A5079676579- Reproductive tract infections research
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Urinary Tract Infections Management
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Orthopedic Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Gut microbiota and health
- Long-Term Effects of COVID-19
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
- Antimicrobial Peptides and Activities
- SARS-CoV-2 detection and testing
- Toxin Mechanisms and Immunotoxins
- Cervical Cancer and HPV Research
- Nosocomial Infections in ICU
- Viral gastroenteritis research and epidemiology
- Microscopic Colitis
- Insect and Pesticide Research
- Infective Endocarditis Diagnosis and Management
- Syphilis Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Mycobacterium research and diagnosis
Azienda Ospedaliera Sant'Andrea
2015-2024
Sapienza University of Rome
2014-2023
Museum of Heilongjiang Province
2021
CTO Andrea Alesini
2020
Molecular Medicine Ireland
2006
(1) Background: Health workers (HWs) are at high risk of acquiring SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infections. Therefore, health authorities further recommend screening strategies for infection in exposed or high-risk HWs. Nevertheless, to date, the best/optimal method screen HWs is still under debate, and data on prevalence scarce. The present study aims assess rate amongst a teaching hospital Central Italy diagnostic performance serology (index test) comparison...
Multidrug-resistant (MDR) organisms are emerging as some of the main healthcare problems worldwide. During COVID-19 pandemic, several Infection Prevention and Control (IPC) measures have been adopted to reduce nosocomial microorganism transmission. We performed a case–control study identify if incidence MDR bacterial infections while using pandemic-related preventive is lower than in previous years. From 2017 2020, we monitored hospital discharges over four-month period (P #) (1 March 30...
Clostridium difficile is the most common pathogen between health care-associated infections and its incidence has increased during last years. lack of enough evidence about effective hygiene interventions to prevent this disease. Due coronavirus disease 2019 (COVID‑19) pandemic, several strategies reduce microorganism spread were adopted in hospital setting. The objective study was establish whether such can care associated C infection (HA-CDI) incidence. We found that, pandemic (2020)...
Late breast implant seroma may be the presentation of a implant-associated anaplastic large cell lymphoma (BI-ALCL), which claims for prompt recognition. However, BI-ALCL diagnosis on fine-needle aspiration (FNA) might challenging pathologists lacking experience with peri-implant effusions. Sixty-seven late seromas collected by FNA from 50 patients were evaluated Papanicolaou smear stain and immunocytochemistry blocks. A diagnostic algorithm based cellular composition, morphology percentage...
A seroprevalence study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was conducted in a high-incidence area located northeastern Italy.All citizens above 10 years age resident five municipalities the Autonomous Province Trento, with highest incidence disease 2019 (COVID-19) cases, were invited to participate study. Among 6098 participants, 6075 sera and standardized questionnaire administered face-to-face collected between 5 May 15 2020 examined. Symptomatic individuals...
The Coronavirus Disease (Covid-19) pandemic is rapidly spreading across the world, representing an unparalleled challenge for health care systems. There are differences in estimated fatality rates, which cannot be explained easily. In Italy, case rate was 12.7% mid-April, while Germany remained at 1.8%. Moreover, it to noted that different areas of Italy have very lethality rates. Due complexity Covid-19 patient management, paramount importance develop a well-defined clinical workflow order...
Abstract Background Low T3 syndrome is frequent in patients admitted to intensive care units for critical illness and pneumonia. It has been reported also with COVID-19, Hodgkin disease chronic lymphocytic leukemia. We analyzed the clinical relevance of COVID-19 and, particular, those associated hematological malignancies. Methods Sixty-two consecutive patients, hospitalized during first wave SARS-CoV-2 outbreak Sant’Andrea University Hospital Rome, were subdivided 38 (Group A), showing low...
The ability of some bacterial pathogens to activate Epithelial-Mesenchymal Transition normally is a consequence the persistence local chronic inflammatory response or depends on direct interaction with host epithelial cells. In this study we monitored abilities K. pneumoniae expression genes related EMT-like processes and occurrence phenotypic changes in airway cells during early steps cell infection. We describe production intracellular reactive oxygen species increased HIF-1α mRNA exposed...
Hepatitis E virus (HEV) is the most important causative agent of acute hepatitis in developing countries. The disease usually characterized by a self-limiting, benign course. However, when particular conditions coexist (pregnancy, old age, pre-existing liver disease) it may run an unfavourable To date, 4 HEV genotypes have been described. Historically, Western world, infection was considered travel-related disease, however last 2 decades great number non-travel-related autochthonous cases...
The aim of this study was to evaluate the seroprevalence B. burgdorferi and A. phagocytophila in populations workers from 4 Italian regions, known be exposed tick bites. A total 712 serum samples collected were divided as follows: 387 obtained at risk for bites 325 individuals that not considered ticks served control group. Antibodies against found 29 (7.5%) (1.2%) reactive with HGE agent 22 (5.7%) 3 (0.9%) both 1.6% forestry confirming possibility coinfection or concurrent infection....
Lyme borreliosis is a disease caused by spirochaetes belonging to the genospecies complex Borrelia burgdorferi sensu lato (s.l.) transmitted Ixodes ticks. At present, serology remains main diagnostic tool for laboratory diagnosis of borreliosis. Recently, PCR technique has been applied B. s.l., but, until now, reliable, easy-to-perform and sensitive method not described. Here we present new PCR-based detection both s.l. DNAs in serum samples collected from patients showing symptoms. Of 265...
Summary Kodamaea ohmeri is an unusual yeast‐form fungus that has recently been identified as important aetiological agent of fungaemia, endocarditis, cellulitis, funguria and peritonitis in immunocompromised patients. We present two new isolated K. . The microorganisms were by CHROMagar Candida medium, VitekII system API ID32C. Biochemical identification the yeast isolates was confirmed sequence analysis 26S ribosomal DNA. Antifungal susceptibility testing done Sensititre YeastOne showed...
In March 2020, the World Health Organization (WHO) declared that COVID-19 outbreak recorded over previous months could be characterized as a pandemic. The first known Italian SARS-CoV-2 positive case was reported on 21 February. some countries, cases of suspected “COVID-19-like pneumonia” had been earlier than those officially accepted by health authorities. This has led many investigators to check preserved biological or environmental samples see whether virus detectable dates prior stated....
Chlamydia pneumoniae has recently been associated with the development of coronary heart diseases by sero-epidemiological studies and direct detection organism in atherosclerotic tissues. The aim our study was to employ a semi-nested PCR approach investigate presence C. both normal arteries humans obtained at autopsy. Moreover, we have evaluated role infection relation extent atherosclerosis. One hundred eighty artery specimens were collected autopsy from 60 consecutive subjects (three...