A5114375037- Malaria Research and Control
- Trypanosoma species research and implications
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Viral Infections and Immunology Research
- Research on Leishmaniasis Studies
- Tuberculosis Research and Epidemiology
- Galectins and Cancer Biology
- Cytokine Signaling Pathways and Interactions
- Liver Disease Diagnosis and Treatment
- Complement system in diseases
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Liver physiology and pathology
- Immunodeficiency and Autoimmune Disorders
- RNA modifications and cancer
- HIV Research and Treatment
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- Connective Tissue Growth Factor Research
- Eosinophilic Disorders and Syndromes
- Whipple's Disease and Interleukins
- Cutaneous lymphoproliferative disorders research
- Liver Diseases and Immunity
- Lysosomal Storage Disorders Research
Inserm
2006-2022
Aix-Marseille Université
2008-2022
Génétique et Immunologie des Maladies Parasitaires
2006-2022
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2021
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020
Institut de Biologie et de Chimie des Protéines
2006-2016
Université Claude Bernard Lyon 1
2016
Assistance Publique Hôpitaux de Marseille
2009
Institut de Microbiologie de la Méditerranée
2009
Institut de Neurobiologie de la Méditerranée
2008-2009
IL-17 and IL-22 have been shown to increase protection against certain bacteria fungal pathogens in experimental models. However, no human studies demonstrated a crucial role of infections. We show here that Leishmania donovani, which can cause the lethal visceral disease Kala Azar (KA), stimulates differentiation Th17 cells, produce IL-17, IL-22, IFN-gamma. Analysis Th1, Th2, cytokine responses by cultured PBMCs from individuals cohort subjects who developed KA or were protected during...
Interleukin (IL)‐22 acts on epithelia, hepatocytes, and pancreatic cells stimulates innate immunity, tissue protection, repair. IL‐22 may also cause inflammation abnormal cell proliferation. The binding of to its receptor is competed by protein (IL‐22BP), which limit the deleterious effects IL‐22. role IL‐22BP in chronic liver diseases unknown. We addressed this question individuals chronically infected with schistosomes or hepatitis C virus (HCV). first demonstrate that schistosome eggs...
Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America and affects 10 million people worldwide. Approximately 12000 deaths attributable to disease occur annually due chronic cardiomyopathy (CCC), an inflammatory presenting with heart failure arrythmia; 30% of infected subjects develop CCC years after infection. Genetic mechanisms play a role differential progression CCC, but little known about epigenetic modifications pathological gene expression patterns...
Abnormal fibrosis occurs during chronic hepatic inflammations and is the principal cause of death in hepatitis C virus schistosome infections. Hepatic (HF) may develop either slowly or rapidly schistosome-infected subjects. This depends, part, on a major genetic control exerted by genes chromosome 6q23. A gene (connective tissue growth factor [CTGF]) located that region encodes strongly fibrogenic molecule. We show single nucleotide polymorphism (SNP) rs9402373 lies close to CTGF associated...
Schistosoma eggs cause chronic liver inflammation and a complex disease characterized by hepatic fibrosis (HF) splenomegaly (SplM). FOXP3+ Tregs could regulate inflammation, but it is unclear where these cells are produced what roles they play in human schistosomiasis. We investigated blood spleen Chinese fishermen with lifelong exposure to japonicum various degrees of disease. accounted for 4.3% CD4+ T 41.2% FOXP3+CD4+ cells; be divided into CD45RA-FOXP3hi effector (eTregs) CD45RA+FOXP3low...
Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of lncRNA known as myocardial infarction–associated transcript (MIAT) has been associated with infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated role MIAT in CCC. A whole-transcriptome analysis heart biopsy specimens formalin-fixed, paraffin-embedded samples revealed that was overexpressed patients...
Chagas disease, caused by the parasite Trypanosoma cruzi, is endemic in Latin America. Its acute phase associated with high parasitism, myocarditis and profound myocardial gene expression changes. A chronic ensues where 30% develop severe heart lesions. Mouse models of T. cruzi infection have been used to study damage disease. The aim this was provide an interactome between miRNAs their targetome disease integrating microRNA profiling data from hearts infected mice. Gene revealed enrichment...
Chronic Chagas disease cardiomyopathy (CCC), an especially aggressive inflammatory dilated caused by lifelong infection with the protozoan Trypanosoma cruzi, is a major cause of in Latin America. Although chronic myocarditis may play pathogenetic role, little known about molecular mechanisms responsible for its severity. The aim this study to genes and microRNAs expression tissues their connections regards pathobiological processes. To do so, we integrated first time global microRNA mRNA...
