A5015757656- Hematopoietic Stem Cell Transplantation
- Renal Transplantation Outcomes and Treatments
- Genetic Neurodegenerative Diseases
- Organ Donation and Transplantation
- Neurological disorders and treatments
- Mesenchymal stem cell research
- Polyomavirus and related diseases
- Prenatal Screening and Diagnostics
- Biomedical Ethics and Regulation
- Mosquito-borne diseases and control
- Pluripotent Stem Cells Research
- Erythropoietin and Anemia Treatment
- COVID-19 Clinical Research Studies
- Neutropenia and Cancer Infections
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Organ Transplantation Techniques and Outcomes
- Malaria Research and Control
- Viral Infections and Vectors
- Organ and Tissue Transplantation Research
- Blood groups and transfusion
- Artificial Intelligence in Healthcare and Education
- Antibiotics Pharmacokinetics and Efficacy
- Cancer Genomics and Diagnostics
- Hematological disorders and diagnostics
Istituto Superiore di Sanità
2014-2025
Gruppo Italiano per il Trapianto di Midollo Osseo
2019-2025
National Institute of Health
2011-2020
Health City Institute
2019-2020
Azienda Ospedaliero-Universitaria Careggi
1992-2016
University of Florence
1992-2015
Florence (Netherlands)
1996
GlaxoSmithKline (Italy)
1992
The spread of Coronavirus Disease 2019 (COVID-19) has already reached a pandemic dimension within few weeks. Italy been one the first countries dealing with outbreak COVID-19, and severe measures have adopted to limit viral transmission. COVID-19 may several implications in organ transplant activity that physicians should be aware of. initial experience gained during shows around 10% infected patients need intensive care management overcome acute respiratory distress syndrome. Due...
SARS-CoV-2 infection is heterogeneous in clinical presentation and disease evolution. To investigate whether immune response to the virus can be influenced by genetic factors, we compared HLA AB0 frequencies organ transplant recipients waitlisted patients according presence or absence of infection.A retrospective analysis was performed on an Italian cohort composed transplanted a January 2002 March 2020 time frame. Data from this were merged with registry COVID+ subjects, evaluating status...
In Italy a national Plan for the surveillance of imported and autochthonous human vector-borne diseases (chikungunya, dengue, Zika virus disease West Nile (WNV) disease) that integrates veterinary (animals vectors) surveillance, is issued revised annually according with observed epidemiological changes. Here we describe results WNV integrated systems in from 2008 to 2015. A real time data exchange protocol place between rapidly identify occurrence animal cases define update map affected...
Since February 21 2020, when the Italian National Institute of Health (Istituto Superiore di Sanità-ISS) reported first autochthonous case infection, a dedicated surveillance system for SARS-CoV-2-positive (COVID+) cases has been created in Italy. These data were cross-referenced with those inside Information Transplant System order to assess cumulative incidence (CI) and outcome SARS-COV-2 infection solid organ transplant recipients (SOTRs) who are assumed be most at risk. We compared our...
Abstract Background Fecal microbiota transplantation (FMT) is emerging as a potential treatment modality for individuals living with inflammatory bowel disease (IBD). Despite its promise, the effectiveness of FMT treating IBD, particularly ulcerative colitis (UC), still requires thorough clinical investigation. Notwithstanding differences in methodologies, current studies demonstrate inducing remission UC patients. Therefore, standardized and robust randomized trials (RCTs) are needed to...
As in 2018, when a large West Nile virus (WNV) epidemic occurred, the 2022 vector season Italy was marked by an early onset of WNV circulation mosquitoes and birds. Human infections were limited until July, we observed rapid increase number cases. We describe epidemiology human animal surveillance for compare more consolidated data June July with same period 2018.
Between August and 28 October 2024, 199 autochthonous cases of dengue virus serotype 2 were notified in the city Fano, central Italy. We describe ongoing epidemiological microbiological investigation public health measures implemented to contain outbreak. The high transmissibility extension outbreak suggest that should be expected temperate regions during favourable seasons, highlighting need for heightened awareness among healthcare providers ensure timely detection response.
In Italy, the 2018 West Nile virus transmission season started early with a high number of cases reported. One-Health surveillance, within Italian national preparedness and response plan, detected viral circulation 9 days before symptom-onset first confirmed human case; triggering timely implementation blood transplant safety measures. This is an example how functional coordination allows health authorities to use warning triggers from surveillance systems implement preventive
<h3>Objective</h3> To assess the clinical effect of caudate-putaminal transplantation fetal striatal tissue in Huntington9s disease (HD). <h3>Methods</h3> We carried out a follow-up study on 10 HD transplanted patients and 16 not-transplanted patients. All were evaluated with Unified Rating Scale (UHDRS) whose change motor, cognitive, behavioural functional capacity total scores considered as outcome measures. Grafted also received morphological molecular neuroimaging. <h3>Results</h3>...
There is considerable interest in an autologous transplantation (AT) programme for patients with high‐risk breast cancer; however, the issue of incidence occult bone marrow (BM) micrometastasis at diagnosis, and cancer contamination peripheral blood stem cell (PBSC) collections used haematological rescue, still debated. The presence BM was evaluated bilateral biopsies obtained diagnosis 33 stage II/IIIA using: (i) a ‘nested’ reverse transcriptase‐polymerase chain reaction (RT‐PCR) assay...
We report four cases of West Nile virus (WNV) transmission following a single multiorgan donation in north-eastern Italy. The transmissions were promptly detected by local transplant centres. donor had been tested for WNV nucleic acid amplification test (NAT) prior to transplantation and was negative. There no errors the nationally implemented safety protocols.
We report on a study of protein aggregation induced different cell samples by dimethyl sulfoxide (DMSO) addition. DMSO is the most commonly used cryoprotectant because it supposed to readily diffuse across lipid bilayers, thus reducing water activity within cells; despite its large use, mechanism penetration and even main interaction features with components are far from being understood. In present work, infrared absorption spectroscopy successfully applied real time detection chemical...