A5064068614- Trypanosoma species research and implications
- Cardiomyopathy and Myosin Studies
- Research on Leishmaniasis Studies
- Cardiovascular Function and Risk Factors
- Coenzyme Q10 studies and effects
- Leprosy Research and Treatment
- Parasites and Host Interactions
- Insect symbiosis and bacterial influences
- Synthesis and Biological Evaluation
- Parasitic Diseases Research and Treatment
- Autophagy in Disease and Therapy
- Nail Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Global Public Health Policies and Epidemiology
- Antifungal resistance and susceptibility
- Eosinophilic Esophagitis
- Fungal Infections and Studies
- Gastroesophageal reflux and treatments
- HIV Research and Treatment
- Obesity, Physical Activity, Diet
- Methemoglobinemia and Tumor Lysis Syndrome
- Peripheral Neuropathies and Disorders
- COVID-19 Clinical Research Studies
- Macrophage Migration Inhibitory Factor
- Agriculture and Farm Safety
Instituto Evandro Chagas
2016-2024
Fundação Oswaldo Cruz
2015-2024
National Institutes of Health
2014
Lista de Siglas/Abreviaturas 18 F-FDG – fluordesoxiglicose marcado com flúor-18 123 I-MIBG meta-iodo-benzil-guanidina iodo-123 […] Diretriz da SBC sobre Diagnóstico e Tratamento Pacientes Cardiomiopatia Doença Chagas 2023
To assess the safety of benznidazole use in adult patients with chronic Chagas' disease. The Naranjo algorithm was applied to classify causality adverse drug reactions (ADRs). In total, 190 were treated over a period 4–180 days (mean 58.90 ± 36.54 days) dose 50–500 mg/day (221.33 57.16 mg/day). Of treated, 93 had ADRs and 59 these interrupted treatment. There higher incidence among female young patients. during first 30 Interruption treatment more frequent women. Among who treatment, 39 mild...
Covid-19 is a novel infectious disease whose spectrum of presentation ranges from absence symptoms to widespread interstitial pneumonia associated with severe acute respiratory syndrome (SARS), leading significant mortality. Given the systemic pattern Covid-19, there are many factors that can influence patient's functional capacity after infection and identification such contribute development specific rehabilitation strategies. Pulmonary impairment primary cause hospitalization due progress...
Leprosy is a chronic infectious disease that may present different clinical forms according to the immune response of host. Levels IFN-γ are significantly raised in paucibacillary tuberculoid (T-lep) when compared with multibacillary lepromatous (L-lep) patients. primes macrophages for inflammatory activation and induces autophagy antimicrobial mechanism. The involvement against Mycobacterium leprae remains unexplored. Here, we demonstrated by autophagic assays LC3-positive autophagosomes...
Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin America. Brazil accounts for approximately 80% of cases, where it represents major public health issue due its disabling impact and the number premature deaths causes. We present retrospective cohort study that was conducted in order better understand factors relate cure infection treatment 200 patients with PCM. evaluated influence sociodemographic clinical as well therapeutic regimen (trimethoprim–sulfamethoxazole...
Background The occurrence of adverse drug events (ADEs) during dapsone (DDS) treatment in patients with leprosy can constitute a significant barrier to the successful completion standardized therapeutic regimen for this disease. Well-known DDS-ADEs are hemolytic anemia, methemoglobinemia, hepatotoxicity, agranulocytosis, and hypersensitivity reactions. Identifying risk factors ADEs before starting World Health Organization recommended standard multidrug therapy (WHO/MDT) guide planning...
Benznidazole (BZN) is the main trypanocidal drug used to treat Chagas disease, and evidence supporting benefits of BZN use during chronic phase disease will favor its in millions individuals. However, more than 30% patients treated with may suffer adverse reactions (ADRs), development tools identify those at risk highly desirable. In present study, we aimed predictive factors for ADRs BZN. Among 195 included 48.7% experienced 31.3% had that caused treatment discontinuation. Overall...
The benefit of a cardiac rehabilitation (CR) program for patients with Chagas heart failure (CHF) remains unclear. Therefore, we aimed to investigate the effects CR CHF patients.A single-arm pilot study, including 12 CHF, was performed. Patients participated in an 8-month physical exercise intervention, comprising aerobic, strength, and stretching exercises (3 times per week, 60 minutes session). Nutritional pharmaceutical counseling were also Functional capacity (cardiopulmonary test),...
Up to half of patients with Chagas' disease under benznidazole treatment present adverse drug reactions (ADRs) and up one-third do not complete standard treatment. To verify the incidence possible factors associated suspension in a large cohort patients. We included 2075 treated during projects managed by medical humanitarian organization Doctors Without Borders (Médecins Sans Frontières) Bolivia from 2009 2013. Benznidazole was provided two or three times per day for ∼60 days at 5–7.5...
Background Chagas disease (CD) presents an ominous prognosis. The predictive value of biomarkers and new echocardiogram parameters in adjusted models have not been well studied. Methods Results There were 361 patients with chronic CD (57.6% men, 61±11 years age, clinical forms: indeterminate 27.1%, cardiac 56.6%, digestive 3.6%, cardiodigestive 12.7%) included this single-center, observational, prospective longitudinal study. Echocardiographic evaluation strain analyses left atrial,...
