A5025046387- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Breast Implant and Reconstruction
- Breast Cancer Treatment Studies
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Viral-associated cancers and disorders
- Medical Imaging and Pathology Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Electric Motor Design and Analysis
- CNS Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Magnetic Properties and Applications
- Cutaneous lymphoproliferative disorders research
- Lung Cancer Treatments and Mutations
- Genetic and Kidney Cyst Diseases
- Reconstructive Surgery and Microvascular Techniques
- Renal cell carcinoma treatment
- Breast Lesions and Carcinomas
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Non-Destructive Testing Techniques
Sapienza University of Rome
2016-2025
CTO Andrea Alesini
2018-2024
Azienda Ospedaliera Sant'Andrea
2014-2024
The University of Texas MD Anderson Cancer Center
2015-2024
Ministero della Salute
2015-2022
Stanford University
2020
Mayo Clinic in Arizona
2020
University of Kentucky
2020
Fondazione Lombardia per l’Ambiente
2020
Roger Williams Medical Center
2019
Abstract Recent insights into the role of von-Hippel Lindau (VHL) tumor suppressor gene in hereditary and sporadic clear-cell renal cell carcinoma (ccRCC) have led to new treatments for patients with metastatic ccRCC, although virtually all eventually succumb disease. We performed an integrated, genome-wide analysis copy-number changes expression profiles 90 tumors, including both VHL disease-associated hopes identifying therapeutic targets ccRCC. identified 14 regions nonrandom change, 7...
Breast implant-associated anaplastic large-cell lymphoma (BI-ALCL) is a rare type of T-cell that arises around breast implants. The optimal management this disease has not been established. goal study to evaluate the efficacy different therapies used in patients with BI-ALCL determine an treatment approach.In study, we applied strict criteria pathologic findings, assessed used, and conducted clinical follow-up 87 BI-ALCL, including 50 previously reported literature 37 unreported. A Prentice,...
In the absence of high-quality evidence, there is a need for guidelines and multidisciplinary consensus recommendations on breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL). The purpose this expert conference was to evaluate existing evidence regarding diagnosis management BIA-ALCL caused by textured implants. This article aims provide evidence-based prevention BIA-ALCL.
In recent years, studies of cancer development and recurrence have been influenced by the stem cells (CSCs)/cancer-initiating (CICs) hypothesis. According to this, is sustained highly positioned, chemoresistant with extensive capacity self renewal, which are responsible for disease relapse after chemotherapy. Growth as three-dimensional non-adherent spheroids regarded a useful methodology enrich endowed CSC-like features. We recently reported that cell cultures derived from malignant pleural...
Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare T-cell that arises around breast implants. Most patients manifest with periprosthetic effusion, whereas subset of develops tumor mass or lymph node involvement (LNI). The aim this study to describe the pathologic features nodes from BI-ALCL and assess prognostic impact LNI. Clinical findings histopathologic were assessed in 70 BI-ALCL. LNI was defined by histologic demonstration ALCL nodes. Fourteen (20%) had LNI,...
Late breast implant seroma may be the presentation of a implant-associated anaplastic large cell lymphoma (BI-ALCL), which claims for prompt recognition. However, BI-ALCL diagnosis on fine-needle aspiration (FNA) might challenging pathologists lacking experience with peri-implant effusions. Sixty-seven late seromas collected by FNA from 50 patients were evaluated Papanicolaou smear stain and immunocytochemistry blocks. A diagnostic algorithm based cellular composition, morphology percentage...
The 2022 European Association for Haematopathology/Society Hematopathology lymphoma workshop session on cavity-based lymphomas included sixty-eight cases in seven sections. disease entities discussed include primary effusion (PEL), extracavitary and confounding (ECPEL), HHV8-negative B-lineage lymphomas-effusion based (EBV-negative, EBV-positive, plasmablastic types), diffuse large B-cell associated with chronic inflammation, fibrin-associated (FA-DLBCL), breast implant-associated anaplastic...
