A5035251373- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Genomics and Phylogenetic Studies
- Asthma and respiratory diseases
- Parasitic infections in humans and animals
- Vector-Borne Animal Diseases
- Infectious Diseases and Tuberculosis
- Leprosy Research and Treatment
- Microbial infections and disease research
- Insect and Pesticide Research
- Bartonella species infections research
- Parasitic Infections and Diagnostics
- Insect symbiosis and bacterial influences
- Antibiotic Resistance in Bacteria
- Congenital Anomalies and Fetal Surgery
- Infectious Diseases and Mycology
- Inhalation and Respiratory Drug Delivery
- Parasite Biology and Host Interactions
- Respiratory and Cough-Related Research
- Amphibian and Reptile Biology
- Occupational exposure and asthma
- Genetic and phenotypic traits in livestock
Paris-Est Sup
2021-2024
Département Santé Animale
2013-2024
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2013-2023
Advanced Network and Services (United States)
2022
Centre de Recerca en Sanitat Animal
2019
Government of Catalonia
2019
École Nationale Vétérinaire d'Alfort
2013-2018
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2013-2018
Agence Nationale des Fréquences
2018
Infectiologie Animale et Santé Publique
2018
Due to increased travel, climatic, and environmental changes, the incidence of tick-borne disease in both humans animals is increasing throughout Europe. Therefore, extended surveillance tools are desirable. To accurately screen pathogens, a large scale epidemiological study was conducted on 7050 Ixodes ricinus nymphs collected from France, Denmark, Netherlands using powerful new high-throughput approach. This advanced methodology permitted simultaneous detection 25 bacterial, 12 parasitic...
Introduction Ticks are the most common arthropod vectors of both human and animal diseases in Europe, Ixodes ricinus tick species is able to transmit a large number bacteria, viruses parasites. may also be co-infected with several pathogens, subsequent high likelihood co-transmission humans or animals. However few data exist regarding co-infection prevalences, these studies only focus on certain well-known pathogens. In addition ticks carry symbionts that play important roles biology, could...
Ticks are highly susceptible to global environmental and socio-economical changes. Several tick-borne pathogens have been reported in new geographical regions while species, strains or genetic variants of microorganisms continually being detected. However, still poorly understood, it is estimated that half all human disease has an unknown origin. Therefore order prevent these diseases, more effort required identify unexpected pathogens. Ixodes ricinus the vector for a broad range bacterial...
In France as elsewhere in Europe the most prevalent TBD humans is Lyme borreliosis, caused by different bacterial species belonging to Borrelia burgdorferi sensu lato complex and transmitted important tick France, Ixodes ricinus. However, diagnosis of disease not always confirmed unexplained syndromes occurring after bites have become an issue. Recently, B. miyamotoi relapsing fever group same has been involved human Russia, USA Netherlands. present study, we investigate presence along with...
Neurocysticercosis (NC), caused by the larval stage of Taenia solium, is one most common parasitic diseases central nervous system. The diagnosis NC mostly based on costly brain neuroimaging (computed tomography and/or nuclear magnetic resonance), which rarely accessible in affected areas. sensitive and specific tools for are imagery techniques. identification antibodies antigens currently used only to support due their limited specificity sensitivity. This study was performed compare...
Worldwide, ticks transmit more pathogens than other arthropods. Around 60 bacteria, 30 parasites and 100 viruses have been registered as tick-borne pathogens; a third of these are responsible for zoonoses. Usually, detection depends on the tick species collected: assays performed restricted number that known to be transmitted by particular collected at site. To better understand epidemiology pathogens, it will important detect each sample (one or one pool ticks) most diseases they...
Background Risk assessment of tick-borne and zoonotic disease emergence necessitates sound knowledge the particular microorganisms circulating within communities these major vectors. Assessment pathogens carried by wild ticks must be performed without a priori, to allow for detection new or unexpected agents. Methodology/Principal Findings We evaluated potential Next-Generation Sequencing techniques (NGS) produce an inventory parasites questing ticks. Sequences corresponding from two...
