A5091469461- Trypanosoma species research and implications
- Cardiomyopathy and Myosin Studies
- Healthcare during COVID-19 Pandemic
- Coenzyme Q10 studies and effects
- Science and Education Research
- Education and Digital Technologies
- Education during COVID-19 pandemic
- Research on Leishmaniasis Studies
- COVID-19 and Mental Health
- Parasites and Host Interactions
- Physical Education and Sports Studies
- Signaling Pathways in Disease
- Heart Failure Treatment and Management
- Lysosomal Storage Disorders Research
- Synthesis and Biological Evaluation
- Cardiovascular Function and Risk Factors
- Galectins and Cancer Biology
- Cancer Cells and Metastasis
- Education Pedagogy and Practices
- COVID-19 Pandemic Impacts
- Mathematical Biology Tumor Growth
- Healthcare professionals’ stress and burnout
- Renal function and acid-base balance
- Infection Control and Ventilation
- Medical and Biological Ozone Research
Fundação Oswaldo Cruz
2016-2025
Faculdades Oswaldo Cruz
2023
Universidade Salgado de Oliveira
2023
Centro de Estudos e Pesquisa em Saúde Coletiva
2023
Instituto de Física La Plata
2023
Universidade Estadual de Montes Claros
2022
International Olive Council
2021
TGF-β involvement in Chagas disease cardiomyopathy has been clearly demonstrated. The signaling pathway is activated the cardiac tissue of chronic phase patients and associated with an increase extracellular matrix protein expression. aim this study was to investigate effect GW788388, a selective inhibitor TβR1/ALK5, on function experimental model Chagas' heart disease. To end, C57BL/6 mice were infected Trypanosoma cruzi (102 parasites from Colombian strain) treated orally 3mg/kg GW788388...
Abstract Background Chagas disease (CD) is a neglected zoonosis that requires study through the One Health approach, as it involves various aspects of animal, environmental, and human health in its transmission cycle. This affects 7 million people 20 countries Latin America, resulting approximately seven thousand deaths annually worldwide. Local knowledge crucial for developing educational strategies to mitigate risks transmission, particularly endemic areas. Aims In this study, we present...
Apresenta uma Arte Instalação cenográfica pedagógica, Por Dentro do Sangue com Arteciência discute aspectos da circulação e dos elementos sanguíneos em condições saudáveis e de doença. Os visitantes caminham por dentro como se estivessem “dentro um vaso sanguíneo” meio experiência imersiva sensorial. A visita foi mediada educador discutindo alguns fase aguda Doença Chagas, quando o parasita Trypanosoma cruzi é encontrado no sangue pessoas infectadas, atraindo a atenção diferentes idades...
Background Chagas disease (CD) presents an ominous prognosis. The predictive value of biomarkers and new echocardiogram parameters in adjusted models have not been well studied. Methods Results There were 361 patients with chronic CD (57.6% men, 61±11 years age, clinical forms: indeterminate 27.1%, cardiac 56.6%, digestive 3.6%, cardiodigestive 12.7%) included this single-center, observational, prospective longitudinal study. Echocardiographic evaluation strain analyses left atrial,...
Chronic Chagasic cardiomyopathy (CCC), a progressive inflammatory and fibrosing disease, is the most prominent clinical form of Chagas neglected tropical disease caused by Trypanosoma cruzi infection. During CCC, parasite remains inside cardiac cells, leading to tissue damage, involving extensive response irregular fibrosis. Among fibrogenic factors transforming growth factor-β (TGF-β), key cytokine controlling extracellular matrix synthesis degradation. TGF-β involved in CCC onset...
Chagas disease (CD) is caused by the flagellate protozoan Trypanosoma cruzi . It endemic in Latin America. Nowadays around 6 million people are affected worldwide, and 75 still at risk. CD has two evolutive phases, acute chronic. The phase mostly asymptomatic, or presenting unspecific symptoms which makes it hard to diagnose. At chronic phase, patients can stay indeterminate form develop cardiac and/or digestive manifestations. trypanocide drugs available for treatment of benznidazole (BZ)...
Breast cancer is the most prevalent among women worldwide. Therapeutic strategies to control tumors and metastasis are still challenging. Three-dimensional (3D) spheroid-type systems more accurately replicate features of in vivo, working as a better platform for performing therapeutic response analysis. This work aimed characterize epithelial-mesenchymal transition doxorubicin (dox) mammary tumor spheroid (MTS) model. We evaluated treatment effect on MCF-7 diameter, cell viability, death,...
