A5069948023- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Blood Coagulation and Thrombosis Mechanisms
- Genomic variations and chromosomal abnormalities
- Maternal and fetal healthcare
- Genomics and Rare Diseases
- SARS-CoV-2 detection and testing
- Venous Thromboembolism Diagnosis and Management
- Genetic factors in colorectal cancer
- Blood disorders and treatments
- Biosensors and Analytical Detection
- Obstructive Sleep Apnea Research
- Radiomics and Machine Learning in Medical Imaging
- Blood properties and coagulation
- AI in cancer detection
- Ubiquitin and proteasome pathways
- Vaccine Coverage and Hesitancy
- Inflammatory Biomarkers in Disease Prognosis
- Reproductive Health and Contraception
- Erythrocyte Function and Pathophysiology
- Dermatological and COVID-19 studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Oral and gingival health research
- Viral Infections and Outbreaks Research
Fleury S.A. (Brazil)
2019-2024
Evidence (Italy)
2021
Universidade de São Paulo
2001-2011
Universidade de Ribeirão Preto
2001-2008
Clinics Hospital of Ribeirão Preto
2007
Abstract Objective To determine whether tocilizumab improves clinical outcomes for patients with severe or critical coronavirus disease 2019 (covid-19). Design Randomised, open label trial. Setting Nine hospitals in Brazil, 8 May to 17 July 2020. Participants Adults confirmed covid-19 who were receiving supplemental oxygen mechanical ventilation and had abnormal levels of at least two serum biomarkers (C reactive protein, D dimer, lactate dehydrogenase, ferritin). The data monitoring...
Abstract The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is pressing public health systems around the world, and large population testing a key step to control this pandemic disease. Here, we develop high-throughput targeted proteomics assay detect SARS-CoV-2 nucleoprotein peptides directly from nasopharyngeal oropharyngeal swabs. A modified magnetic particle-based approach implemented on robotic liquid handler enables fully automated preparation 96 samples...
Abstract Optimizing early breast cancer (BC) detection requires effective risk assessment tools. This retrospective study from Brazil showcases the efficacy of machine learning in discerning complex patterns within routine blood tests, presenting a globally accessible and cost-effective approach for evaluation. We analyzed complete count (CBC) tests 396,848 women aged 40–70, who underwent imaging or biopsies six months after their CBC test. Of these, 2861 (0.72%) were identified as cases:...
Abstract Rare diseases comprise a diverse group of conditions, most which involve genetic causes. We describe the variable spectrum findings and clinical impacts exome sequencing (ES) in cohort 500 patients with rare diseases. In total, 164 primary were reported 158 patients, representing an overall diagnostic yield 31.6%. Most (61.6%) corresponded to autosomal dominant followed by recessive (25.6%) X‐linked (12.8%) conditions. These harbored 195 variants, among 43.6% are novel literature....
BACKGROUNDThe role of progestogens in haemostasis is controversial. Our objective to evaluate the haemostatic effects an etonogestrel-releasing implant.
Abstract A population-based household survey was performed to estimate the prevalence of IgM and IgG SARS-CoV-2 in residents six districts São Paulo City, Brazil. Serum samples collected from 299 randomly-selected adults 218 cohabitants (N=517) were tested by chemiluminescence immunoassay ten weeks after first reported case. Weighted overall seroprevalence 4.7% (95% CI 3.0-6.6%). The low suggests that most this population could still be infected. Serial serosurveys initiated aiming monitor...
Abstract Background The Complete Blood Count (CBC) is a commonly used low-cost test that measures white blood cells, red and platelets in person’s blood. It useful tool to support medical decisions, as intrinsic variations of each analyte bring relevant insights regarding potential diseases. In this study, we aimed at developing machine learning models for COVID-19 diagnosis through CBCs, unlocking the predictive power non-linear relationships between multiple analytes. Methods We collected...
Several Mendelian disorders follow an autosomal recessive inheritance pattern. Epidemiological information on many inherited may be useful to guide health policies for rare diseases, but it is often inadequate, particularly in developing countries. We aimed calculate the carrier frequencies of diseases a cohort Brazilian patients using whole exome sequencing (WES). reviewed molecular findings WES from 320 symptomatic who had status diseases. Using Hardy-Weinberg equation, we estimated...
Next-generation sequencing (NGS) has altered clinical genetic testing by widening the access to molecular diagnosis of genetically determined rare diseases. However, physicians may face difficulties selecting best diagnostic approach. Our goal is estimate rate possible diagnoses missed different targeted gene panels using data from a cohort patients with diseases diagnosed exome (ES). For this purpose, we simulated comparison between and ES: list genes harboring clinically relevant variants...
Background Sequential population-based household serosurveys of SARS-CoV-2 covering the COVID-19 pre- and post-vaccination periods are scarce in Brazil. This study investigated seropositivity trends municipality São Paulo. Methods We conducted seven cross-sectional surveys adult population-representative samples between June 2020 April 2022. The design included probabilistic sampling, test for antibodies using Roche Elecsys anti-nucleocapsid assay, statistical adjustments population...
Pro-inflammatory markers play a significant role in the disease severity of patients with COVID-19. Thus, anti-inflammatory therapies are attractive agents for potentially combating uncontrolled inflammatory cascade these patients. We designed trial testing tocilizumab versus standard care intending to improve outcomes by inhibiting interleukin-6, an important mediator
São Paulo city has been one of the regions most affected by COVID-19 pandemic in Brazil. Frequent asymptomatic and oligosymptomatic infections poor access to diagnostic tests make serosurveys crucial monitor magnitude epidemic inform public health policies, such as vaccination plans. To estimate, early epidemic, seroprevalence antibodies SARS-CoV-2 adults living six districts city, assess potential associated risk factors. This was a cross-sectional population-based survey 1,152 households...
Data-independent acquisition (DIA) allows comprehensive proteome coverage, while it also potentially works as a unified protocol to determine multitude of proteins found in blood. Because its high specificity, mass spectrometry may greatly reduce the interference observed other assays evaluate blood markers. Here, we combined DIA with volumetric absorptive microsampling (VAMS) and automated proteomics sample processing platform assess clinical As proof concept, evaluated two...
No presente artigo, revisamos diversos aspectos da etiologia, fisiopatologia, diagnóstico e tratamento coagulação intravascular disseminada (CIVD).
Background: An effective breast cancer (BC) risk-assessment tool could optimize early detection for women at higher risk while minimizing overtreatment. Liquid biopsies hold promise but are costly. We hypothesize that machine learning (ML) models can find complex BC patterns in routine blood tests, which more accessible and affordable worldwide, emerging as a promising assessment tool.Methods: In this Brazilian retrospective study, we included tests (complete counts, lipid profile, glucose)...
e13148 Background: Tumor mutation profiling has become a key component for orienteering the treatment of oncologic patients. A crucial step this is correct identification and classification pathogenic actionable variants. In present work we aimed at development validation tumor panel, based on NGS, which uses artificial intelligence variant annotation. Methods: We designed hybrid capture containing 366 genes to evaluate somatic SNVs, INDELs CNVs, calculate TMB, using customized...