A5021901674- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- Cardiac Imaging and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Aortic Thrombus and Embolism
- Cholesterol and Lipid Metabolism
- Biomarkers in Disease Mechanisms
- Agricultural and Food Sciences
- Nutrition, Genetics, and Disease
- Coronary Interventions and Diagnostics
- Public Health in Brazil
- Genetic Associations and Epidemiology
- Body Contouring and Surgery
- Pancreatitis Pathology and Treatment
- Nuclear Receptors and Signaling
- Genetic factors in colorectal cancer
- Cardiovascular Function and Risk Factors
- IL-33, ST2, and ILC Pathways
- Inflammatory Myopathies and Dermatomyositis
- Cardiovascular Disease and Adiposity
- Global Public Health Policies and Epidemiology
- Healthcare Regulation
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2016-2024
Hospital São Paulo
2014-2024
Universidade de São Paulo
2015-2024
Fleury S.A. (Brazil)
2020-2024
Hospital do Coração
2017-2023
Instituto do Coração
2017-2021
Instituto Dante Pazzanese de Cardiologia
2021
Universidad Bíblica Latinoamericana
2021
Instituto Nacional de Cardiologia
2021
Hospital Israelita Albert Einstein
2016-2017
Introducao A doenca cardiovascular (DCV) e a principal causa de morte no Brasil mundo, determinando aumento da morbidade incapacidade ajustadas pelos anos vida. Embora as taxas mortalidade disability-adjusted life year (DALY) padronizadas por idade estejam diminuindo Brasil, possivelmente como resultado politicas saude bem-sucedidas, o numero total destas esta aumentando principalmente devido ao envelhecimento adoecimento populacao. presenca dos fatores risco classicos (hipertensao,...
Obesity, long considered a condition characterized by the deposition of inert fat, is now recognized as chronic and systemic inflammatory disease, where adipose tissue plays crucial endocrine role through production numerous bioactive molecules, collectively known adipokines. These molecules regulate carbohydrate lipid metabolism, immune function blood coagulability, may serve markers cardiometabolic risk. Local loops operate in consequence nutrient overload, crosstalk among its cellular...
Macrophages participate pivotally in the pathogenesis of many chronic inflammatory diseases including atherosclerosis. Adiponectin, a vasculoprotective molecule with insulin-sensitizing and anti-atherogenic properties, suppresses pro-inflammatory gene expression macrophages by mechanisms that remain incompletely understood. This study investigated effects adiponectin on major signaling pathways human macrophages. We demonstrate pretreatment these cells inhibits phosphorylation nuclear factor...
ALP -fosfatase alcalinaALT -alanina aminotransferase AMPK -proteína adenosina
Objective— To examine whether a lack of prostaglandin E receptor 4 (EP4) on bone marrow–derived cells would increase local inflammation and enhance the formation abdominal aortic aneurysm (AAA) in vivo. Methods Results— Prostaglandin 2 (PGE ) through activation EP4, can mute inflammation. Hypercholesterolemic low-density lipoprotein knockout (LDLR −/− mice transplanted with either EP4 +/+ (EP4 /LDLR or marrow received infusions angiotensin II to induce AAA. Deficiency increased incidence...
A aterosclerose é a base fisiopatológica de muitas doenças cardiovasculares, incluindo doença arterial coronariana. Trata-se uma condição inflamatória multissistêmica complexa que afeta principalmente camada íntima das artérias. Fatores risco como hipertensão, tabagismo e diabetes desencadeiam alterações funcionais no endotélio, estimulando expressão moléculas adesão, o VCAM-1, promovem migração monócitos para espaço subintimal pela ação quimiotáticas, MCP-1. Lá, os se diferenciam em...
Abstract Rare diseases comprise a diverse group of conditions, most which involve genetic causes. We describe the variable spectrum findings and clinical impacts exome sequencing (ES) in cohort 500 patients with rare diseases. In total, 164 primary were reported 158 patients, representing an overall diagnostic yield 31.6%. Most (61.6%) corresponded to autosomal dominant followed by recessive (25.6%) X‐linked (12.8%) conditions. These harbored 195 variants, among 43.6% are novel literature....
Obesity associates with increased numbers of inflammatory cells in adipose tissue (AT), including T cells, but the mechanism T-cell recruitment remains unknown. This study tested hypothesis that chemokine (C-X-C motif) receptor 3 (CXCR3) participates accumulation AT obese mice and thus regulation local inflammation systemic metabolism.Obese wild-type exhibited higher mRNA expression CXCR3 periepididymal AT-derived stromal vascular compared lean mice. We evaluated function vivo using...
Sitosterolemia is a rare autosomal recessive disorder caused by homozygous or compound heterozygous variants in ABCG5/ABCG8. The disease characterized increased plasma plant sterols. Small case series suggest that patients with sitosterolemia have wide phenotypic heterogeneity great variability on either cholesterol levels development of atherosclerotic cardiovascular disease. present study aims to characterize the prevalence and clinical features participating familial hypercholesterolemia...
Introdução A hipercolesterolemia familiar (HF) é uma causa genética comum de doença coronariana prematura, especialmente infarto do miocárdio, devido à exposição ao longo da vida a concentrações elevadas colesterol lipoproteína baixa densidade (LDL-c). Caracteriza-se por ser forma grave dislipidemia base genética, em que aproximadamente 85% dos homens e 50% das mulheres podem ter um evento coronariano antes completar os 65 anos idade, se não tratados adequadamente. HF considerada [...]