A5086590031- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Parasitic Infections and Diagnostics
- Parasites and Host Interactions
- Cytomegalovirus and herpesvirus research
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Rabies epidemiology and control
- Heme Oxygenase-1 and Carbon Monoxide
- HIV Research and Treatment
- Travel-related health issues
- HIV/AIDS drug development and treatment
- Parasite Biology and Host Interactions
- HIV/AIDS Research and Interventions
- Mosquito-borne diseases and control
- Parasitic infections in humans and animals
- Global Maternal and Child Health
- Malaria Research and Control
- Dermatological diseases and infestations
- Synthesis and Biological Evaluation
- Parasitic Diseases Research and Treatment
- Sex work and related issues
- Viral Infections and Vectors
- Biochemical and Molecular Research
- Eosinophilic Disorders and Syndromes
Hôpital Pellegrin
2025
Médecins du Monde
2025
Hôpital Paul-Brousse
2025
Assistance Publique – Hôpitaux de Paris
2015-2024
Sorbonne Université
2015-2024
Pitié-Salpêtrière Hospital
2013-2024
Hôpitaux Universitaires de Strasbourg
2023-2024
Sorbonne Paris Cité
2023
Université Paris 1 Panthéon-Sorbonne
2023
Hôpital Charles-Foix
2015-2020
To study the influence of Toxoplasma gondii genotypes on severity human congenital toxoplasmosis (asymptomatic, benign, or severe infection newborn fetal death), 8 microsatellite markers were used to analyze 86 T. isolates collected from patients with toxoplasmosis. Seventy-four different detected, some identical originating probably same source contamination. The 3 less polymorphic associated 6 isoenzymatic allowed a classification into classical types and detected atypical genotypes....
Women infected with toxoplasmosis during pregnancy do not present symptoms in most cases, but the consequences of congenital infection may be severe for unborn child. Fetal damage can range from asymptomatic to neurological alterations retinal lesions prone potential flare up and relapses lifelong. Despite possible severity outcome, (CT) is a neglected disease. There no consensus regarding screening pregnancy, prenatal/postnatal treatment or short medium term follow-up. Since 1992, France...
We report the genotyping analysis of Toxoplasma gondii isolates in samples collected from 88 immunocompromised patients, along with clinical and epidemiological data. Most these were France during current decade by Biological Resource Center. Lack specific anti-Toxoplasma treatment, pulmonary toxoplasmosis, involvement multiple organs 3 main risk factors associated death for this patient group. Genotyping results 6 microsatellite markers showed that type II predominant among patients who...
ABSTRACT We compared three biological methods for the diagnosis of ocular toxoplasmosis (OT). Paired aqueous humor and serum samples from 34 patients with OT 76 other disorders were analyzed by methods: immunoblotting or Western blotting (WB), calculation Goldmann-Witmer coefficient (GWC), PCR. WB GWC each revealed intraocular production specific anti- Toxoplasma immunoglobulin G in 81% (30 37). PCR detected toxoplasmic DNA 38% (13 34). Nine 13 PCR-positive immunocompetent. Combining...
Eosinophilic-related clinical manifestations are protean and the underlying conditions underpinning eosinophilia highly diverse. The etiological workup of unexplained eosinophilia/hypereosinophilia can be challenging, lead sometimes to extensive, inappropriate, costly and/or invasive investigations. To date, guidelines for management mainly issued by hematologists, thus mostly cover scope clonal hypereosinophilic syndromes (HES). Here, thanks an extensive literature review, joint work a...
Chagas disease is one of the main public health issues in Latin America. Increasingly during past few decades, Trypanosoma cruzi infection has been detected North America, Europe, and Western Pacific, mainly as a result population movement. The limited availability rapid serological diagnostic tests hinders diagnosis early treatment areas endemicity nonendemicity. In collaboration with 11 national reference laboratories (NRLs) from different geographical areas, we evaluated performances...
Classically, Toxoplasma infection is associated with high levels of specific IgM antibody and a rise in IgG 1 to 3 weeks later. Atypical seroconversion, without detection or transient levels, has been described during serologic follow-up seronegative pregnant women raises difficulties interpreting the results. To evaluate frequency characteristics these atypical cases an investigation was conducted within French National Reference Center for Toxoplasmosis, from which 26 collected 12...
