A5055891712- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Insect symbiosis and bacterial influences
- Synthesis and Biological Evaluation
- Biochemical and Molecular Research
- Lysosomal Storage Disorders Research
- Coenzyme Q10 studies and effects
- Cardiomyopathy and Myosin Studies
- Gastrointestinal motility and disorders
- Child Nutrition and Feeding Issues
- Helminth infection and control
- Parasitic Infections and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Immunology Research
- Toxin Mechanisms and Immunotoxins
- T-cell and Retrovirus Studies
- Science and Education Research
- Global Public Health Policies and Epidemiology
- Galectins and Cancer Biology
- Toxoplasma gondii Research Studies
- Cardiovascular Issues in Pregnancy
- Glycosylation and Glycoproteins Research
- Gastroesophageal reflux and treatments
- Immune Cell Function and Interaction
Universidade Federal de Goiás
2015-2025
Universidade Federal da Bahia
2023
Universidade Federal do Rio de Janeiro
2023
Justus-Liebig-Universität Gießen
2010
Universitat de Barcelona
2010
Fundação Oswaldo Cruz
2003
Simón Bolívar University
2003
Universidade de São Paulo
2003
Consejo Nacional de Investigaciones Científicas y Técnicas
2003
Universidade Federal de São Paulo
2003
Background A century after its discovery, Chagas disease still represents a major neglected tropical threat. Accurate diagnostics tools as well surrogate markers of parasitological response to treatment are research priorities in the field. The purpose this study was evaluate performance PCR methods detection Trypanosoma cruzi DNA by an external quality evaluation. Methodology/Findings An international collaborative launched expert laboratories from 16 countries. Currently used strategies...
Chagas disease is a neglected chronic condition with high burden of morbidity and mortality. It has considerable psychological, social, economic impacts. The represents significant public health issue in Brazil, different regional patterns. This document presents the evidence that resulted Brazilian Consensus on Disease. objective was to review standardize strategies for diagnosis, treatment, prevention, control country, based available scientific evidence. consensus articulation strategic...
Chagas disease is a neglected chronic condition that presents high morbidity and mortality burden, with considerable psychological, social, economic impact.The represents significant public health issue in Brazil, different regional patterns.This document the evidence resulted Brazilian Consensus on Disease.The objective was to review standardize strategies for diagnosis, treatment, prevention, control of country, based available scientific evidence.The consensus collaboration contribution...
In the acute phase and in chronic forms of Chagas disease, etiological diagnosis may be performed by detection parasite using direct or indirect parasitological methods presence antibodies serum way serological tests. Several techniques are easily available, ranging from simplest wet smear preparation to immuno-enzymatic assays with recombinant antigens that will meet most diagnostic needs. Other tests under evaluation include a molecular test polymerase chain reaction, which has shown...
This opinion piece presents an approach to standardisation of important aspect Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale strain selection representing T. diversity provide recommendations on preferred parasite stage discovery, discrete typing units include panel number strains/clones primary screens lead compounds. also consider experimental approaches assays. The Figure illustrates current...
In 2005, the World Health Organization (WHO) recognized Chagas disease (CD; Trypanosoma cruzi infection) as a neglected tropical (NTD) [1] and included it into global plan to combat NTDs [2]. The Target 3.3 of United Nations Sustainable Development Goals (UN/SDG) aims at ending epidemics by 2030 [3]. Mother-to-child (congenital/connatal) transmission is currently main mode T. over blood transfusions organ transplantations in vector-free areas within outside Latin America (LA). Based on...
Lista de Siglas/Abreviaturas 18 F-FDG – fluordesoxiglicose marcado com flúor-18 123 I-MIBG meta-iodo-benzil-guanidina iodo-123 […] Diretriz da SBC sobre Diagnóstico e Tratamento Pacientes Cardiomiopatia Doença Chagas 2023
In pokeweed (Pa-1)-stimulated human lymphocyte cultures, T cells are essential for the survival, proliferation, plasma-cell development, and high-rate Ig secretion of B cells. Their effects T-cell-specific in sense that B-cell stimulation does not take place absence even when fibroblasts or monocytes provided. The experimental system is most effective model activation lymphocytes so far described. Plasmablast development requires approximately 7 days culture. + cultures established at 1 X...
Background Migration of Latin Americans to the USA, Canada and Europe has modified Chagas disease distribution, but data on imported cases risks local transmission remain scarce. We assessed prevalence risk factors for disease, staged evaluated attitudes towards blood transfusion organ transplant among American migrants in Geneva, Switzerland. Methodology/Principal Findings This cross-sectional study included all consecutive seeking medical care at a primary facility or attending two Latino...
Chagas disease is one of the main public health issues in Latin America. Increasingly during past few decades, Trypanosoma cruzi infection has been detected North America, Europe, and Western Pacific, mainly as a result population movement. The limited availability rapid serological diagnostic tests hinders diagnosis early treatment areas endemicity nonendemicity. In collaboration with 11 national reference laboratories (NRLs) from different geographical areas, we evaluated performances...
Blood transfusion is one of the most important transmission routes Chagas' disease, a major parasitic infection in Latin America. Therefore, screening for antibodies to Trypanosoma cruzi mandatory blood banks South Most commercial serologic tests employ epimastigote antigens and show high number inconclusive false-positive results, with economic social costs.An ELISA using mixture three T. recombinant antigens, B13, 1F8, H49 (mix-ELISA), was evaluated, first panel well-characterized sera...
ABSTRACT In this study we compared the performance of Chagas Stat-Pak rapid immunochromatographic test with a standard enzyme-linked immunosorbent assay (ELISA) in serodiagnosis Chagas' disease Central America. Out 3,400 blood donor samples, 156 (4.6%) were positive both assays. Three sera out 2,084 samples from reference laboratories negative but ELISA (99.8% agreement). Agreement 100% between two tests was observed 339 additional patients cardiopathies and 175 potential donors emergency...
The clinical characteristics of acute and chronic Chagas' disease in central Brazil are described (29 cases 111 cases). geographical distribution Trypanosoma cruzi zymodemes this region was mapped. Zymodeme (Z) 1 identified 12 cases, Z2 13 repeated xenodiagnosis gave the same zymodeme identification. pictures Z1 phases were similar. Resistance to benznidazole treatment occurred after either or infections. Only 14 positive xenodiagnoses obtained from phase patients examined. For these...
ISGlobal work is supported by the Departament d’Universitats i Recerca de la Generalitat Catalunya, Spain (AGAUR; 017SGR00924) and Instituto Salud Carlos III (ISCIII) RICET Network for Cooperative Research in Tropical Diseases (ISCIII; RD16/0027/0004 - PI1290) FEDER. MJP research Ministry of Health, Government Catalonia (PERIS 2016-2010 SLT008/18/00132). ICA, JG, FT are grant number U01AI129783 from National Institute Allergy Infectious (NIAID), Institutes Health (NIH). ICA also partly...
ABSTRACT An enzyme-linked immunosorbent assay to diagnose Chagas' disease by a serological test was performed with Trypanosoma cruzi recombinant antigens (JL8, MAP, and TcPo). High sensitivity (99.4%) specificity (99.3%) were obtained when JL8 combined MAP (JM) tested 150 serum samples from chagasic 142 nonchagasic individuals. Moreover, JM also diagnosed 84.2% of patients in the acute phase T. infection.