A5001031174- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Disease Prevention
- Chemotherapy-induced cardiotoxicity and mitigation
- Viral Infections and Immunology Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Diabetes Treatment and Management
- Acute Myocardial Infarction Research
- Parathyroid Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Cardiac Arrhythmias and Treatments
- Lipoproteins and Cardiovascular Health
- Lanthanide and Transition Metal Complexes
- Metabolism, Diabetes, and Cancer
- Heart Failure Treatment and Management
Universidade Estadual de Campinas (UNICAMP)
2016-2025
Hospital de Clínicas da Unicamp
2016-2025
Brigham and Women's Hospital
2009-2022
Massachusetts General Hospital
2012-2021
Toronto General Hospital
2021
Sociedade Brasileira de Cardiologia
2021
Harvard University
2009-2018
Universidade Federal da Bahia
2016
Semmelweis University
2015
Hospital de Base
2015
Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy and proposed substrate for arrhythmias heart failure. In animal models, profibrotic genetic pathways are activated early, before remodeling. Data showing early responses to sarcomere-gene mutations in patients with lacking.We used echocardiography, cardiac magnetic resonance imaging (MRI), serum biomarkers collagen metabolism, hemodynamic stress, myocardial injury evaluate subjects confirmed genotype.The study involved 38...
Introducao A doenca cardiovascular (DCV) e a principal causa de morte no Brasil mundo, determinando aumento da morbidade incapacidade ajustadas pelos anos vida. Embora as taxas mortalidade disability-adjusted life year (DALY) padronizadas por idade estejam diminuindo Brasil, possivelmente como resultado politicas saude bem-sucedidas, o numero total destas esta aumentando principalmente devido ao envelhecimento adoecimento populacao. presenca dos fatores risco classicos (hipertensao,...
Abstract Aims Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). Sparse data exist on the use cardiovascular magnetic resonance (CMR) in ICI-associated myocarditis. In this study, CMR characteristics and association between features events among patients with myocarditis are presented. Methods results From an international registry myocarditis, clinical, CMR, histopathological findings were collected. Major adverse (MACE) composite death, cardiogenic...
Cardiomyocyte hypertrophy is a critical precursor to the development of heart failure. Methods phenotype cellular noninvasively are limited. The goal was validate cardiac magnetic resonance-based approach for combined assessment extracellular matrix expansion and cardiomyocyte hypertrophy.
Anthracyclines are cardiotoxic; however, there limited data characterizing the serial changes in cardiac structure and function after anthracyclines. The aim of this study was to use magnetic resonance characterize anthracycline-induced cardiotoxicity mice.This a longitudinal histological 45 wild-type male mice randomized doxorubicin (n=30, 5 mg/kg doxorubicin/week for weeks) or placebo (n=15). A performed at baseline 5, 10, 20 weeks randomization. Measures primary interest included left...
1. Introdução Nos últimos anos, foram consolidados avanços expressivos no conhecimento de amiloidose cardíaca (AC), trazendo uma profunda reformulação do seu significado clínico. Além haver evidências convincentes que AC seja causa relativamente comum insuficiência com fração ejeção preservada (ICFEP), assistimos o surgimento terapias específicas modificadoras curso natural da doença, capazes prolongar a sobrevida dos pacientes acometidos. Em paralelo, relevantes progressos nas técnicas...
The myocardial extracellular volume fraction (MECVF) has been used to detect diffuse fibrosis. Estimation of MECVF relies on quantification the T1 relaxation time after contrast enhancement, which can be sensitive equilibrium transcytolemmal water-exchange. We hypothesized that MECVF, quantified with a parsimonious 2-space water-exchange model, correlates positively connective tissue in rodent model hypertensive heart disease, whereas widely analysis based assuming fast could result...
Background Myocarditis is a highly morbid complication of immune checkpoint inhibitor (ICI) use that remains inadequately characterized. The QRS duration and the QTc interval are standardized electrocardiographic measures prolonged in other cardiac conditions; however, there no data on their utility ICI myocarditis. Methods From an international registry, ECG parameters were compared between 140 myocarditis cases 179 controls across multiple time points (pre-ICI, prior to myocarditis, at...
Introdução A última Diretriz de Insuficiência Cardíaca do Departamento da Sociedade Brasileira Cardiologia (DEIC/SBC) foi finalizada em março 2018. partir então, houve um importante número intervenções terapêuticas e abordagens diagnósticas que surgiram ou se consolidaram na prática clínica internacional pesquisa clínica. Ao lado disso, a pandemia COVID-19 trouxe-nos conhecimento sobre o modelo fisiopatológico agressão miocárdica muitas dúvidas acerca continuidade segurança dos medicamentos...
A recent large-scale clinical trial found that an initial invasive strategy does not improve cardiac outcomes beyond optimized medical therapy in patients with stable coronary artery disease. Novel methods to stratify at-risk may refine therapeutic decisions outcomes.In a cohort of 815 consecutive referred for evaluation myocardial ischemia, we determined the net reclassification improvement risk death or nonfatal infarction (major adverse events) incremental models, using guideline-based...
Childhood obesity is a significant risk factor for cardiovascular disease in adulthood. Although ventricular remodeling has been reported obese youth, early tissue-level markers within the myocardium that precede organ-level alterations have not described.We studied 21 adolescents (mean age, 17.7±2.6 years; mean body mass index [BMI], 41.9±9.5 kg/m(2), including 11 patients with type 2 diabetes [T2D]) and 12 healthy volunteers (age, 15.1±4.5 BMI, 20.1±3.5 kg/m(2)) using biomarkers of...