A5037279431- Trypanosoma species research and implications
- Cardiomyopathy and Myosin Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Mitochondrial Function and Pathology
- Biomarkers in Disease Mechanisms
- interferon and immune responses
- Galectins and Cancer Biology
- Research on Leishmaniasis Studies
- Viral Infections and Immunology Research
- Mast cells and histamine
- Balance, Gait, and Falls Prevention
- Advanced Control Systems Optimization
- Phytochemistry Medicinal Plant Applications
- Vehicle Dynamics and Control Systems
- Muscle activation and electromyography studies
- Lysosomal Storage Disorders Research
- COVID-19 epidemiological studies
- Circular RNAs in diseases
- Structural Integrity and Reliability Analysis
- Cell Image Analysis Techniques
- vaccines and immunoinformatics approaches
- Milk Quality and Mastitis in Dairy Cows
- Fluid Dynamics Simulations and Interactions
- SARS-CoV-2 detection and testing
Universidade Federal de São Paulo
2024
University of Minho
2024
Inserm
2021-2023
Aix-Marseille Université
2021-2023
Universidade de São Paulo
2020-2023
Theories and Approaches of Genomic Complexity
2021-2023
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018-2023
Hospital do Coração
2022-2023
Instituto Politécnico de Lisboa
2021
Universidade Federal de Minas Gerais
2013-2021
Lista de Siglas/Abreviaturas 18 F-FDG – fluordesoxiglicose marcado com flúor-18 123 I-MIBG meta-iodo-benzil-guanidina iodo-123 […] Diretriz da SBC sobre Diagnóstico e Tratamento Pacientes Cardiomiopatia Doença Chagas 2023
Chagas disease is caused by infection with the protozoan Trypanosoma cruzi and affects over 8 million people worldwide. In spite of a powerful innate adaptive immune response in acute infection, parasite evades eradication, leading to chronic persistent low parasitism. Chronically infected subjects display differential patterns progression. While 30% develop cardiomyopathy (CCC) – severe inflammatory dilated decades after 60% patients remain disease-free, asymptomatic/indeterminate (ASY)...
Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy (CCC) and can lead to arrhythmia, heart failure death. affects 8 million people worldwide, chronic production of cytokines IFN-γ TNF-α T cells together with mitochondrial dysfunction are important players for poor prognosis disease. Mitochondria occupy 40% cardiomyocytes volume produce 95% cellular ATP that sustain life-long cycles contraction. As have been described affect function, we hypothesized involved in...
CoronaVac is an inactivated SARS-CoV-2 vaccine that has been rolled out in several low and middle-income countries including Brazil, where it was the mainstay of first wave immunization healthcare workers elderly population. We aimed to assess T cell antibody responses vaccinated individuals as compared convalescent patients. detected IgG against antigens, neutralizing antibodies reference Wuhan strain used peptides detect IFN-g IL-2 specific a group (N = 101) 72) individuals. The frequency...
Recent advances in biological imaging techniques and the enormous amount of data they generate call for development computational tools efficient reliable high-throughput analysis. Several software applications with this functionality are available, one most commonly used is ImageJ. Here, we present two independent macros (WH_NJ SA_NJ) automating facilitating analysis images acquired from vitro assays frequently cancer studies drug screening: wound-healing soft-agar assays. These algorithms...
Chronic Chagas disease cardiomyopathy (CCC), an especially aggressive inflammatory dilated caused by lifelong infection with the protozoan Trypanosoma cruzi, is a major cause of in Latin America. Although chronic myocarditis may play pathogenetic role, little known about molecular mechanisms responsible for its severity. The aim this study to genes and microRNAs expression tissues their connections regards pathobiological processes. To do so, we integrated first time global microRNA mRNA...
ABSTRACT Background Clinical recurrence of COVID-19 in convalescent patients has been reported, which immune mechanisms have not thoroughly investigated. Presence neutralizing antibodies suggests other types response are involved. Methods We assessed the innate type I/III IFN response, T cell responses to SARS-CoV-2 with IFNγ ELISPOT, binding and antibody assays, two monozygotic twin pairs one case. Results In pair 1, four months after a first mild episode infection for both siblings,...
