A5083712209- Cardiomyopathy and Myosin Studies
- Trypanosoma species research and implications
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Pulmonary Hypertension Research and Treatments
- Viral Infections and Immunology Research
- Cardiac Structural Anomalies and Repair
- Chemotherapy-induced cardiotoxicity and mitigation
- Pericarditis and Cardiac Tamponade
- Ultrasound and Hyperthermia Applications
- Cardiac Arrest and Resuscitation
- Cardiac tumors and thrombi
- Eosinophilic Disorders and Syndromes
- Simulation-Based Education in Healthcare
- Cardiac pacing and defibrillation studies
- Nuclear Structure and Function
- Myasthenia Gravis and Thymoma
- Ultrasound in Clinical Applications
- Cardiac Arrhythmias and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular and Diving-Related Complications
- Coronary Interventions and Diagnostics
- Heart Rate Variability and Autonomic Control
Universidade de São Paulo
2015-2024
Universidade Brasil
2006-2024
Universidade de Ribeirão Preto
2013-2023
Clinics Hospital of Ribeirão Preto
2007-2022
Sociedade Brasileira de Cardiologia
2021
Duke Medical Center
2017
Johns Hopkins University
2017
Duke University
2017
Hospital Italiano de Buenos Aires
2010
National Council for Scientific and Technological Development
2008
1. Introdução Nos últimos anos, foram consolidados avanços expressivos no conhecimento de amiloidose cardíaca (AC), trazendo uma profunda reformulação do seu significado clínico. Além haver evidências convincentes que AC seja causa relativamente comum insuficiência com fração ejeção preservada (ICFEP), assistimos o surgimento terapias específicas modificadoras curso natural da doença, capazes prolongar a sobrevida dos pacientes acometidos. Em paralelo, relevantes progressos nas técnicas...
Lista de Siglas/Abreviaturas 18 F-FDG – fluordesoxiglicose marcado com flúor-18 123 I-MIBG meta-iodo-benzil-guanidina iodo-123 […] Diretriz da SBC sobre Diagnóstico e Tratamento Pacientes Cardiomiopatia Doença Chagas 2023
Background Although right atrial (RA) enlargement is an established marker for adverse outcomes, the prognostic importance of RA dysfunction independent size in pulmonary arterial hypertension not known. Methods and Results Study subjects with were prospectively enrolled from 2010 to 2014. function was measured using speckle-tracking longitudinal strain rate (SR) during each phase cardiac cycle: (1) reservoir (peak strain, peak systolic SR), (2) conduit early diastolic (3) active contraction...
Chronic Chagas disease cardiomyopathy (CCC) is a result of low-intensity, but incessant, focal fibrosing myocarditis, caused by persistent T. cruzi infection associated with inflammation, mediated adverse immune mechanisms. About 30 percent infected individuals have developed throughout life the chronic cardiac form Chagas' protean clinical manifestations, such as sudden death, signs and symptoms heart failure, cardioembolic events, arrhythmia angioid symptoms. Sudden death progression...
Recent data from our laboratory have shown that patients with the indeterminate form of Chagas' disease can impairment left ventricular contractility, as evaluated by slope ventricle end-systolic pressure-dimension relationship. We also showed minimal baseline wall motion abnormalities detected two-dimensional echocardiography more intense contractility when compared to without this abnormality. The prognostic implications these findings not been established. 59 (37-76 years, mean = 55...
The purpose of these Guidelines is to inform.They do not substitute the clinical judgment doctors who, in final analysis, must determine which tests and treatments are appropriate for their patients.
The critical importance of dystrophin to cardiomyocyte contraction and sarcolemmal myofibers integrity, led us test the hypothesis that reduction/loss could be involved in pathogenesis doxorubicin-induced cardiomyopathy, order determine a possible specific structural culprit behind heart failure. Rats received total cumulative doses doxorubicin during 2 weeks: 3.75, 7.5, 15 mg/kg. Controls rats saline. Fourteen days after last injection, hearts were collected for light electron microscopy,...
