A5052842395- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Vibrio bacteria research studies
- Virology and Viral Diseases
- Nutrition and Health in Aging
- vaccines and immunoinformatics approaches
- Diet and metabolism studies
- Infectious Encephalopathies and Encephalitis
- Vitamin C and Antioxidants Research
- Neonatal Respiratory Health Research
- Invertebrate Immune Response Mechanisms
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- Clinical Nutrition and Gastroenterology
- Immune responses and vaccinations
- Digital Imaging for Blood Diseases
Universidade de São Paulo
2016-2025
Associação Brasileira de Alergia e Imunologia
2021-2022
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2022
Instituto Adolfo Lutz
2019
ABSTRACT Yellow fever (YF) is classically conceptualized as a hepatotropic disease; indeed, the liver primary site of yellow virus (YFV) replication. However, circumstantial evidence suggests that extra-hepatic disease may be important for ∼30% YF cases progress to severe “intoxication” phase disease. Using Syrian hamster-adapted (HA)-YFV, we worked backwards from observations in humans examine early events precipitate intoxication YF. HA-YFV caused ∼80% infected animals characterized by...
Coronavac is a widely used SARS-CoV-2 inactivated vaccine, but its long-term immune response assessment still lacking. We evaluated SARS-CoV-2-specific responses, including T cell activation markers, antigen-specific cytokine production and antibody following vaccination in 53 adult elderly individuals participating phase 3 clinical trial. Activated follicular helper (Tfh), non-Tfh memory CD4 + cells were detected almost all subjects early after the first vaccine dose. predominantly of...
In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with high fatality rate. Yellow virus can cause, among other symptoms, haemorrhage and disseminated intravascular coagulation, indicating role for endothelial cells the disease pathogenesis. Here, we conducted case-control study measured markers related to damage plasma its association mortality. We found that angiopoietin-2 is strongly associated fatal outcome could serve as predictive marker This be used monitor severe...
Abstract Background Yellow fever is a mosquito-borne zoonotic disease caused by yellow virus (YFV). Between 2017 and 2019, more than 504 human cases 176 deaths were confirmed in the outskirts of São Paulo city. Throughout this outbreak, studies suggested potential association between YFV viremia mortality. Methods Viral ribonucleic acid was measured using reverse-transcription quantitative polymerase chain reaction plasma samples collected at up to 5 time points, 3 120 days after symptoms...
ABSTRACT In the 2018 yellow fever (YF) outbreak in Brazil, we generated new transcriptomic data and combined it with clinical immunological to decode pathogenesis of YF. Analyzing 79 patients, found distinct gene expression patterns between acute YF, other viral infections, milder YF‐17D vaccine infection. We identified a critical role for low‐density, immature neutrophils severe outcomes, marked by downregulation genes essential neutrophil migration maturation, such as PADI4, CSF3R, ICAM1,...
An effective vaccine against the dengue virus (DENV) should induce a balanced, long-lasting antibody (Ab) response all four viral serotypes. The burst of plasmablasts in peripheral blood after vaccination may reflect enriched vaccine-specific Ab secreting cells. Here we characterize acute plasmablast responses from naïve and DENV-exposed individuals following immunization with live attenuated tetravalent (LAT) Butantan DENV (Butantan-DV). frequency circulating was determined by flow...
Summary In the 2018 yellow fever (YF) outbreak in Brazil, we generated new transcriptomic data and combined it with clinical immunological to decode pathogenesis of YF. Our analysis 79 patients highlighted distinct gene expression patterns between acute YF infections, other viral milder infection induced by live-attenuated YF-17D vaccine. We identified a critical role for low-density, immature neutrophils severe outcomes, marked downregulation genes such as PADI4, CSF3R, ICAM1 deceased...
The Sinovac SARS-CoV-2 inactivated vaccine (CoronaVac) has been demonstrated to be safe, well tolerated, and efficacious in preventing mild severe Covid-19. Although different studies have its short-term immunogenicity, long-term cellular humoral response evaluations are still lacking.
Summary The resurgence of yellow fever in South America has prompted mitigation through vaccination against the etiologic agent, virus (YFV). Current vaccines are based on a virulent African isolate, and their capacity to induce neutralizing antibodies vaccine strain is widely used as surrogate for protection. However, sensitivity genetically distinct American strains vaccine-induced unknown. Here, we show that antiviral potency polyclonal antibody response both U.S. Brazilian vaccinees...
Abstract Pertussis resurgence worldwide calls for new prevention strategies, as the recently incorporated vaccine booster dose during pregnancy, whose aim is to protect newborns from infection. In Brazil, maternal Tdap vaccination recommended since 2014, and we reported that this strategy promotes high transplacental transfer of anti-PT IgG it effective in protecting infants early life. Young children are most susceptible group with higher mortality rates, however, not well known whether...