Fibrosarcomas are soft tissue mesenchymal tumors originating from transformed fibroblasts. Fibroblast growth factor-2 (FGF2) and its tyrosine-kinase receptors (FGFRs) play pivotal roles in fibrosarcoma onset progression, FGF2 being actively produced by fibroblasts all stages along their malignant transformation to the stage. The soluble pattern recognition receptor long pentraxin-3 (PTX3) is an extrinsic oncosuppressor whose expression reduced different tumor types, including sarcomas, via...
Abstract Cardiomyopathies are an important cause of heart failure and sudden cardiac death. Little is known about the role rare genetic variants in inflammatory cardiomyopathy. Chronic Chagas disease cardiomyopathy (CCC) prevalent Latin America, developing 30% 6 million patients chronically infected by protozoan Trypanosoma cruzi , while 60% remain free (asymptomatic (ASY)). The cytokine interferon-γ mitochondrial dysfunction to play a major pathogenetic role. provides unique model probe for...
Chagas disease cardiomyopathy (CCC) is an inflammatory dilated occurring in 30% of the 6 million infected with protozoan Trypanosoma cruzi Latin America. Survival significantly lower CCC than ischemic (IC) and idiopathic (DCM). Previous studies disclosed a selective decrease mitochondrial ATP synthase alpha expression creatine kinase activity myocardium as compared to IDC IC, well decreased vivo myocardial production. Aiming identify additional constraints energy metabolism specific CCC, we...
Chagas disease, caused by the protozoan Trypanosoma cruzi, is an endemic parasitic disease of Latin America, affecting 7 million people. Although most patients are asymptomatic, 30% develop complications, including often-fatal Chronic Chagasic Cardiomyopathy (CCC). previous studies have demonstrated some genetic deregulations associated with CCCs, causes their remain poorly described. Based on bulk RNA-seq and whole genome DNA methylation data, we investigated epigenetic present in moderate...
SARS-CoV2 virus, responsible for the COVID-19 pandemic, has four structural proteins and 16 nonstructural proteins. S-protein is one of exposed on virus surface main target producing neutralizing antibodies vaccines. The forms a trimer that can bind angiotensin-converting enzyme 2 (ACE2) through its receptor binding domain (RBD) cell entry.
Recurrence of COVID-19 in recovered patients has been increasingly reported. However, the immune mechanisms behind recurrence have not thoroughly investigated. The presence neutralizing antibodies (nAbs) recurrence/reinfection cases suggests that other types response are involved protection against recurrence. Here, we investigated innate type I/III interferon (IFN) response, binding and nAb assays T-cell responses to severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) with...
Chagas disease is a parasitic from South America, affecting around 7 million people worldwide. Decades after the infection, 30% of develop chronic forms, including Chronic Cardiomyopathy (CCC), for which no treatment exists. Two stages characterized this form: moderate form, by heart ejection fraction (EF) ≥ 0.4, and severe associated to an EF < 0.4. We propose two sets DNA methylation biomarkers can predict in blood CCC occurrence, stage. This analysis, based on machine learning algorithms,...
Slip-related falls are a significant concern, particularly for vulnerable populations such as the elderly and individuals with gait disorders, necessitating effective preventive measures. This manuscript presents biomechanical study of how lower limbs react to perturbations that can trigger slip-like fall, ultimate goal identifying target specifications developing wearable robotic system fall prevention.
Cardiomyopathies are major causes of heart failure. Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it endemic in Central, South America. Thirty percent cases evolve into chronic cardiomyopathy (CCC) with worse prognosis as compared other cardiomyopathies. In vivo bioenergetic analysis ex proteomic myocardial tissues highlighted mitochondrial dysfunction CCC, previous studies identified nuclear-encoded gene variants segregating CCC. Here, we assessed role genome through...
Chagas disease (CD), caused by the protozoan parasite Trypanosoma cruzi, affects 8 million people, and around 1/3 develop chronic cardiac (CCC) or digestive (megaesophagus/megacolon), while majority remain asymptomatic, in indeterminate form of (ASY). Most CCC cases families with multiple patients carry damaging mutations mitochondrial genes. We searched for exonic associated to chagasic megaesophagus (CME) genes essential processes. performed whole exome sequencing 13 CME 45 ASY patients....
This paper summarizes the work of CAMEPP, IST Commission that was charged in 2018 with analysis pedagogical practice at IST, as well curricula its first and second cycle degrees. As a consequence this work, changed significantly curricular structure degrees methods, new design will begin implementation 2021/22.