In recent years the diversity of French Mycobacterium bovis population responsible for bovine tuberculosis (bTB) outbreaks since 1970 has been described in detail. To further understand bTB evolution France, we used single nucleotide polymorphisms (SNPs) based on whole genome sequence versus classical genotyping methods order to identify accurate phylogenetic relationships between M. strains. Whole sequencing was carried out a selection 87 strains which reflect population's genetic...
Ticks are one of the principal arthropod vectors human and animal infectious diseases. Whereas prevalence tick-borne encephalitis virus in ticks Europe is well studied, there less information available on other viruses (TBVs) existing worldwide. The aim this study was to improve epidemiological survey tools TBVs by development an efficient high-throughput test screen a wide range ticks. In study, we developed new virus-detection assay based parallel real-time PCRs microfluidic system, used...
Abstract The single and comparative intradermal tuberculin tests (SITT CITT) are official in vivo for bovine tuberculosis (TB) diagnosis using avian purified protein derivatives (PPD-B PPD-A). Infection with bacteria other than Mycobacterium complex (MTC) can result nonspecific reactions to these tests. We evaluated the performance of skin test PPDs new defined antigens guinea pig model. A standard dose (SD) Rhodococcus equi , Nocardia sp., M . nonchromogenicum monacense intracellulare avium...
In France, animal tuberculosis (TB) due to Mycobacterium bovis (M. bovis) affects a multi-host community that include cattle and wildlife species such as wild boars (Sus scrofa), badgers (Meles meles), or deer (Cervus elaphus, Capreolus capreolus). The involvement of foxes in the epidemiology TB is fairly described countries facing multispecies concerns. After discovery grouped cases French endemic region, study was implemented core four areas Dordogne, Charente, Landes (departments...
Abstract In two “départements” in the South-West of France, bovine tuberculosis (bTB) outbreaks due to Mycobacterium bovis spoligotype SB0821 have been identified cattle since 2002 and wildlife 2013. Using whole genome sequencing, aim our study was clarify badger contribution bTB transmission this area. We used a Bayesian evolutionary model, infer phylogenetic trees migration rates between pathogen populations defined by their host-species. order account for sampling bias, sub-population...
We describe here 35 animal cases of tuberculosis due to Mycobacterium microti in France (2002-2014). Recently, molecular tools that overcome the difficulty confirming infection by this potentially zoonotic agent have revealed an increasing number cases, suggesting its prevalence may been underestimated.
Surveillance of bovine tuberculosis (bTB) is partly based on the sanitary inspection carcasses at abattoir to detect bTB-like lesions which, in compliance with EU recommendations, are analysed by bacteriology and histopathology disclose Mycobacterium bovis (or M. caprae) infection. Moreover, since 2012, a PCR method similar sensitivity specificity values respectively additionally employed France, partially compensating for weaknesses classical diagnostic methods. We collection from cattle...
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Abstract Bovine tuberculosis is a common disease affecting cattle and wildlife worldwide. Mycobacterium bovis circulation in decreases the efficacy of surveillance control programs cattle. Strains European 3 clonal complex are most frequent France. The aim our work was hence to investigate role played by species two M. strains circulation. WGS collected between 2010 2017 distinct areas (Nouvelle‐Aquitaine region, NAq, Côte‐d'Or département, CdO), from badgers, wild boars, were used an...
Nodular thelitis is a chronic enzootic infection affecting dairy cows and goats. The causative agent was recently shown to be related the leprosy-causing bacilli Mycobacterium leprae lepromatosis In this study, genome of pathogen sequenced analyzed. Phylogenomic analyses confirmed that present in nodular tuberculoid scrotitis distinct species leprosy haemophilum Because originally isolated from bovine udder, it named "Mycobacterium uberis" "M. only 3.12 Mb length, which represents smallest...