A5028371503- Mosquito-borne diseases and control
- Mycobacterium research and diagnosis
- interferon and immune responses
- Viral Infections and Vectors
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Autoimmune and Inflammatory Disorders Research
- Vibrio bacteria research studies
- Viral Infections and Immunology Research
- Galectins and Cancer Biology
- Trypanosoma species research and implications
- Immune responses and vaccinations
Universidade de São Paulo
2020-2024
Chronic Chagas disease cardiomyopathy (CCC), an especially aggressive inflammatory dilated caused by lifelong infection with the protozoan Trypanosoma cruzi, is a major cause of in Latin America. Although chronic myocarditis may play pathogenetic role, little known about molecular mechanisms responsible for its severity. The aim this study to genes and microRNAs expression tissues their connections regards pathobiological processes. To do so, we integrated first time global microRNA mRNA...
ABSTRACT In the 2018 yellow fever (YF) outbreak in Brazil, we generated new transcriptomic data and combined it with clinical immunological to decode pathogenesis of YF. Analyzing 79 patients, found distinct gene expression patterns between acute YF, other viral infections, milder YF‐17D vaccine infection. We identified a critical role for low‐density, immature neutrophils severe outcomes, marked by downregulation genes essential neutrophil migration maturation, such as PADI4, CSF3R, ICAM1,...
Summary In the 2018 yellow fever (YF) outbreak in Brazil, we generated new transcriptomic data and combined it with clinical immunological to decode pathogenesis of YF. Our analysis 79 patients highlighted distinct gene expression patterns between acute YF infections, other viral milder infection induced by live-attenuated YF-17D vaccine. We identified a critical role for low-density, immature neutrophils severe outcomes, marked downregulation genes such as PADI4, CSF3R, ICAM1 deceased...
Infection with the Chikungunya virus (CHIKV) manifests as a febrile illness known chikungunya fever (CHIKF). CHIKF is characterized by sudden-onset high fever, rash, polyarthritis, and polyarthralgia. Alt-hough infection typically resolves within two weeks, many patients experience recurrent joint pain inflammation that can outlast other symptoms for months. has been previously linked to rheumatoid arthritis (RA) due similar inflammatory processes. This study aimed identify molecular markers...
Chikungunya fever (CHIKF), caused by the virus (CHIKV), manifests as acute febrile illness often associated with polyarthritis and polyarthralgia. Although symptoms resolve within two weeks, many patients experience prolonged joint pain inflammation, resembling rheumatoid arthritis (RA). This study aimed to identify molecular markers related chronicity in CHIKV-infected individuals analyzing blood transcriptomes using bulk RNA sequencing. B- T-cell receptor (BCR TCR) diversity was assessed...
Pathogens can cause a wide variety of infectious diseases. The biological processes induced by the host in response to infection determine severity disease. To study such processes, researchers use high-throughput sequencing techniques (RNA-seq) that measure dynamic changes transcriptome at different stages infection, clinical outcomes, or disease severity.This investigation lead better understanding diseases, as well uncovering potential drug targets and treatments. protocol presented here...
Pathogens can cause a wide variety of infectious diseases. The biological processes induced by the host in response to infection determine severity disease. To study such processes, researchers use high-throughput sequencing techniques (RNA-seq) that measure dynamic changes transcriptome at different stages infection, clinical outcomes, or disease severity.This investigation lead better understanding diseases, as well uncovering potential drug targets and treatments. protocol presented here...