A5044352232- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Insect symbiosis and bacterial influences
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- vaccines and immunoinformatics approaches
- Biochemical and Molecular Research
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Parasites and Host Interactions
- Parasitic Diseases Research and Treatment
- Viral Infections and Vectors
- Malaria Research and Control
- Traditional and Medicinal Uses of Annonaceae
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Transgenic Plants and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Cyclopropane Reaction Mechanisms
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Plant Virus Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Venomous Animal Envenomation and Studies
Instituto de Salud Carlos III
2022-2025
Centro de Investigación Biomédica en Red
2022-2025
Barcelona Institute for Global Health
2017-2025
Universitat de Barcelona
2017-2025
Instituto de Investigación de Enfermedades Raras
2024
Centro Nacional de Microbiologia
2022
Hospital Clínic de Barcelona
2017
University of Glasgow
2015-2017
New York University
2014-2015
Centro Nacional de Biotecnología
2012-2013
Abstract Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against three kinetoplastids most relevant to human disease, i.e. Leishmania donovani , Trypanosoma cruzi and brucei . Secondary confirmatory orthogonal intracellular anti-parasiticidal assays were conducted potential for non-specific cytotoxicity determined. Hit chemically clustered triaged desirable physicochemical properties. The hypothetical...
Chagas disease is caused by the parasite Trypanosoma cruzi. It affects several million people, mainly in Latin America, and severe cardiac and/or digestive complications occur ~30% of chronically infected patients. Disease acute stage mostly asymptomatic infection goes undiagnosed. In chronic phase direct detection hampered due to its concealed presence diagnosis achieved serological methods, like ELISA or indirect hemagglutination assays. Agreement at least two tests must be obtained wide...
Trypanosoma cruzi infection causes Chagas disease which affects 7 million people worldwide. Two drugs are available to treat it: benznidazole and nifurtimox. Although both efficacious against the acute stage of disease, this is usually asymptomatic goes undiagnosed untreated. Diagnosis achieved at chronic stage, when life-threatening heart and/or gut tissue disruptions occur in ~30% those chronically infected. By then drugs´ efficacy reduced, but not their associated high toxicity. Given...
There is no consensus on the diagnostic algorithms for many scenarios of Trypanosoma cruzi infection, which hinders establishment governmental guidelines in endemic and non-endemic countries. In acute phase, parasitological methods are currently employed, standardised surrogate molecular tests being introduced to provide higher sensitivity less operator-dependence. chronic IgG-based serological assays used, but if a single assay does not reach required accuracy, PAHO/WHO recommends at least...
West Nile virus (WNV), the most widely distributed flavivirus worldwide, has lately reemerged in Europe, causing worrisome outbreaks humans and horses. Serological analysis by enzyme-linked immunoassay plaque reduction neutralization test showed for first time Serbia that 12% of 349 horses presented specific neutralizing WNV antibodies, which one case also cross-neutralized Usutu (USUV). This is anti-USUV high antibody titers are reported All these data indicate USUV circulating region...
Background Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, represents a very important public health problem in Latin America where it is endemic. Although mostly asymptomatic at its initial stage, after disease becomes chronic, about third of infected patients progress to potentially fatal outcome due severe damage heart and gut tissues. There an urgent need for new drugs against since there are only two available, benznidazole nifurtimox, both show toxic side effects...
ISGlobal work is supported by the Departament d’Universitats i Recerca de la Generalitat Catalunya, Spain (AGAUR; 017SGR00924) and Instituto Salud Carlos III (ISCIII) RICET Network for Cooperative Research in Tropical Diseases (ISCIII; RD16/0027/0004 - PI1290) FEDER. MJP research Ministry of Health, Government Catalonia (PERIS 2016-2010 SLT008/18/00132). ICA, JG, FT are grant number U01AI129783 from National Institute Allergy Infectious (NIAID), Institutes Health (NIH). ICA also partly...
Chagas disease (CD), caused by the protozoan Trypanosoma cruzi (T. cruzi), poses a major health challenge in Paraguay, especially resource-limited Chaco region. Rapid diagnostic tests (RDTs) are valuable tools to enhance access. This study evaluates CD prevalence and risk factors an indigenous community Paraguayan validates national RDT-based algorithm for settings against recommended standard algorithm, which relies solely on conventional serological tests. A descriptive cross-sectional was...
Chagas disease affects 6-7 million people, mainly in the Americas, and benznidazole is one of two therapeutic options available. Trypanocide treatment aims to eliminate parasite from body prevent establishment or progression visceral damage, cardiac and/or digestive. Remarkably, it helps interrupt vertical transmission when administered women childbearing age.We discuss basic scarce data regarding chemical, pharmacokinetic, pharmacodynamic structure. We also collect most important previous...
Abstract Background Chagas disease, caused by the protozoan Trypanosoma cruzi , is a neglected disease that affects ~7 million people worldwide. Development of new drugs to treat infection remains priority since those currently available have frequent side effects and limited efficacy at chronic stage. Natural products provide pool diversity structures lead chemical synthesis novel molecules for this purpose. Herein we analyzed anti- T. activity nine alkaloids derived from plants family...
Background Chagas disease or American trypanosomiasis, a neglected tropical disease, is persistent Public Health problem in Latin America and other, non-endemic, countries. Point-of-care (POC) sensitive methods are still needed to improve extend early diagnosis acute infections such as congenital disease. The objective of this study was analytically evaluate the lab performance qualitative POC molecular test (Loop-mediated isothermal amplification (LAMP), Eiken, Japan) for rapid employing...
Epstein-Barr virus is a very common human that infects 90% of adults. EBV replicates in epithelial and B cells causes infectious mononucleosis. infection also linked to various cancers, including Burkitt’s lymphoma nasopharyngeal carcinomas, autoimmune diseases such as multiple sclerosis. Currently, there are no effective drugs or vaccines treat prevent infection. Herein, we applied computer-aided strategy design prophylactic epitope vaccine ensemble from experimentally defined T cell...
BackgroundVertical transmission of Trypanosoma cruzi represents approximately 20% new Chagas disease cases. Early detection and treatment for women childbearing age newborns is a public health priority, but the lack simple reliable diagnostic test remains major barrier. We aimed to evaluate performance point-of-care loop-mediated isothermal amplification (LAMP) assay T cruzi.MethodsIn this proof-of-concept study, we coupled low-cost 3D printer repurposed sample preparation (PrintrLab) Eiken...
Chagas disease, caused by the parasite Trypanosoma cruzi, is neglected tropical disease with a highest burden in Latin America. Its acute stage mostly asymptomatic and goes unnoticed. Symptoms appear at chronic stage, which when diagnosis usually made. This based on agreement of two conventional serological tests such as Enzyme-Linked Immunosorbent Assays (ELISAs). There are commercial kits good sensitivity specificity but their use impractical many highly endemic regions poorly equipped...