Aims Chronic Chagas disease (ChD) has high morbimortality and loss in quality of life due to heart failure (HF). Pharmaceutical care (PC) optimizes clinical treatment can improve HF. We evaluated if PC improves patients with ChD Methods Single‐blinded, randomized, controlled trial that assigned adult HF (81 patients; 61 ± 11 years; 48% male) ( n = 40) or standard 41). Quality according SF‐36 Minnesota living questionnaires, incidence drug‐related problems (DRPs), adherence medical were...
Transforming growth factor beta (TGF-β) is deeply involved on the pathogenesis of Chagas disease. Our group has been investigating participation this pleiotropic cytokine in different aspects disease over last 20 years. Important observations have made, such as: (i) ability Trypanosoma cruzi activating latent TGF-β; (ii) potential involvement TGF-β pathway T. invasion host cells; (iii) association with parasite intracellular replication; (iv) cardiac fibrosis development and maintenance; (v)...
Trata-se de um relato experiência desenvolvido com grupo educadores, estudantes e interessados nas tecnologias informação comunicação, especificamente, durante o período pandemia da Covid-19. Objetivou-se apresentar as plataformas Zoom Streamyard, avaliar a usabilidade pelos participantes, identificando contexto, no qual, poderão ser utilizadas, forma mais adequada para ensino. A oficina teve duração 150 minutos pelo em dezembro 2020, 19 participantes. Fizemos detalhamento técnico do...
To evaluate the correlation of total distance walked during six-minute walk test (6MWT) with left ventricular function and quality life in patients Chagas Disease (ChD) complicated by heart failure.This is a cross-sectional study adult ChD failure diagnosed based on Framingham criteria. 6MWT was performed following international guidelines. New York Heart Association functional class, brain natriuretic peptide (BNP) serum levels, echocardiographic parameters (SF-36 MLHFQ questionnaires) were...
Chagas Disease (CD) affects 6-7 million people worldwide and is related to poverty-promoting conditions. Chronic asymptomatic cases are mostly invisible health systems. Aiming (1) translate CD discoveries into education/information practices raise alertness empowerment of affected people; (2) perform an active search cases, articulating intersectoral actions improve the access infected local service for treatment CD; our research group developed tested under field conditions as innovative...
Neurological commitment is a neglected manifestation of Chagas disease (CD). Meningoencephalitis mainly affects children and immunosuppressed patients, while stroke can occur with or without cardiac compromise. One the possible causes development microvascular commitment. Our group previously described that experimental Trypanossoma cruzi acute infection leads to cerebral microvasculopathy. This condition characterized by decreased capillary density, increased leukocyte rolling adhesion,...
Transforming growth factor β1 (TGF-β1) and tumour necrosis (TNF) have been implicated in Chagas disease pathophysiology may correlate with left ventricular (LV) function.We determined whether TGF-β1 TNF serum levels LV systolic diastolic functions brain natriuretic peptide (BNP) chronic disease.This cross-sectional study included 152 patients (43% men; 57 ± 12 years old), classified as 53 indeterminate form 99 cardiac (stage A: 24, stage B: 25, C: 44, D: 6). TGF-β1, TNF, BNP were by...
Transforming growth factor β 1 (TGF- 1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF- serum levels show a worse clinical outcome. Gene polymorphism may account for differences cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associated disease susceptibility and severity Brazilian population. investigated five single-nucleotide (−800 G>A, −509 C>T, +10 T>C, +25 G>C, +263 C>T). 152 (53 the...
The importance of health professionals has been recognized in COVID-19 pandemic-affected countries, especially those such as Brazil, which is one the top 3 countries that have affected world. However, workers' perception stress and changes pandemic caused their lives vary according to conditions offered by these including salaries, individual protection equipment, psychological support.
Chagas disease (CD) caused by Trypanosoma cruzi is a neglected illness and major reason for cardiomyopathy in endemic areas. The existing therapy generally involves trypanocidal agents therapies that control cardiac alterations. However, there no treatment the progressive remodeling characterized inflammation, microvasculopathy extensive fibrosis. Thus, search new therapeutic strategies aiming to inhibit progression of injury failure necessary. Vascular Endothelial Growth Factor A (VEGF-A)...