A5008917230- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Ginseng Biological Effects and Applications
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Infectious Diseases and Mycology
- Pharmacological Effects of Natural Compounds
- Microbial infections and disease research
- Diagnosis and treatment of tuberculosis
- Salmonella and Campylobacter epidemiology
- Fungal Biology and Applications
- Antibiotic Resistance in Bacteria
- Animal Genetics and Reproduction
- Bacterial Genetics and Biotechnology
- Escherichia coli research studies
- Colorectal Cancer Treatments and Studies
- Quinazolinone synthesis and applications
- Cancer Research and Treatments
- Gene expression and cancer classification
- Plant Pathogenic Bacteria Studies
- Pneumonia and Respiratory Infections
- melanin and skin pigmentation
- Microbial Metabolism and Applications
- Probiotics and Fermented Foods
- Legionella and Acanthamoeba research
Université de Tours
2016-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
Infectiologie Animale et Santé Publique
2014-2023
Institut National de la Recherche Agronomique
2015
Centre Val de Loire
2015
Centre Hospitalier Universitaire de Nantes
2013
Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères
1992
Understanding the molecular evolutionary history of organisms usually requires visual comparison genomic regions from related species or strains. Although several applications already exist to achieve this task, they are either too old, limited, complex for most user's needs.
Mycobacterium avium subsp. paratuberculosis is responsible for in animals. This disease, leading to an inflammation of the gastrointestinal tract, has a high impact on animal health and important economic burden. The environmental life cycle poorly understood several studies suggest that free-living amoebae might be potential host. Free-living are protozoa found water soil described as reservoirs pathogenic bacteria environment. Indeed, able survive within these would phagocytosis from...
In recent years the diversity of French Mycobacterium bovis population responsible for bovine tuberculosis (bTB) outbreaks since 1970 has been described in detail. To further understand bTB evolution France, we used single nucleotide polymorphisms (SNPs) based on whole genome sequence versus classical genotyping methods order to identify accurate phylogenetic relationships between M. strains. Whole sequencing was carried out a selection 87 strains which reflect population's genetic...
Mycobacterium avium comprises four subspecies that contain both human and veterinary pathogens. At the inception of this study, twenty-eight M. genomes had been annotated as RefSeq genomes, facilitating direct comparisons. These represent strains from around world provided a unique opportunity to examine genome dynamics in species. Each was confirmed be classified correctly based on SNP genotyping, nucleotide identity presence/absence repetitive elements or other typing methods. The...
Mycobacterium avium subsp. paratuberculosis ( Map ) is the etiological agent of Johne’s disease in ruminants. The IS 900 insertion sequence (IS) has been used widely as an epidemiological marker and target for PCR diagnosis. Updated DNA sequencing technologies have led to a rapid increase available genomes, which makes it possible analyze distribution this slow-growing bacterium. objective study characterize element how affects genomic evolution gene function . A secondary goal develop...
Mycobacteria have a complex cell wall structure that includes many lipids; however, even within single subspecies of Mycobacterium avium these lipids can differ. Total from an M. subsp. paratuberculosis (Map) ovine strain (S-type) contained no identifiable glycopeptidolipids or lipopentapeptide (L5P), yet both are present in other subspecies. We determined the genetic and phenotypic basis for this difference using sequence analysis as well biochemical physico-chemical approaches. This...
Salmonella enterica is an important foodborne pathogen. Here, we present the construction and characterization of a high-density transposon sequencing library Typhimurium ATCC 14028 strain. Essential, advantageous, disadvantageous genes for growth in rich culture medium were identified on chromosome pSLT plasmid.
Unlike other MAC members, Mycobacterium avium subsp. paratuberculosis (MAP) does not produce glycopeptidolipids (GPL) on the surface of cell wall but a lipopentapeptide called L5P (also termed Lipopeptide-I or Para-LP-01) characterized in C-type (bovine) strains. This lipopeptide antigen contains pentapeptide core, D-Phenylalanine-N-methyl-L-Valine-L-Isoleucine-L-Phenylalanine-L-Alanine, which N-terminal D-Phenylalanine is amido-linked with fatty acid (C18-C20). The molecular and genetic...
Escherichia coli is a very versatile species for which diversity has been explored from various perspectives highlighting, example, phylogenetic groupings and pathovars, as well wide range of O serotypes. The highly variable O-antigen, the most external part lipopolysaccharide (LPS) component outer membrane E. , linked to innermost lipid A through core region LPS five different structures, denominated K-12, R1, R2, R3 R4, have characterized so far. aim present study was analyse prevalence...
Bovine tuberculosis (TB) is a zoonotic disease, mainly caused by Mycobacterium bovis. France was declared officially TB free in 2001, however, the disease persists livestock and wildlife. Among wild animals, deer are particularly susceptible to bovine TB. Here, whole genome sequence (WGS) analysis performed on strains with same genetic profile—spoligotype SB0121, Multiple Loci VNTR Analysis (MLVA) 6 4 5 3 11 2 7—isolated from different types of outbreaks, including or cattle herds,...
Mycobacterium bovis is the etiologic agent of bovine tuberculosis, a chronic infectious disease, affecting livestock, wild animals, and sometimes humans. We report draft genome sequence strain isolated from boar spoligotype SB0120 (or BCG-like) also present in wildlife-livestock multi-host systems.
Streptococcus agalactiae is a major pathogen and the leading cause of neonatal infections in industrialized countries. The diversity strains isolated from two pregnant women was investigated. Here, we present draft genome sequences W8A2, W8A6, W10E2, W10F3, obtained order to ascertain their phylogenetic affiliation.
Mycobacterium avium subsp. paratuberculosis is the etiological agent of Johne’s disease in ruminants. Here, we report annotated draft genome sequences 142 M. strains that were isolated from dairy cattle France between 2014 and 2018. The genomes these sequenced using Illumina technology.
The Mycobacterium avium complex includes two closely related species, and intracellulare. They are opportunistic pathogens in humans responsible for severe disease a wide variety of animals. Yet, little is known about factors involved their pathogenicity. Here, we identified, purified characterized adhesins belonging to the heparin-binding hemagglutinin (HBHA) laminin-binding protein (LBP) family from M. intracellulare ATCC13950 examined clinical isolates patients with different pathologies...
Mycobacterium bovis is the etiologic agent of bovine tuberculosis, a chronic infectious disease affecting livestock, wild animals, and sometimes humans. We report here three draft genome sequences strains spoligotypes SB0821 SB0134, isolated from wildlife but circulating in wildlife-livestock multihost systems, SB0121, exclusively cattle.