BackgroundThe pathogenic mechanisms of cerebral malaria (CM) are unclear but thought to involve cytokine-mediated inflammation enhanced by parasite sequestration in the brain microcirculation. The role that interferon (IFN)–γ could play would enhance also reduce parasitemia is
The role of the Th1 pathway in pathogenesis severe malaria is unclear. We recently reported that a polymorphism with increasing IFNG transcription associated protection against cerebral (CM). Interleukin-12 required for cell differentiation, which characterized by production interferon-γ. investigated 21 markers IL12-related genes, including IL12A and IL12B encoding two IL-12 (IL12p70) subunits, IL12p35 IL12p40. performed family-based association study using total sample set 240 nuclear...
The mitotic cyclin Clb2 plays a major role in promoting M-phase budding yeast, despite its functional redundancy with three closely related cyclins Clb1, Clb3 and Clb4. Here, we further investigate the mechanisms controlling cellular distribution of living cells. In agreement observations recently made by Hood et al. [Hood, J. K., Hwang, W. Silver, P. A. (2001) Cell Sci. 114, 589-597], find that GFP-tagged expressed from natural promoter localizes to various compartments, including nucleus,...
Severe malaria (SM) due to Plasmodium falciparum causes millions of child deaths in sub-Saharan Africa. It comprises a variety clinical disorders, including cerebral (CM) and severe anemia (SA). In previous work, we have shown that interferon gamma interleukin 12 protect against CM. Here, investigated whether 4 (IL-4) aggravates the risk disease.We prospectively recruited children with CM (n = 240), SA 101), uncomplicated (UM) 42) Bamako, Mali, measured IL-4 production plasma by...
Background: The population exposed to malaria within African cities has steadily increased. However, comprehensive data on life-threatening features and risk factors in children from urban areas with seasonal transmission, such as Bamako (Mali), are lacking. Methods: Children admitted the Gabriel Touré Hospital severe malarial anemia (SMA) and/or cerebral (CM) were prospectively included study. Indicators of either SMA or CM analyzed using logistic regression; death hazard ratios (HRs)...
Abstract The outcome of Leishmania infections varies substantially, depending on the host and parasite strain; infection may be asymptomatic or cause mild severe skin ulcers (cutaneous leishmaniasis [CL]), limited disseminated lesions, lethal visceral disease. We previously reported an association between IL-2R mutations susceptibility to in children infected with donovani. In present study, we evaluated possible role IL-2 signaling human CL. first showed that transcripts several genes...
ABSTRACT Cerebral malaria (CM) is a neurological complication of infection with Plasmodium falciparum that partly caused by cytokine-mediated inflammation. It not known whether interleukin-17 (IL-17) cytokines, which regulate inflammation, control the development CM. To evaluate involvement IL-17 cytokines in CM, we analyzed 46 common polymorphisms IL17A , IL17F and IL17RA (which encodes receptor chain members family) two independent African populations. A case-control study involving 115...
Background Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America. Thirty percent of infected individuals develop chronic cardiomyopathy (CCC), an inflammatory dilated that most important clinical consequence T. cruzi infection, while others remain asymptomatic (ASY). IFN- and IFN--producing Th1-type T cells are increased peripheral blood CCC myocardium as compared to ASY patients, Th1-antagonizing cytokine IL-10 more expressed patients. Importantly frequent...
ABSTRACT The hypothesis that tumor necrosis factor (TNF) aggravates malaria in children is supported by observations TNF polymorphisms and high levels have been associated with cerebral malaria. Nevertheless, severe was not located at positions −308A −238A the alpha gene promoter or a level plasma from Bamako, Mali.
Cerebral malaria (CM), a reversible encephalopathy affecting young children, is medical emergency requiring rapid clinical assessment and treatment. However, understanding of the genes/proteins biological pathways involved in disease outcome still limited.We have performed whole transcriptomic analysis blood samples from Malian children with CM or uncomplicated (UM). Hierarchical clustering pathway, network, upstream regulator analyses were to explore differentially expressed genes (DEGs)....
Chagas disease, caused by the protozoan Trypanosoma cruzi, is an endemic parasitic disease of Latin America, affecting 7 million people. Although most patients are asymptomatic, 30% develop complications, including often-fatal Chronic Chagasic Cardiomyopathy (CCC). previous studies have demonstrated some genetic deregulations associated with CCCs, causes their remain poorly described. Based on bulk RNA-seq and whole genome DNA methylation data, we investigated epigenetic present in moderate...
Cerebral malaria, a reversible encephalopathy affecting young children, is medical emergency requiring urgent clinical assessment and treatment. We performed whole-transcriptomic analysis of blood samples from Malian children with cerebral or uncomplicated malaria. focused on transcripts pathways for which dysfunction has been associated neurodegenerative disorders. found that SNCA, SIAH2, UBB, HSPA1A, TUBB2A, PINK1 were upregulated (fold-increases, ≥2.6), whereas UBD PSMC5 downregulated...