1. Introdução O conhecimento médico científico sobre a cardiomiopatia hipertrófica (CMH) recebeu grande avanço nas últimas décadas. melhor entendimento da sua patogênese, os avanços expressivos no emprego dos métodos de imagem e aplicação mais corriqueira análise genética, além caracterização história natural dessa doença miocárdica, trouxeram uma profunda reformulação do seu significado clínico prognóstico. Por outro lado, esses progressos foram acompanhados desenvolvimento novas drogas...
Background Chronic Chagas cardiomyopathy in humans is characterized by segmental left ventricular wall motion abnormalities ( WMA ), mainly the early stages of disease. This study aimed at investigating detection and its correlation with underlying histopathological changes a chronic model hamsters. Methods Results Female Syrian hamsters (n=34) infected 3.5×10 4 or 10 5 blood trypomastigote Trypanosoma cruzi (Y strain) forms an uninfected control group (n=7) were investigated. After 6 months...
Right ventricular (RV) impairment is postulated to be responsible for prominent systemic congestion in Chagas disease. However, occurrence of primary RV dysfunction disease remains controversial. We aimed study systolic function patients with using cardiac magnetic resonance.This cross-sectional included 158 individuals chronic who underwent resonance. was defined as reduced ejection fraction based on predefined cutoffs accounting age and sex. Multivariable logistic regression used verify...
Altered myocardial perfusion is a common finding in chronic Chagas cardiomyopathy (CCC), but its underlying histologic changes have not been elucidated. We investigated the occurrence of defects (MPDs) and correlated regional to histology an experimental model CCC hamsters. <b>Methods:</b> Female Syrian hamsters (<i>n</i> = 34) were infected with 3.5 × 10<sup>4</sup> 10<sup>5</sup> trypomastigote forms <i>Trypanosoma cruzi,</i> Y strain, 6–10 mo afterward underwent vivo imaging including...
Summary The mechanism of isoproterenol‐induced myocardial damage is unknown, but a mismatch oxygen supply vs. demand following coronary hypotension and hyperactivity the best explanation for complex morphological alterations observed. Severe in structural integrity sarcolemma cardiomyocytes have been demonstrated to be caused by isoproterenol. Taking into account that sarcolemmal stabilized dystrophin‐glycoprotein (DGC) connects actin laminin contractile machinery extracellular matrix...
Determination of left ventricular ejection fraction (LVEF) using in vivo imaging is the cardiac functional parameter most frequently employed preclinical research. However, there considerable conflict regarding effects anesthetic agents on LVEF. This study aimed at assessing various LVEF hamsters transthoracic echocardiography. Twelve female were submitted to echocardiography separated by 1-week intervals under following conditions: 1) conscious animals, 2) animals anesthetized with...
Heart Rate Variability (HRV) and arterial pressure (AP) variability their responses to head-up tilt test (HUTT) were investigated in Post-COVID-19 syndrome (PCS) patients reporting tachycardia and/or postural hypotension. Besides tachycardia, PCS also showed attenuation of the following HRV parameters: RMSSD [square root mean sum squares differences between adjacent normal-to-normal (NN) intervals] from statistical measures; power RR (beat-to-beat interval) spectra at HF (high frequency)...
Although the possible relationship between panic disorder and mitral valve prolapse (MVP) attracted considerable research interest in 1980s 1990s, reported prevalence of MVP these patients has been inconsistent widely variable. Clinical epidemiologic studies have produced controversial data on association or definite causal 2 entities. The primary objective present review was to summarize current state knowledge MVP, including influence diagnostic criteria for results.We searched MEDLINE,...
Summary We investigated whether there is an association between anxiety disorders and mitral valve prolapse. compared prolapse prevalence in individuals with panic disorder ( n = 41), social 89) healthy controls 102) attempt to overcome the biases of previous studies. Our results show no associations or prolapse, regardless diagnostic criteria employed, that relationship these conditions seems not be clinically relevant.
Abstract Activated matrix metalloproteinases ( MMP s) cause cardiomyocyte injury during acute pulmonary thromboembolism APT ). However, the functional consequences of this alteration are not known. We examined whether doxycycline (a inhibitor) improves right ventricle function and cardiac responses to dobutamine . was induced with autologous blood clots (350 mg/kg) in anaesthetized male lambs pre‐treated (Doxy, 10 mg/kg/day, intravenously) or saline. Non‐embolized control received...