A5049677448- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Polysaccharides and Plant Cell Walls
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Phytochemicals and Antioxidant Activities
- Cholinesterase and Neurodegenerative Diseases
- Wound Healing and Treatments
- Essential Oils and Antimicrobial Activity
- Curcumin's Biomedical Applications
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Diet and metabolism studies
- Long-Term Effects of COVID-19
- Natural Antidiabetic Agents Studies
- COVID-19 Clinical Research Studies
- biodegradable polymer synthesis and properties
- Computational Drug Discovery Methods
- COVID-19 and Mental Health
- Pharmacological Effects of Natural Compounds
- Glycosylation and Glycoproteins Research
- Algal biology and biofuel production
- Hydrogels: synthesis, properties, applications
- Silk-based biomaterials and applications
- Graphene and Nanomaterials Applications
Institute for Biomedical Research and Innovation
2019-2025
National Research Council
2009-2025
University of Palermo
2005-2023
ORCID
2021
National Research Council
2020
Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy
2010-2019
University of Palermo
2015-2019
Instituto de Investigación Biomédica de Málaga
2018
Institute of Nanostructured Materials
2007
Instituto di Biofisica
2007
Oxidative stress and dysfunctional mitochondria are among the earliest events in AD, triggering neurodegeneration. The use of natural antioxidants could be a neuroprotective strategy for blocking cell death. Here, antioxidant action ferulic acid (FA) on different paths leading to degeneration recombinant beta-amyloid peptide (rAbeta42) treated cells was investigated. Further, improve its delivery, novel drug delivery system (DDS) used. Solid lipid nanoparticles (SLNs), empty or containing...
Alzheimer's disease (AD) is an aging-related multi-factorial disorder to which metabolic factors contribute at what has canonically been considered a centrally mediated process. Although the exact underlying mechanisms are still unknown, obesity recognized as risk factor for AD and condition of insulin resistance seems be link between two pathologies. Using mice with high fat diet (HFD) we dissected molecular shared by disorders. Brains HFD fed showed elevated levels APP Aβ40/Aβ42 together...
Non-alcoholic fatty liver disease (NAFLD) confers an increased risk of cardiovascular diseases. NAFDL is associated with atherogenic dyslipidemia, inflammation and renin-angiotensin system (RAS) imbalance, which in turn lead to atherosclerotic lesions. In the present study, impact a natural dietary supplement (NDS) containing Curcuma longa, silymarin, guggul, chlorogenic acid inulin on NAFLD atherosclerosis was evaluated, mechanism action examined. C57BL/6 mice were fed HFD for 16 weeks;...
Multifunctional bioplastics have been prepared by amorphous reassembly of cellulose, hemicelluloses (xylan), and hydrolyzed lignin. For this, the biopolymers were dissolved in a trifluoroacetic acid–trifluoroacetic anhydride mixture blended different percentages, simulating those found natural woods. Free-standing flexible films obtained after complete evaporation solvents. By varying xylan lignin contents, physical properties easily tuned. In particular, higher proportions improved...
In the recent pandemic disease, called COVID-19, role of neurologists and neurobiologists represents a chance to study key features brain infection deepen neurological manifestations COVID-19 other coronavirus infections. fact, many studies suggest damage during persistent symptoms after infection. Reverse transcription PCR test, antibody tests, Computed Tomography (CT) lung, Magnetic Resonance (MR) patient were periodically performed this case report for eight months The aim article is...
Abstract Background Mitochondrial dysfunction is a critical factor in the onset and progression of neurodegenerative diseases. Recently, mitochondrial transplantation has been advised as an innovative attractive strategy to transfer replace damaged mitochondria. Here we propose, for first time, use rat brain extracted synaptosomes, subcellular fraction isolated synaptic terminal that contains mitochondria, delivery systems. Results Synaptosome preparation was validated by presence...
To investigate the systemic signs of immune-inflammatory responses in Alzheimer's disease (AD), present study we have analyzed blood lymphocyte subsets and expression activation markers on peripheral mononuclear cells (PBMCs) from
Summary Increasing evidence indicates that Alzheimer’s disease, one of the most diffused aging pathologies, and diabetes may be related. Here, we demonstrate insulin signalling protects LAN5 cells by amyloid‐β42 (Aβ)‐induced toxicity. Aβ affects both activation receptors levels phospho‐Akt, a critical molecule in this pathway. In contrast, oxidative stress induced can antagonized active Akt that, turn, inhibits Foxo3a, pro‐apoptotic transcription factor activated reactive oxygen species...
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder, characterized by loss of memory and impairment multiple cognitive functions. Amyloid beta peptide (Aβ) the main component amyloid plaques observed in brain individuals affected AD. Oxidative stress mitochondrial dysfunction, induced Aβ, are among earliest events AD, triggering neuronal degeneration cell death. Use natural molecules with antioxidant properties could be suitable strategy for inhibiting death cascade. Here,...
Aging | doi:10.18632/aging.101004. Pasquale Picone, Silvia Vilasi, Fabio Librizzi, Marco Contardi, Domenico Nuzzo, Luca Caruana, Sara Baldassano, Antonella Amato, Flavia Mulè, Pier Luigi San Biagio, Daniela Giacomazza, Marta Di Carlo
Obesity has been associated with neurodegeneration and cognitive dysfunctions. Recent data showed that pistachio consumption is able to prevent ameliorate dyslipidemia, hepatic steatosis, systemic adipose tissue inflammation in mice fed a high-fat diet (HFD). The present study investigated the neuroprotective effects of intake HFD mice. Three groups were standard (STD), HFD, or supplemented (HFD-P) for 16 weeks. Metabolic parameters (oxidative stress, apoptosis, mitochondrial dysfunction)...