A5102994407- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Polyomavirus and related diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Family and Patient Care in Intensive Care Units
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cytomegalovirus and herpesvirus research
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Lymphoma Diagnosis and Treatment
- Periodontal Regeneration and Treatments
- Bladder and Urothelial Cancer Treatments
- Bone and Joint Diseases
- Hematological disorders and diagnostics
- Mycobacterium research and diagnosis
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Shoulder Injury and Treatment
- Organ Donation and Transplantation
Campus Bio Medico University Hospital
2007-2023
Università Campus Bio-Medico
2011-2021
Kite (United States)
2018
Institute of Cell Biology and Neurobiology
2015
Medico
2009
University of Rome Tor Vergata
2008
Sapienza University of Rome
1985-1991
University of Milan
1986
Istituto di Ematologia di Bologna
1985
Abstract Circulating endothelial cells (CEC) represent a restricted peripheral blood (PB) cell subpopulation with high potential diagnostic value in many endothelium-involving diseases. However, whereas the interest CEC studies has grown, standardization level of their detection not. Here, we undertook task to align phenotypes and counts, by standardizing novel flow cytometry approach, within network six laboratories. were identified as alive/nucleated/CD45negative/CD34bright/CD146positive...
Abstract The incidence of cytomegalovirus ( CMV ) reactivations in patients with multiple myeloma MM receiving autologous stem cell transplantation ASCT is relatively low. However, the recent increased use novel agents, such as bortezomib and/or immunomodulators, before transplant, has led to an increasing Herpesviridae family virus infections. aim study was establish post‐engraftment symptomatic , and compare this that treated agents or conventional chemotherapy transplant. a survey 80...
Intervertebral disc regeneration is quickly moving towards clinical applications. However, it still missing an ideal injectable hydrogel to support mesenchymal stem cells (MSC) delivery. Herein, a new composed of platelet rich plasma (PRP) and hyaluronic acid (HA) blended with batroxobin (BTX) as gelling agent, was designed generate clinically relevant cell carrier for regeneration. PRP/HA/BTX blend tested rheological properties. Amplitude sweep, frequency rotational measurements were...
Hemorrhagic cystitis (HC) occurring after allogeneic transplantation significantly affects quality of life and, in some cases, becomes intractable, increasing the risk death. To date, its therapy is not established. We used hemostatic agent fibrin glue (FG) to treat 35 patients with refractory post-transplantation HC. Of 322 adult undergoing an for hematological malignancy, developed grade ≥ 2 HC conventional and were treated FG, diffusely sprayed on bleeding mucosa by endoscopic applicator....
Background Surgical reconstruction of chronic wounds is often infeasible due to infection, comorbidities, or poor viability local tissues. The aim this study was describe the authors’ technique for improving regenerative and antimicrobial potential a combination modified nanofat platelet-rich plasma (PRP) in nonhealing infected wounds. Methods Fourteen patients met inclusion criteria. Fat tissue harvested from lower abdomen following infiltration solution 1,000 mL NaCl solution, 225 mg...
Abstract One‐hundred thirteen adults and children with hemophilia or other congenital bleeding disorders were vaccinated against the hepatitis B virus. Each patient was given three subcutaneous injections of vaccine at monthly intervals then a fourth booster dose 14 months after first. The highly immunogenic, since 111 113 patients (98%) produced anti‐HBs (10 mlU/ml more). After first doses dose, ten anti‐LAV/HTLV‐III‐positive hemophiliacs but had lower average titer than...
We report our results with pipobroman (PB) therapy in patients essential thrombocythemia (ET). 21 consecutive untreated were treated PB from 1975 to 1984. was given at a dose of 1 mg/kg/d until platelet count dropped below 600 X 10(9)/l. In 18 (86%) hematological remission obtained. Median duration induction phase 49 d. all cases maintenance regimen required ranging 0.2 0.5 mg/kg/d, according number. Follow-up responder ranged 6 108 months (median 17 months). Treatment well tolerated and we...
The outcomes of posterolateral multilevel spine fusion in difficult clinical settings, such as an aged multi-diseased osteoporotic patient, remain unpredictable. osteoprogenitor cells bone marrow decrease with ageing without losing their osteogeneic potential. Autologous (BMCs) from iliac crest aspirate can be concentrated the operating room and platelet-rich fibrin (PRF) obtained a peripheral blood source autologous growth factors, respectively. We present case 88 year-old patient affected...
Patients undergoing hematopoietic stem cell transplant (HSCT) are particularly exposed to the risk of developing hemorrhagic cystitis (HC), which is characterized by symptoms ranging from macroscopic hematuria renal failure. Although HC significantly affects quality life and in a few cases becomes intractable leading patient death, its therapeutic management has not been established. Fibrin glue (FG), hemostatic agent derived human plasma, largely employed different surgical settings...
We report our experience with danazol in the treatment of patients refractory immune thrombocytopenic purpura (ITP). The effects this drug were investigated 10 patients, 6 males and 4 females, aged from 40 to 85 years, (median 58 years), a platelet count below 50 X 10(9)/l. had previously been treated steroids; one them also unsuccessfully splenectomized. Danazol was administered at dosage 600 mg/day for 3 months. Before after treatment, detection antiplatelet antibodies performed. Seven One...
Sixteen patients with mild and moderate hemophilia were given Desmopressin (DDAVP) subcutaneously in the absence of any actual bleeding. The response to drug - terms factor VIII coagulant activity rise became apparent 15 min after injection, reaching maximal one hour (means 3.2 times baseline levels; SD 1.21). This was not different from that elicited using intravenous route 18 hemophiliacs comparable severity same time interval. No local or general side-effects recorded subcutaneous...
A case of disseminated intravascular coagulation (DIC) and fatal myocardial infarction in a haemophilia B patient is described. DIC occurred after 4 days therapy with unactivated prothrombin complex concentrates during the post-operative period. Therapy fresh frozen plasma, heparin antithrombin III was started without efficacy; autopsy evident.
<h2>Abstract</h2> The use of granulocyte colony-stimulating factor (G-CSF) primed bone marrow (G-BM) has been recently considered as an alternative to mobilized hematopoietic stem cells from peripheral blood (G-PB), especially in the haploidentical transplant setting. purpose this study was compare effect vivo G-CSF priming on BM and PB hematopoietic, mesenchymal (MSC), immune cells. Forty healthy donors undergoing harvest for were given subcutaneous recombinant human 7 days. samples...
Current treatment regimens for Waldenstrom macroglobulinemia (WM) are based on the use of oral alkylating agents. Recently, however, other more costly agents have been proposed WM. In current study, authors report results obtained using melphalan, cyclophosphamide, and prednisone (MCP) to treat 72 patients with WM, they compare these (and associated costs) those observed aggressive protocols.Between July 1973 April 2002, documented overexpression immunoglobulin M paraprotein in 317...