A5059892148- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- Protein Degradation and Inhibitors
- Acute Myeloid Leukemia Research
- Cancer Treatment and Pharmacology
- Bone health and treatments
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Biomarkers in Disease Prognosis
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Hematopoietic Stem Cell Transplantation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Peptidase Inhibition and Analysis
- Family and Patient Care in Intensive Care Units
- Non-Invasive Vital Sign Monitoring
- Immunotherapy and Immune Responses
- Biosimilars and Bioanalytical Methods
- Hematological disorders and diagnostics
Università Campus Bio-Medico
2015-2025
Campus Bio Medico University Hospital
2014-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Ospedale di Santo Spirito
2023
City of Hope
2020
Institute of Cell Biology and Neurobiology
2018
Background/Objectives: Treatments for multiple myeloma (MM) have expanded in the last decade, and overall survival (OS) of MM patients (pts) is continuous improvement. With availability new treatments use high-dose chemotherapy, followed by autologous hematopoietic stem cell transplantation (ASCT), median OS newly diagnosed (NDMM) pts 6–8 years. To date, approximately 50% 28% are still alive at 5 years 10 Few data reported concerning characteristics long-term pts. Methods: aim this...
Abstract Clinical use of immune-checkpoints inhibitors (anti PD-1/PD-L1) resulted very effective for the treatment relapsed/refractory classic Hodgkin Lymphoma (CHL). Recently, T cell Ig and ITIM domains (TIGIT) has been recognized as an immune checkpoint receptor able to negatively regulate functions. Herein, we investigated expression TIGIT in CHL microenvironment order find a potential new target inhibitor therapy. TIGIT, PD-1 PD-L1 was evaluated 34 consecutive patients with CHL....
Fertility and gonadal function represent one of the most important aspects for long-term lymphoma survivors.The aim our study was to determine possible risk factors, such as age at treatment, chemotherapeutic regimen, protection with oral contraceptives (OCs), gonadotropin-releasing hormone (GnRH) analogues in female patients treated Hodgkin's (HL) or non-Hodgkin (NHL) a reproductive age.Patients between 16 50 years time HL NHL diagnosis were selected. Eligible requested respond...
In solid tumors and lymphomas, the neutrophil/lymphocyte (N/L) ratio at diagnosis has been shown to be a prognostic factor. The aim of our study was validate originally reported N/L cut-point 3.5 in patients with diffuse large B-cell lymphoma (DLBCL) registered an Italian real-life database. role on event-free survival (EFS) overall (OS) assessed 505 DLBCL. Patients <3.5 (n = 249) had 4-year EFS probability 76% OS 86%, significantly higher than 4 year rate 48% 64% ≥3.5 256, both p<.0001)....
Diffuse large B-cell lymphoma (DLBCL) is an aggressive, heterogeneous neoplasm where prognostication and therapeutic decision are challenging. The available prognostic tools not able to identify all patients refractory treatment. MicroRNAs, small RNAs frequently deregulated in cancer, stably circulate biofluids, representing interesting candidates for non-invasive biomarkers. Here we validated serum miR-22, evolutionarily conserved microRNA, as a prognostic/predictive biomarker DLBCL....
Cytomegalovirus (CMV) infection represents one of the main cause mortality after Stem Cell Transplantation. Recently, a protective effect T allele rs12979860 IL28B Single Nucleotide Polymorphisms (SNPs) against CMV in allogenic stem cell transplantation was suggested. We investigate whether SNP and relative rs368234815 (IFNλ4) genotype may affect incidence active Autologous (Auto-SCT) setting. The study included 99 patients who underwent to Auto-SCT. IL28 IFNΔ4 SNPs were correlated with...
Sarcopenia has been associated with chronic diseases and cancer. The aim of this study was to evaluate sarcopenia in multiple myeloma patients undergoing autologous stem cell transplantation.
Abstract The multiple myeloma (MM) treatment has changed over the last years due to introduction of novel drugs. Despite improvements in MM outcome, remains an incurable disease. Daratumumab is a human IgGK monoclonal antibody targeting CD38 with tumor activity associated immunomodulatory mechanism. In combination standard care regimens, including bortezomib (Vd) or lenalidomide (Rd), daratumumab prolonged progression‐free survival (PFS) patients (pts) relapsed/refractory (RRMM) and new...
Tuberculous meningoencephalitis is a rare disease associated with high morbidity and mortality. We report patient hairy cell leukemia in complete remission who, after single cycle of chemotherapy cladribine, presented fever neurological deficits. Laboratory diagnosis tuberculous was made by polymerase chain reaction testing for Mycobacterium tuberculosis cerebrospinal fluid. Despite the prompt institution antitubercular-therapy, patient's general condition did not improve he died....
High-dose chemotherapy followed by autologous stem cell transplantation (auto-SCT) is the standard treatment for young patient ≤65 years with multiple myeloma (MM). The role of auto-SCT in elderly patients older than 70 remains controversial era novel agents and especially since recent introduction monoclonal antibodies (AbMo). In this study, we evaluated 12 MM over old undergoing (elderly graft cohort) seven centers GIMEMA Working Group Lazio. We compared baseline characteristics, outcome...
Neoangiogenesis has a crucial role in multiple myeloma (MM), and circulating endothelial cells (CECs) contribute to neovascularization by inducing tumor progression metastasis repairing damage bone marrow vasculature after stem cell transplantation (HSC). We recently proved national multicenter study the possibility reach high-level standardization CEC count analysis based on polychromatic flow cytometry Lyotube (BD). Our aimed at assessing kinetics of CECs patients with MM undergoing...
The assessment of cardiorespiratory fitness may be useful in different scenarios, such as to assess patients' health, athletes' and workers' status, performances. Among others, heart rate (HR) respiratory (RR) are very informative parameters. Therefore, their continuous monitoring beneficial the abovementioned scenarios. In addition, knowledge these two parameters during a physiological woman condition: pregnancy. this condition, it also monitor fetal movements since can considered an...
Objective: Multiple Myeloma (MM) is characterized by uncoupling of bone resorption from formation which leads to the predominance resorption. Bisphosphonates are chemical compounds that selectively concentrate at interface active osteoclasts and surface where they inhibit osteoclast activity. Aim this study was describe cytokines behaviour in MM evaluate whether zoledronic acid could have an vivo anti-angiogenic property as observed solid tumours.Methods: Serum samples 29 (16 males 13...