A5064120463- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immune responses and vaccinations
- COVID-19 epidemiological studies
- Immune Cell Function and Interaction
- COVID-19 and Mental Health
- Periodontal Regeneration and Treatments
- interferon and immune responses
- Mast cells and histamine
- Spine and Intervertebral Disc Pathology
- Assisted Reproductive Technology and Twin Pregnancy
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Plant Virus Research Studies
- Vaccine Coverage and Hesitancy
- Genetics, Aging, and Longevity in Model Organisms
- Dietary Effects on Health
- vaccines and immunoinformatics approaches
- Diabetes and associated disorders
- Sexual function and dysfunction studies
- Cytomegalovirus and herpesvirus research
- Long-Term Effects of COVID-19
- Spinal Cord Injury Research
- Animal Virus Infections Studies
Universidade de São Paulo
2021-2024
Stem Cell Institute
2021
Universidade Estadual de Campinas (UNICAMP)
2019-2020
Despite the high number of individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop disease 2019 (COVID-19) symptoms worldwide, many exposed remain asymptomatic and/or uninfected and seronegative. This could be explained a combination environmental (exposure), immunological (previous infection), epigenetic, genetic factors. Aiming to identify factors involved in immune response symptomatic COVID-19 as compared individuals, we analyzed 83 Brazilian...
ABSTRACT Background Clinical recurrence of COVID-19 in convalescent patients has been reported, which immune mechanisms have not thoroughly investigated. Presence neutralizing antibodies suggests other types response are involved. Methods We assessed the innate type I/III IFN response, T cell responses to SARS-CoV-2 with IFNγ ELISPOT, binding and antibody assays, two monozygotic twin pairs one case. Results In pair 1, four months after a first mild episode infection for both siblings,...
Although aging correlates with a worse prognosis for Covid-19, super elderly still unvaccinated individuals presenting mild or no symptoms have been reported worldwide. Most of the genetic variants responsible increased disease susceptibility are associated immune response, involving type I IFN immunity and modulation; HLA cluster genes; inflammasome activation; genes interleukins; chemokines receptors. On other hand, little is known about resistance mechanisms against SARS-CoV-2 infection....
COVID-19 has affected millions of people worldwide. Clinical manifestations range from severe cases with lethal outcome to mild or asymptomatic cases. Although the proportion infected individuals does not differ between sexes, men are more susceptible COVID-19, a higher risk death than women. Also, pointed out as lax regarding protective measures, mask wearing and vaccination. Thus, we questioned whether sex-bias may be explained by biological pathways and/or behavioral aspects both.Between...
Abstract Background Although older adults are at a high risk of severe or critical Covid-19, there many cases unvaccinated centenarians who had silent infection recovered from mild moderate Covid-19. We studied three Brazilian supercentenarians, than 110 years, survived Covid-19 in 2020 before being vaccinated. Results Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels IgG and neutralizing antibodies (NAbs) against SARS-CoV-2....
Abstract Background Despite the high number of individuals infected by SARS-CoV-2 who develop COVID-19 symptoms worldwide, many exposed remain asymptomatic and/or stay uninfected. This could be explained a combination environmental (exposure, previous infection), epigenetic, and genetic factors. Aiming to identify variants involved in resistance, we analyzed 86 discordant Brazilian couples where one was symptomatic while partner remained seronegative despite sharing same bedroom during...
The COVID-19 pandemic has prompted a quest to understand why certain individuals remain uninfected or asymptomatic despite repetitive exposure SARS-CoV-2. Here, we focused on six exposed females residing with their symptomatic and reinfected SARS-CoV-2 PCR-positive partners. Peripheral blood mononuclear cell samples from couples were analysed for poly (I:C)-induced mRNA expression of type I/III interferons interferon-stimulated genes (ISGs). Remarkably, found significant upregulation the ISG...
Recurrence of COVID-19 in recovered patients has been increasingly reported. However, the immune mechanisms behind recurrence have not thoroughly investigated. The presence neutralizing antibodies (nAbs) recurrence/reinfection cases suggests that other types response are involved protection against recurrence. Here, we investigated innate type I/III interferon (IFN) response, binding and nAb assays T-cell responses to severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) with...
Dorsal root rhizotomy (DRZ) is currently considered an untreatable injury, resulting in the loss of sensitive function and usually leading to neuropathic pain. In this context, we recently proposed a new surgical approach treat DRZ that uses platelet-rich plasma (PRP) gel restore spinal reflex. Success was correlated with reentry primary afferents into cord. Here, aiming enhance previous results, cell therapy bioengineered human embryonic stem cells (hESCs) overexpress fibroblast growth...
Abstract Investigations on the concordance in monozygotic (MZ) as compared to dizygotic (DZ) twins may reveal if there is a genetic component increasing susceptibility or resistance against an infectious disease. Here, we rates of SARS-CoV-2 infection MZ versus DZ young who shared same bedrooms and were equally exposed virus. The rate was higher group supporting complex multifactorial inheritance responsible for SARS-Cov-2 infection.
Background The influence of the host genome on coronavirus disease 2019 (COVID-19) susceptibility and severity is supported by reports monozygotic (MZ) twins where both were infected simultaneously with similar outcomes, including several who died due to SARS-CoV-2 infection within days apart. However, successive exposures pathogens throughout life along other environmental factors make immune response unique for each individual, even among MZ twins. Case presentation methods Here we report...
ABSTRACT Background COVID-19 has affected millions of people worldwide. Clinical manifestations range from severe cases with a lethal outcome to mild or asymptomatic cases. Although there is the same proportion infected genders, men are more susceptible COVID-19, higher risk death than women. This sex-bias may be explained by biological pathways. Methods We performed an epidemiological survey July 2020 2021 including 1744 unvaccinated adult Brazilian couples at least one spouse despite...
ObjectivesThe X-chromosome contains the largest number of immune-related genes, which play a major role in COVID-19 symptomatology and susceptibility. Here, we had unique opportunity to investigate, for first time, outcomes six unvaccinated young Brazilian patients with Turner syndrome (TS; 45, X0), including one case critical illness child aged 10 years, evaluate their immune response according genetic profile.MethodsA serological analysis humoral against SARS-CoV-2, phenotypic...