A5048856583- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Streptococcal Infections and Treatments
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Cardiac and Coronary Surgery Techniques
- Viral Infections and Immunology Research
- Cardiac Arrhythmias and Treatments
- Transplantation: Methods and Outcomes
- Cardiovascular Function and Risk Factors
- Antimicrobial Resistance in Staphylococcus
- Cardiovascular Issues in Pregnancy
- Trypanosoma species research and implications
- Cardiac tumors and thrombi
- Atrial Fibrillation Management and Outcomes
- Coronary Artery Anomalies
- Mechanical Circulatory Support Devices
- Inflammasome and immune disorders
- Cardiac Arrest and Resuscitation
- Pericarditis and Cardiac Tamponade
- Cardiomyopathy and Myosin Studies
Universidade de São Paulo
2015-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2010-2024
Instituto do Coração
1992-2024
Associação Fundo de Incentivo à Pesquisa
2023
Hospital do Coração
1999-2021
Interamerican Society of Cardiology
2020
Sociedade Brasileira de Cardiologia
2020
Hospital São Paulo
2019
National Heart Institute
2001-2016
Committee on Publication Ethics
2016
Perioperative red blood cell transfusion is commonly used to address anemia, an independent risk factor for morbidity and mortality after cardiac operations; however, evidence regarding optimal practice in patients undergoing surgery lacking.To define whether a restrictive perioperative strategy as safe liberal elective surgery.The Transfusion Requirements After Cardiac Surgery (TRACS) study, prospective, randomized, controlled clinical noninferiority trial conducted between February 2009...
Vasoplegic syndrome is a common complication after cardiac surgery and impacts negatively on patient outcomes. The objective of this study was to evaluate whether vasopressin superior norepinephrine in reducing postoperative complications patients with vasoplegic syndrome.This prospective, randomized, double-blind trial conducted at the Heart Institute, University Sao Paulo, Brazil, between January 2012 March 2014. Patients shock (defined as mean arterial pressure less than 65 mmHg resistant...
Background β-Hemolytic streptococcal infection in developing countries still causes thousands of cases rheumatic heart disease, demanding surgical valve correction. Antigenic mimicry between self and components has been proposed as the triggering factor leading to autoimmunity individuals with genetic susceptibility. Although streptococcal–M protein cross-reactive antibodies have demonstrated, tissue damage seems be T lymphocyte–dependent. We studied infiltrating lymphocytes lesions aim...
We hypothesized that reactive oxygen species (ROS) contribute to progression of aortic valve (AV) calcification/stenosis.We investigated ROS production and effects antioxidants tempol lipoic acid (LA) in calcification rabbits given 0.5% cholesterol diet +10(4) IU/d Vit.D2 for 12 weeks. Superoxide H2O2 microfluorotopography 3-nitrotyrosine immunoreactivity showed increased signals not only macrophages but preferentially around calcifying foci, cells expressing osteoblast/osteoclast,...
Abstract Molecular mimicry between Streptococcus pyogenes Ags and human proteins has been considered as a mechanism leading to autoimmune reactions in rheumatic fever heart disease (RHD). Cardiac myosin shown putative autoantigen recognized by autoantibodies of patients. We assessed the heart-intralesional T cell response against light meromyosin (LMM) streptococcal M5 peptides mitral-valve-derived proliferation assay. Cytokines induced LMM were also evaluated. The frequency intralesional...
1. Introduction There are currently a wide modalities of interventional strategies – both transcatheter and surgical which can be indicated for patients with valvular heart diseases (VHD), the objective reducing morbidity mortality. The correct timing indication type treatment linked to precise anatomical functional diagnosis VHD, comprehensive global evaluation patient. 2020 Update Brazilian Guidelines in addition compiling [...]
The optimal treatment in patients with severe aortic stenosis and small annulus (SAA) remains to be determined. This study aimed compare the hemodynamic clinical outcomes between transcatheter valve replacement (TAVR) surgical (SAVR) a SAA.
Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy (CCC) and can lead to arrhythmia, heart failure death. affects 8 million people worldwide, chronic production of cytokines IFN-γ TNF-α T cells together with mitochondrial dysfunction are important players for poor prognosis disease. Mitochondria occupy 40% cardiomyocytes volume produce 95% cellular ATP that sustain life-long cycles contraction. As have been described affect function, we hypothesized involved in...
ABSTRACT T-cell molecular mimicry between streptococcal and heart proteins has been proposed as the triggering factor leading to autoimmunity in rheumatic disease (RHD). We searched for immunodominant M5 epitopes among RHD patients with defined clinical outcomes compared reactivities of peripheral blood intralesional T cells from severe RHD. The role HLA class II molecules presentation peptides was also evaluated. studied reactivity against on mononuclear (PBMC) 74 grouped according severity...
Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America and affects 10 million people worldwide. Approximately 12000 deaths attributable to disease occur annually due chronic cardiomyopathy (CCC), an inflammatory presenting with heart failure arrythmia; 30% of infected subjects develop CCC years after infection. Genetic mechanisms play a role differential progression CCC, but little known about epigenetic modifications pathological gene expression patterns...
1. Introducao O Departamento de Cardiologia da Mulher (DCM) apresenta este documento, elaborado acordo com as normas estabelecidas pela Sociedade Brasileira (SBC), a finalidade discutir sobre patologias cardiovasculares mais prevalentes que acometem mulher durante o ciclo gravidico-puerperal e para quais nao existem evidencias substanciais ou ensaios clinicos randomizados. Com apoio SBC, entao Cardiopatia Gravidez publicou, em 1999, 1° Consenso Planejamento [...]
Rheumatic heart disease (RHD) is a sequel of post-streptococcal throat infection. Molecular mimicry between streptococcal and components has been proposed as the triggering factor disease, CD4(+) T cells have found predominantly at pathological sites in RHD patients. These infiltrating are able to recognize M protein peptides, involving mainly 1-25, 81-103 163-177 N-terminal amino acids residues. In present work we focused on TCR beta chain family (TCR BV) usage degree clonality assessed by...
Autoimmune inflammatory reactions leading to rheumatic fever (RF) and heart disease (RHD) result from untreated Streptococcus pyogenes throat infections in individuals who exhibit genetic susceptibility. Immune effector mechanisms have been described that lead tissue damage culminating mitral aortic valve dysfunctions. In myxomatous degeneration (MXD), the is also damaged due non-inflammatory mechanisms. Both diseases are characterized by structural disarray a previous proteomic analysis of...
Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of lncRNA known as myocardial infarction–associated transcript (MIAT) has been associated with infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated role MIAT in CCC. A whole-transcriptome analysis heart biopsy specimens formalin-fixed, paraffin-embedded samples revealed that was overexpressed patients...
Rheumatic fever (RF) is an autoimmune disease triggered by Streptococcus pyogenes infection frequently observed in infants from developing countries. heart (RHD), the major sequel of RF, leads to chronic inflammation myocardium and valvular tissue. T cells are main population infiltrating cardiac lesions; however, chemokines that orchestrate their recruitment not clearly defined. Here, we investigated expression chemokine receptors tissue biopsies obtained RHD patients. Our results showed...
Introduction: The most widely used model for predicting mortality in cardiac surgery was recently remodeled, but the doubts regarding its methodology and development have been reported.Objective: aim of this study to assess performance EuroSCORE II predict patients undergoing coronary artery bypass grafts or valve at our institution.Methods: One thousand consecutive operated on surgery, between October 2008 July 2009, were analyzed.The outcome interest in-hospital mortality.Calibration...
Background Few data exist on the degree of interstitial myocardial fibrosis in patients with classical low-flow, low-gradient aortic stenosis (LFLG-AS) and its association left ventricular flow reserve (FR) dobutamine stress echocardiography. This study sought to evaluate diffuse measured by T1 mapping cardiac magnetic resonance technique LFLG-AS without FR. Methods Prospective including 65 consecutive (41 [mean age, 67.1±8.4 years; 83% men] 24 high-gradient used as controls) undergoing...