Neurocysticercosis (NC), caused by the larval stage of Taenia solium, is one most common parasitic diseases central nervous system. The diagnosis NC mostly based on costly brain neuroimaging (computed tomography and/or nuclear magnetic resonance), which rarely accessible in affected areas. sensitive and specific tools for are imagery techniques. identification antibodies antigens currently used only to support due their limited specificity sensitivity. This study was performed compare...
ABSTRACT We report the direct genotyping analysis of Toxoplasma gondii in ocular samples collected from 20 patients, as well associated clinical and epidemiological data. This work was aimed at better understanding impact genotypes strains on toxoplasmic retinochoroiditis. For this purpose, we studied aqueous humor (AH) or vitreous (VH) patients presenting with toxoplasmosis (OT) 2 hospitals France. Genetic characterization obtained microsatellite markers a multiplex PCR assay. In contrast...
Toxoplasma infection in pregnant women may cause congenital toxoplasmosis. Diagnosis of is based on serological tests aimed at detecting IgM and IgG antibodies against gondii. However, are not an accurate marker for discriminating between acute latent infection. Detection residual or persistent occur months even years after primary infection, while the avidity test a rapid means identifying infections who exhibit both anti-Toxoplasma initial testing during pregnancy. In this study, we...
PCR detection of Toxoplasma gondii in blood has been suggested as a possibly efficient method for the diagnosis ocular toxoplasmosis (OT) and furthermore genotyping strain involved disease. To assess this hypothesis, we performed with 121 peripheral samples from 104 patients showing clinical and/or biological evidence 284 (258 patients) controls. We tested 2 different extraction protocols, using either 200 μl (small volume) or ml (large whole blood. Sensitivity was poor, i.e., 4.1% 25%...
Worldwide, amoebic liver abscess (ALA) can be found in individuals non-endemic areas, especially foreign-born travelers.We performed a retrospective analysis of ALA patients admitted to French hospitals between 2002 and 2006. We compared imported cases European assessed the factors associated with size using logistic regression model.We investigated 90 cases. Patient median age was 41. The male:female ratio 3.5:1. were able determine origin for 75 patients: 38 European-born 37 foreign-born....
Chagas disease is a debilitating often fatal resulting from infection by the protozoan parasite Trypanosoma cruzi. endemic in 21 countries of Americas, and it an emerging other as result migration. Given chronic nature where intracellular parasites persist for years, diagnosis T. cruzi direct detection difficult, whereas serologic tests though sensitive may yield false-positive results. The development new rapid test based on identification soluble parasitic antigens serum would be real...
We read with great interest the recent paper from Martín-Carmona et al., who found that HIV does not increase mortality risk after hepatitis C virus (HCV) cure direct-acting antivirals (DAA) in people advanced liver fibrosis [1].By publishing long-term followup data, authors provide valuable insights into unresolved question of whether or increases HCV cure.
Objectives To evaluate the benefits of therapeutic drug monitoring (TDM) in association with genotypic resistance testing and expert advice to optimize therapy multiexperienced patients infected HIV‐1. Methods Patients a viral load>1000 HIV‐1 RNA copies/mL an unchanged antiretroviral regimen over last 3 months were randomized into two groups: group (G) geno‐pharmacological (GP). Treatment was selected by committee according (the G GP groups) TDM group) at week 4. could be modified each...
Creeping eruption is a migratory linear cutaneous trail. In addition to hookworm-related larva migrans (HrCLM), other diseases can also be revealed by this sign.To report the different aetiologies of creeping eruption.All consecutive patients with presenting our unit in Pitié Salpêtrière Hospital Paris between 1 March 2008 and 31 January 2013 were included. The diagnoses based on microscopic data when available (hookworm folliculitis, strongyloidiasis) or association epidemiological,...
ABSTRACT We report a case of Guillain-Barré syndrome associated with an acute, disseminated toxoplasmosis due to new and unknown zymodeme (zymodeme 12) in immunocompetent patient. The patient’s condition improved pyrimethamine sulfadiazine. Only the standard treatment for was effective, whereas intravenous immunoglobulins were ineffective.
Chagas disease is endemic in Latin America (LA). Currently 10 million people are infected despite World Health Organization efforts aimed at preventing domestic transmission. However, with the migration of asymptomatic individuals to nonendemic countries, transmission by transfusion may become a worldwide problem. The observation that number cases has increased over past years French Guiana, together results previous hospital-based study Paris area, confirms from patients coming LA. For...