC-activating acids still incompletely characterized. Here, we report that exosomes isolated from plasma SLE patients can activate IFN-α human blood pDCs in vitro. This requires endosomal...
Abstract Toll is a Drosophila gene essential for ontogenesis and antimicrobial resistance. Several hortologues of have been identified cloned in vertebrates, namely Toll-like receptors (TLR). Human TLR are growing family molecules involved innate immunity. structurally characterized by cytoplasmic Toll/interleukin-1R (TIR) domain extracellular leucine-rich repeats. so far activate the My D88/IRAK signaling cascade, which bifurcates leads to NF-κB c-Jun/ATF2/TCF activation. Genetic, transfer,...
The homeostatic chemokine CXCL13 is preferentially produced in B-follicles and crucial the lymphoid organ development by attracting B-lymphocytes that express its selective receptor CXCR5. Follicular dendritic cells (FDCs) have been identified as main cellular source of this organs. Recently, genome-wide approaches suggested follicular CD4 T-helper (T(H)F) additional producers germinal centre neoplastic counterpart T(H)F (CD4+ tumour T-cells angioimmunoblastic T-cell lymphoma) retains...