Expression of the autoimmune regulator gene (AIRE) and presence CD25(+)/forkhead box p3 (FoxP3)(+) T regulatory (T(reg)) cells were investigated in histologically normal adult thymi thymomas using immunohistochemistry quantitative real-time polymerase chain reaction (PCR). In thymus staining for AIRE was detected nucleus some epithelial-like located medulla; AIRE-positive extremely rare could be only areas medullary differentiation two B1 type, organoid thymomas. RNA extracted from 36 cases...
Malignant pleural effusions (MPEs) could represent an excellent source to culture a wide variety of cancer cells from different donors. In this study, we set up conditions for deriving MPEs several patients affected by the most frequent form lung cancer, namely subset non small cell cancers (NSCLC) classified as Lung Adenocarcinomas (AdenoCa) which account approximately 40% cases. AdenoCa malignant gave rise in vitro cultures both adherent and/or spheroid almost all cases analyzed. We...
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon neoplasia occurring in women with either cosmetic or reconstructive breast implants. The actual knowledge about BIA-ALCL deriving from the literature presents several limits, and it remains difficult to make inferences epidemiology, cause, pathogenesis. This reason why authors decided organize evidence-based consensus conference during Maurizio Bruno Nava (MBN 2016) Aesthetic Meeting held Milan December of...
Background: The authors report four cases of breast implant–associated anaplastic large cell lymphoma (ALCL) from a single institution and propose multidisciplinary protocol. Methods: From 2012 to 2014, ALCL were diagnosed. performed the original operation, no patients referred their practice. Cases 1, 2, 4 CD4+/CD30+/ALK− with previous textured-implant reconstruction, whereas case 3 was CD8+/CD30+/ALK− polyurethane-implant augmentation. A retrospective study all who underwent implant...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the disease 2019 (COVID-19), known to be more common in elderly, who also show symptoms and are at higher risk of hospitalization death. Here, we that expression angiotensin converting enzyme (ACE2), SARS-CoV-2 cell receptor, increases during aging mouse human lungs. ACE2 upon telomere shortening or dysfunction both cultured mammalian cells vivo mice. This increase is controlled transcriptional level, Ace2 promoter...
Abstract Met protein, the high affinity receptor for hepatocyte growth factor (HGF), was highly expressed by tumour cells of 64 well‐differentiated papillary carcinomas thyroid. The p145 mature form and p170 precursor protein were both isolated from tumours. Enhanced expression associated with a 9.5 ± 5‐fold increase in MET RNA transcript levels, suggesting increased transcription gene. In same tumours, levels transcripts hypoxia inducible factor‐1 (HIF‐1), potent stimulator met gene...
In this work the magnetic flux distribution in grain-oriented steel core transformer is investigated with finite element method. A mathematical model (Model II) obtained for reluctivity tensor. The model, optimized by means of experimental values B-H curve, predicts different directions magnetization field, not just along rolling and transverse material. results are maps, as well reactance electrodynamic forces on windings. These results, isotropic anisotropic first [1], compared ones.
Recently, diffuse-large-B-cell lymphoma (DLBCL) associated with serum IgM monoclonal component (MC) has been shown to be a very poor prognostic subset although, detailed pathological and molecular data are still lacking. In the present study, clinicopathological features survival of IgM-secreting DLBCL were analyzed compared non-secreting cases in series 151 conventional treated R-CHOP. MC was detected 19 (12.5%) out patients at disease onset. 17 these secretion likely due neoplastic clone,...
This study was aimed at evaluating the feasibility, safety, immunologic and clinical responses in patients with follicular lymphoma treated monocyte-derived dendritic cells generated presence of IFNα GM-CSF (IFN-DC) combination low doses rituximab.Firstly, we analyzed vitro vivo properties IFN-DC against lymphoma. Thus, performed a phase I trial 8 refractory relapsed based on sequential intranodal injections low-dose rituximab unloaded report clinical, results enrolled patients.Preclinical...