Peripheral neuropathy is the main cause of physical disability in leprosy patients. Importantly, extension and pattern peripheral damage has been linked to how host cell will respond against Mycobacterium leprae ( M. ) infection, particular, pathogen establish infection Schwann cells. Interestingly, viable dead have neuropathology by distinct mechanisms. While promotes transcriptional modifications that allow bacteria survive through use cell's internal machinery subvert metabolites,...
Abstract To investigate the effect of an exercise-based cardiac rehabilitation program on quality life (QoL) patients with chronic Chagas cardiomyopathy (CCC). PEACH study was a single-center, superiority randomized clinical trial exercise training versus no (control). The sample comprised disease CCC, left ventricular ejection fraction < 45%, without or HF symptoms (CCC stages B2 C, respectively). QoL assessed at baseline, after three months, and end six months follow-up using SF-36...
Aims Chronic Chagas disease (ChD) has high morbimortality and loss in quality of life due to heart failure (HF). Pharmaceutical care (PC) optimizes clinical treatment can improve HF. We evaluated if PC improves patients with ChD Methods Single‐blinded, randomized, controlled trial that assigned adult HF (81 patients; 61 ± 11 years; 48% male) ( n = 40) or standard 41). Quality according SF‐36 Minnesota living questionnaires, incidence drug‐related problems (DRPs), adherence medical were...
Most patients with chronic Chagas disease (CD) present the indeterminate form and are at risk to develop cardiac form. However, actual rate of progression is still unknown.In total, 550 CD were followed by means annual electrocardiogram our outpatient clinic. The studied endpoint was defined appearance electrocardiographic changes typical CD. calculated as cumulative incidence per 100 patient years.Thirty-seven progressed within a mean 73 ± 4 8 months follow-up, which resulted in 6.9% 1.48...
Patients with chronic Chagas disease (CD) cardiomyopathy have a high mortality. We evaluated if two-dimensional (2D) strain (ε) parameters provide independent predictors of progression to CD and all-cause A total 408 patients (58.6% women; 53 ± 11 years; clinical forms: indeterminate 34.1%, cardiac 57.6%, digestive 1.2%, cardiodigestive 7.1%) were consecutively included in this single-center prospective longitudinal study. Echocardiographic evaluation left atrial ventricular (LV) function on...
Heart disease progression occurs in 30% of patients with chronic Trypanosoma cruzi infection. Supplementation selenium (Se) animal model T. infection produced promising results. There is evidence that Chagas heart have lower Se levels than healthy individuals and without cardiac disease. The aim this investigation to estimate the effect treatment on prevention chagasic cardiopathy. Selenium Treatment Chagasic Cardiopathy trial a superiority, double-blind, placebo-controlled, randomized...
Leprosy reactions are responsible for incapacities in leprosy and represent the major cause of permanent neuropathy. The identification biomarkers able to identify patients more prone develop reaction could contribute adequate clinical management prevention incapacities. Reversal may occur unstable borderline also lepromatous patients. To biomarker signature profiles related with reversal onset, multibacillary were recruited classified accordingly occurrence or not during after...
Several studies have been focusing on the effect of omega-3 polyunsaturated fatty acids modulation inflammatory markers in several cardiopathies. Although immunoregulatory dysfunction has associated to chronic cardiac involvement Chagas disease, there is no study examining effects supplementation these patients. We investigated PUFAs inflammation and lipid profile cardiomyopathy patients.The present was a single-center double-blind clinical trial including patients with cardiomyopathy....
The increase in life expectancy and the migration of individuals with Chagas disease (ChD) from rural to urban centers exposes them development chronic-degenerative abnormalities that may prevalence metabolic syndrome (MetS). present study aimed identify MetS its components chronic ChD. This is a cross-sectional 361 patients both sexes, aging >18 years, followed at national reference center (Rio de Janeiro, Brazil). diagnosis International Diabetes Federation 2005 criteria. association...
INTRODUCTION We aimed to describe the sociodemographic, epidemiological, and clinical characteristics of patients with chronic Chagas disease (CD) at an infectious referral center. Changes in patient profiles over time were also evaluated. METHODS This retrospective study included CD from November 1986-December 2019. All underwent evaluation protocol that sociodemographic profile; epidemiological history; anamnesis; physical, cardiologic, digestive examinations. Trend differences for each...
Purpose:The aim of the present study was to evaluate effects cardiovascular rehabilitation (CR) on functional capacity patients with chronic chagasic cardiomyopathy (CCC) and compare responses between CCC without heart failure (HF). Materials methods:A longitudinal observational retrospective carried out including 36 HF (stage B2 [n ¼ 7]) C 29]), who participated in a CR program.Functional assessed by maximal progressive cardiopulmonary exercise test performed treadmill.The were determined...
Background We investigated the mortality rates of patients with Chagas disease (CD) during coronavirus 2019 (COVID-19) pandemic and assessed association between this CD clinical presentation comorbidities. Methods: This was an observational retrospective study data retrieved from medical records. Results: Comorbidities were more prevalent among who died COVID-19 than those other causes. The proportion according to similar two groups. Conclusions: prevalence comorbidities seems be related a...
The COVID-19 virus infection caused by the new SARS-CoV-2 was first identified in Rio de Janeiro (RJ), Brazil, March 2020. Until end of 2021, 504,399 cases were confirmed RJ, and total death toll reached 68,347. Evandro Chagas National Institute Infectious Diseases from Oswaldo Cruz Foundation (INI-Fiocruz) is a referral center for treatment research several infectious diseases, including disease (CD). present study aimed to evaluate impact on in-hospital mortality patients with CD during...