A5006168476- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Hematological disorders and diagnostics
- Hemoglobinopathies and Related Disorders
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Bone and Joint Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- CNS Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Disorders and Syndromes
- Fungal Infections and Studies
- Viral-associated cancers and disorders
- Immunodeficiency and Autoimmune Disorders
- Glioma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Central Venous Catheters and Hemodialysis
- Polyomavirus and related diseases
- Histone Deacetylase Inhibitors Research
Università Campus Bio-Medico
2014-2023
Gruppo CLAS (Italy)
2020
Campus Bio Medico University Hospital
2014-2019
Fondazione Gimema Onlus
2015
University of Rome Tor Vergata
2006-2014
Policlinico Tor Vergata
2006-2010
St. Eugenio Hospital
2007-2008
Sapienza University of Rome
2004-2005
Mandelli (Italy)
2004
Purpose Despite the identification of several baseline prognostic indicators, outcome patients with acute myeloid leukemia (AML) is generally heterogeneous. The effects autologous (AuSCT) or allogeneic stem-cell transplantation (SCT) are still under evaluation. Minimal residual disease (MRD) states may be essential for assigning to therapy-dependent risk categories. Patients and Methods By multiparametric flow cytometry, we assessed levels MRD in 142 AML who achieved complete remission after...
Background and Objectives To date, bone marrow (BM) is the most common source of cells to use in order assess minimal residual disease (MRD) acute myeloid leukemia (AML). In present study, we investigated whether peripheral blood (PB) could be an alternative for monitoring MRD AML.Design Methods Fifty patients with AML were monitored after achievement complete remission. Using multiparametric flow cytometry compared levels 50 48 pairs BM PB induction consolidation, respectively.Results After...
Ocular Adnexal Lymphomas are the first cause of primary ocular malignancies, and among them most common MALT Lymphomas. Recently systemic immunotherapy with anti-CD20 monoclonal antibody has been investigated as first-line treatment; however, optimal management for is still unknown. The present study evaluated retrospectively outcome seven consecutive patients Lymphomas, whom six were treated single agent Rituximab. All received 6 cycles Rituximab 375 mg/mq every 3 weeks intravenously....
We explored the safety and efficacy of bortezomib given as single agent in patients with untreated or relapsed/refractory acute myeloid leukemia (AML), unfit for conventional chemotherapy. Fourteen were treated 1.5 mg/m 2 administered twice weekly two weeks, every 3 weeks. Median age was 70 years (range 60–81) median number cycles delivered 1–4). Of 13 evaluable patients, 8 (61%), administration resulted an antileukemic effect demonstrated by peripheral blood and/or bone marrow blast...
In acute lymphoblastic leukemia, flow cytometry detects more accurately leukemic cells in patients' cerebrospinal fluid compared to conventional cytology. However, the clinical significance of positivity with a negative cytology - occult central nervous system disease is not clear. framework national Campus ALL program, we retrospectively evaluated incidence and its impact on outcome 240 adult patients newly diagnosed leukemia. All samples were investigated by cytometry. The presence ≥10...
Fertility and gonadal function represent one of the most important aspects for long-term lymphoma survivors.The aim our study was to determine possible risk factors, such as age at treatment, chemotherapeutic regimen, protection with oral contraceptives (OCs), gonadotropin-releasing hormone (GnRH) analogues in female patients treated Hodgkin's (HL) or non-Hodgkin (NHL) a reproductive age.Patients between 16 50 years time HL NHL diagnosis were selected. Eligible requested respond...
We assessed by flow cytometry minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) given standard‐dose (SDAC) and high‐dose ARA‐C (HDAC) regimens. Of 163 enrolled, 130 (median age, 45 years; range, 18–59 years) qualified for analysis, all achieving complete remission after treatment SDAC ( n = 78) or HDAC 52) plus etoposide daunorubicin. Consolidation consisted of intermediate‐dose MRD negativity was significantly more frequent the vs. arm both induction (37% 15%, P...
Health-related quality of life (HRQoL) is an important goal therapy for patients with myelodysplastic syndromes (MDS); however, little known about HRQoL these at clinical presentation. We report profile newly diagnosed MDS across both the International Prognostic Scoring System (IPSS) and IPSS-Revised (IPSS-R) classifications, stratified by sex age group categories, aiming to also establish European Organization Research Treatment Cancer Quality Life Questionnaire-Core30 (EORTC QLQ-C30)...
Myelodysplastic syndrome patients are subjects of advanced age, vulnerable and frail, whose outcome is heavily influenced by pre-existing comorbidities worsening the hematologic condition. Infections a rather common cause death (around 30%), especially, but not only, for IPSS-R higher risk patients.1-3 In MDS there significant impairment lymphopoiesis, resulting in lymphopenia (ALC < 1.0 × 109/l) around 38% poor prognosis.4 Data on innate adoptive immune systems (either disease related or...
Cytomegalovirus (CMV) infection represents one of the main cause mortality after Stem Cell Transplantation. Recently, a protective effect T allele rs12979860 IL28B Single Nucleotide Polymorphisms (SNPs) against CMV in allogenic stem cell transplantation was suggested. We investigate whether SNP and relative rs368234815 (IFNλ4) genotype may affect incidence active Autologous (Auto-SCT) setting. The study included 99 patients who underwent to Auto-SCT. IL28 IFNΔ4 SNPs were correlated with...
Abstract Pulmonary infections (PIs) are a major complication of patients with myelodysplastic syndromes (MDS). We retrospectively evaluated 234 MDS treated azacytidine (AZA). The total number AZA cycles was 2886 (median 8 per patient). There were 111 episodes PI (3.8% cycles) in 81 (34.6%). PIs considered fungal origin 27 cases (24.3%), associated to bacteremia 11 (9.9%), influenza infection two (1.8%) and unknown the remaining 71 (64.0%). Forty‐five documented 1 4 (5.1% 875 66 beyond fourth...
Abstract: Paroxysmal cold haemoglobinuria (PCH) is an autoimmune haemolytic anaemia caused by the Donath–Landsteiner antibody. It classically described in association with chronic syphilis or after acute viral infections. We describe first case of PCH presented as a late manifestation advanced myelofibrosis associated antiphospholipid syndrome, that promptly responded to high dosage prednisone.