A5084976335- Trypanosoma species research and implications
- Cardiomyopathy and Myosin Studies
- Research on Leishmaniasis Studies
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Synthesis and Biological Evaluation
- Parasites and Host Interactions
- Coenzyme Q10 studies and effects
- Viral Infections and Immunology Research
- Cardiac Arrhythmias and Treatments
- Biochemical and Molecular Research
- Cardiovascular Syncope and Autonomic Disorders
- Toxin Mechanisms and Immunotoxins
- Mosquito-borne diseases and control
- Science and Education Research
- Cardiovascular Issues in Pregnancy
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Lysosomal Storage Disorders Research
- Insect symbiosis and bacterial influences
- Coronary Artery Anomalies
- Blood Pressure and Hypertension Studies
- Helminth infection and control
- Healthcare Regulation
Hospital do Coração
2015-2024
Fundação Oswaldo Cruz
2002-2022
Sociedad Española de Cardiología
2022
Universidade de São Paulo
2009-2021
Brazilian Academy of Sciences
2018
Universidade Federal de Goiás
2004-2017
Escola Bahiana de Medicina e Saúde Pública
2015
Fortis Healthcare
2004-2015
Hospital São Rafael
2000-2015
Hospital Santa Izabel
2012
We conducted a prospective, multicenter, randomized study involving 2854 patients with Chagas' cardiomyopathy who received benznidazole or placebo for up to 80 days and were followed mean of 5.4 years. The primary outcome in the time-to-event analysis was first event any components composite death, resuscitated cardiac arrest, sustained ventricular tachycardia, insertion pacemaker implantable cardioverter–defibrillator, transplantation, new heart failure, stroke, other thromboembolic event.
Chagas' disease is an important health problem in Latin America, and cardiac involvement associated with substantial morbidity mortality. We developed a model to predict the risk of death patients heart disease.
Chagas disease is a neglected chronic condition with high burden of morbidity and mortality. It has considerable psychological, social, economic impacts. The represents significant public health issue in Brazil, different regional patterns. This document presents the evidence that resulted Brazilian Consensus on Disease. objective was to review standardize strategies for diagnosis, treatment, prevention, control country, based available scientific evidence. consensus articulation strategic...
Chagas disease is a neglected chronic condition that presents high morbidity and mortality burden, with considerable psychological, social, economic impact.The represents significant public health issue in Brazil, different regional patterns.This document the evidence resulted Brazilian Consensus on Disease.The objective was to review standardize strategies for diagnosis, treatment, prevention, control of country, based available scientific evidence.The consensus collaboration contribution...
Chagas heart disease (CHD) results from infection with the protozoan parasite Trypanosoma cruzi and is leading cause of infectious myocarditis worldwide. It poses a substantial public health burden due to high morbidity mortality. CHD also most serious frequent manifestation chronic appears in 20-40% infected individuals between 10-30 years after original acute infection. In recent decades, numerous clinical experimental investigations have shown that low-grade but incessant parasitism,...
Among the pathophysiological derangements operating in chronic phase of Chagas disease, parasite persistence is likely to constitute main mechanism myocardial injury patients with chagasic cardiomyopathy. The presence Trypanosoma cruzi heart causes a low-grade, but relentless, inflammatory process and induces autoimmune injury. These facts suggest that trypanocidal therapy may positively impact clinical course disease. However, experimental evidence currently available insufficient support...
A century after its discovery, Chagas' disease still represents a major public health challenge in Latin America. Moreover, because of growing population movements, an increasing number cases imported have now been detected non-endemic areas, such as North America and some European countries. This parasitic zoonosis, caused by <i>Trypanosoma cruzi</i>, is transmitted to humans infected Triatominae insects, or occasionally non-vectorial mechanisms, blood transfusion, mother fetus, oral...
Background Myocardium damage during Chagas' disease results from the immunological imbalance between pro- and production of anti-inflammatory cytokines has been explained based on Th1–Th2 dichotomy regulatory T cell activity. Recently, we demonstrated that IL-17 produced experimental T. cruzi infection regulates Th1 cells differentiation parasite induced myocarditis. Here, investigated role human disease. Methodology/Principal Findings First, observed CD4+IL-17+ in culture peripheral blood...
Lista de Siglas/Abreviaturas 18 F-FDG – fluordesoxiglicose marcado com flúor-18 123 I-MIBG meta-iodo-benzil-guanidina iodo-123 […] Diretriz da SBC sobre Diagnóstico e Tratamento Pacientes Cardiomiopatia Doença Chagas 2023