A5089674181- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Wound Healing and Treatments
- Contact Dermatitis and Allergies
- Nanoparticles: synthesis and applications
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Ocular Surface and Contact Lens
- Graphene and Nanomaterials Applications
- Immunotherapy and Immune Responses
- Advanced Drug Delivery Systems
- Bee Products Chemical Analysis
- Fullerene Chemistry and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Herpesvirus Infections and Treatments
- Silk-based biomaterials and applications
- Hair Growth and Disorders
- Pressure Ulcer Prevention and Management
- Surfactants and Colloidal Systems
- Antimicrobial Peptides and Activities
- Gold and Silver Nanoparticles Synthesis and Applications
- Lipid Membrane Structure and Behavior
Charité - Universitätsmedizin Berlin
2014-2024
Clinical Research Center for Hair and Skin Science
2014-2024
Humboldt-Universität zu Berlin
2004-2024
Freie Universität Berlin
2017-2024
In-Q-Tel
2013
Advanced Dermatology
2013
Humboldt State University
2005-2008
Kumamoto University
2007
Sojo University
2007
Keele University
2003
In this study, the skin penetration and cellular uptake of amorphous silica particles with positive negative surface charge sizes ranging from 291 ± 9 to 42 3 nm were investigated. Dynamic light scattering measurements statistical analyses transmission electron microscopy images used estimate degree particle aggregation, which was a key aspect understanding results in vitro experiments. Despite partial aggregation occurring after transfer physiological media, taken up by cells size-dependent...
Chronic non-healing wounds persist as a substantial burden for healthcare systems, influenced by factors such aging, diabetes, and obesity. In contrast to the traditionally pro-regenerative emphasis of therapies, recognition immune system integral role in wound healing has significantly grown, instigating an approach shift towards immunological processes. Thus, this review explores process, highlighting engagement system, delving into behaviors innate adaptive cells chronic scenarios....
The influence of the surface functionalization silica particles on their colloidal stability in physiological media is studied and correlated with uptake cells. 55 ± 2 nm diameter functionalized by amino acids or amino- poly(ethylene glycol) (PEG)-terminated alkoxysilanes to adjust zeta potential from highly negative positive values ethanol. A transfer into water, buffers, cell culture reduces absolute value changes stability. Particles stabilized L-arginine, L-lysine, silanes short alkyl...
The cellular uptake and dissolution of trigonal silver nanoprisms (edge length 42 ± 15 nm, thickness 8 1 nm) mostly spherical nanoparticles (diameter 70 25 in human mesenchymal stem cells (hMSC's) keratinocytes (HaCaT cells) were investigated. Both particles are stabilized by polyvinylpyrrolidone (PVP), with the prisms additionally citrate. dissolved slightly pure water but strongly isotonic saline or at pH 4, corresponding to lowest limit for during uptake. tips became rounded within...
New N-methylimidazole-functionalized gold clusters 2 catalyze, in 6∶4 methanol–water solution, the cleavage of 2,4-dinitrophenyl acetate with more than an order magnitude rate acceleration respect to acetyl-N-methylhistamine 3; comparison dodecanoyl-N-methylhistamine 4 comicellized Brij 35 reveals that is still a better catalyst comicellar system and highlights analogies differences between two systems.
The investigation of nanoparticle interactions with tissues is complex. High levels standardization, ideally testing different material types in the same biological model, and combinations sensitive imaging detection methods are required. Here, we present our studies on skin, skin cells, media. Silica, titanium dioxide silver particles were chosen as representative examples for exposure to nanomaterials, e.g., unintended environmental (silica) versus intended through application sunscreen...
Improved skin penetration of thermoresponsive nanogels into human at temperatures above the phase-transition temperature.
Current research on wound infections is primarily conducted animal models, which limits direct transferability of these studies to humans. Some limitations can be overcome by using-otherwise discarded-skin from cosmetic surgeries. Superficial wounds are induced in fresh ex vivo skin, followed intradermal injection Pseudomonas aeruginosa under the wound. Subsequently, infected skin incubated for 20 hours at 37°C and CFU/wound determined. Within hours, bacteria count increased 107 109 per...
Significance Human skin consists of distinct layers and is designed to prevent water loss keep harmful materials out, which makes transcutaneous drug delivery challenging. A model for diffusion within introduced that as the only input requires experimental concentration profiles measured at three penetration times. For specific example antiinflammatory dexamethasone, modeling shows both free-energy diffusivity are highly inhomogeneous, reveals basic mechanism epidermal barrier function: slow...
Topical treatment of wound infections is often a challenge due to limited drug availability at the site infection. delivery an attractive option for reducing systemic side effects, provided that more selective and sustained local achieved. In this study, poorly water-soluble antibiotic, ciprofloxacin, was loaded on polyvinylpyrrolidone (PVP)-based foils nanofiber mats using acetic acid as solubilizer. Drug kinetics, toxicity, antimicrobial activity were tested ex vivo model based...
Adult stem cells have been extensively investigated for tissue repair therapies. Adipose-derived (ASCs) were shown to improve wound healing by promoting re-epithelialization and vascularization as well modulating the inflammatory immune response. In this study, we used ex vivo human skin cultured in a six-well plate with trans-well inserts model superficial wounds. Standardized wounds created treated allogeneic ASCs, ASCs conditioned medium (ASC-CM), or cell culture (DMEM) supplemented fetal...
Zn-protoporphyrin (ZnPP) is a promising candidate for cancer therapy. It known to inhibit heme-oxygenase-1 (HO-1), resulting in suppressed biliverdin/bilirubin production accompanying lowered antioxidative capacity. As consequence, significant suppression of tumor growth vivo was reported. Recent findings also showed that ZnPP efficiently generated reactive singlet oxygen under illumination visible light. In the present report, we describe photosensitizing capabilities water-soluble polymer...