A5038953796- Gut microbiota and health
- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Clinical Nutrition and Gastroenterology
- Probiotics and Fermented Foods
- Nutrition and Health in Aging
- IL-33, ST2, and ILC Pathways
- Liver Disease Diagnosis and Treatment
- Digestive system and related health
- Eosinophilic Esophagitis
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Celiac Disease Research and Management
- Gastrointestinal disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Drug Transport and Resistance Mechanisms
- Colorectal Cancer Treatments and Studies
- Mycobacterium research and diagnosis
- Genetic factors in colorectal cancer
- Pregnancy and Medication Impact
- Health Systems, Economic Evaluations, Quality of Life
Università Cattolica del Sacro Cuore
2016-2025
Agostino Gemelli University Polyclinic
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Centro Clinico Nemo
2022
Case Western Reserve University
2018
University School
2018
University Gastroenterology
2017
General Department of Preventive Medicine
2016
Catholic University of America
2013
The gastrointestinal tract is a complex and dynamic network where an intricate mutualistic symbiosis modulates the relationship between host microbiota in order to establish ensure gut homeostasis. Commensal Clostridia consist of gram-positive, rod-shaped bacteria phylum Firmicutes make up substantial part total microbiota. They start colonize intestine breastfed infants during first month life populate specific region intestinal mucosa close with cells. This position allows them participate...
The gut-liver axis plays a pivotal role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), which is third leading cause hepatocellular carcinoma (HCC) worldwide. However, link between gut microbiota and hepatocarcinogenesis remains to be clarified. aim this study was explore what features are associated with HCC patients cirrhosis NAFLD. A consecutive series NAFLD-related (group 1, 21 patients), without 2, 20 healthy controls 3, patients) studied for profile, intestinal...
Background Several randomised clinical trials (RCTs) performing faecal microbiota transplantation (FMT) for the management of inflammatory bowel disease (IBD), particularly ulcerative colitis, have recently been published, but with major variations in study design. These include differences administered dose, route and frequency delivery, type placebo evaluated endpoints. Although overall outcomes appear to be promising, they are highly dependent on both donor recipient factors. Objective To...
Malnutrition is a major complication of inflammatory bowel disease (IBD). This mini review focusing on main determinants malnutrition in IBD, the most important components malnutrition, including lean mass loss and sarcopenia, as an emerging problem. Each one these needs to be well considered correct nutritional evaluation IBD patient order build multidisciplinary approach. The then possible instrumental clinical armamentarium for evaluation.
Few data exist on differences in gut microbiota composition among principal gastrointestinal (GI) diseases. We evaluated the uncomplicated diverticular disease (DD), irritable bowel syndrome (IBS) and inflammatory diseases (IBD) patients. DD, IBS, IBD patients along with healthy controls (CT) were enrolled our Italian GI outpatient clinic. Stool samples collected. Microbiota was through a metagenomic gene-targeted approach. pathology represented continuous spectrum of where displayed one...
Significance We clarify that the normal, inherent function of IL-33 following acute, resolving colitis is protection, inducing proliferation and restitution ST2L-bearing intestinal epithelial cells (IECs). Importantly, this response occurs in otherwise healthy, immunocompetent C57BL/6J (B6) mice may be different other models possessing genetic and/or immunologic abnormalities predispose to colitis, similar patients with inflammatory bowel disease. Mechanistically, although molecular...
Alcohol use disorder (AUD) represents the most common cause of liver disease. The gut microbiota plays a critical role in progression alcohol-related damage. Aim this study was to characterize microbial composition and function AUD patients with alcohol-associated disease (AALD).This included 36 (14 cirrhosis) who were active drinkers an equal number matched controls. Stool composition, serum levels lipopolysaccharide, cytokines/chemokines functional profile assessed.AUD had decreased alpha...
Abstract Background & Aim Sarcopenia is frequent in cirrhosis and associated with unfavourable outcomes. The role of the gut‐liver‐muscle axis this setting has been poorly investigated. aim study was to identify gut microbiota, metabolic inflammatory signatures sarcopenia cirrhotic patients. Methods Fifty patients assessed for presence by quantification muscle mass strength were compared age‐ sex‐matched controls. A multiomic analysis, including microbiota composition metabolomics, serum...
The gut microbiota is a well-known prognostic factor and modulator of treatment sensitivity in patients with cancers treated immune checkpoint inhibitors. However, data on hepatocellular carcinoma (HCC) are lacking. This study aimed to evaluate the role changes produced by immunotherapy intestinal environment cirrhosis HCC. Eleven Tremelimumab and/or Durvalumab were included analysis. All participants underwent profiling, quantification fecal calprotectin, serum levels zonulin-1,...
Background Ulcerative colitis (UC) is a multifactorial chronic inflammatory bowel disease (IBD) that affects the large intestine with superficial mucosal inflammation. A dysbiotic gut microbial profile has been associated UC. Our study aimed to characterize UC bacterial, fungal, and metabolic fingerprints by omic approaches. Methods The 16S rRNA- ITS2-based metataxonomics gas chromatography–mass spectrometry/solid phase microextraction (GC–MS/SPME) metabolomic analysis were performed on...
Abstract Background Fecal microbiota transplantation (FMT) is emerging as a potential treatment modality for individuals living with inflammatory bowel disease (IBD). Despite its promise, the effectiveness of FMT treating IBD, particularly ulcerative colitis (UC), still requires thorough clinical investigation. Notwithstanding differences in methodologies, current studies demonstrate inducing remission UC patients. Therefore, standardized and robust randomized trials (RCTs) are needed to...
The cure of hepatitis C virus (HCV) infection may contribute to the reduction liver fibrosis progression and potentially influence gut-liver axis.To investigate HCV eradication with direct-acting antivirals (DAAs) on gut microbiota composition as well intestinal systemic inflammatory parameters in patients cirrhosis.Consecutive HCV-related cirrhosis receiving DAA treatment were included. composition, permeability, inflammation assessed before after 1 year. Clinical outcomes such episodes...
(1) Background: There is growing interest in the assessment of muscular mass inflammatory bowel disease (IBD) as sarcopenia associated with important outcomes. The aim study was to evaluate percentage IBD patients, characterizing methods for and clinical symptoms it. (2) Methods: Consecutive patients accessing Fondazione Policlinico Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) were enrolled. Healthy elderly or sarcopenic enrolled controls. Skeletal muscle...