A5016210934- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Parasitic Infections and Diagnostics
- Trypanosoma species research and implications
- Fungal Infections and Studies
- Parvovirus B19 Infection Studies
- Streptococcal Infections and Treatments
- Travel-related health issues
- Antifungal resistance and susceptibility
- Syphilis Diagnosis and Treatment
- Immune Response and Inflammation
- Hearing, Cochlea, Tinnitus, Genetics
- T-cell and Retrovirus Studies
- Nail Diseases and Treatments
- Sex work and related issues
- Health, Education, and Cultural Studies
- Neonatal Health and Biochemistry
- Rabies epidemiology and control
- interferon and immune responses
- Ophthalmology and Visual Health Research
- Retinopathy of Prematurity Studies
- Retinal and Optic Conditions
- Spectroscopy Techniques in Biomedical and Chemical Research
- Infectious Encephalopathies and Encephalitis
Universidade Federal de Minas Gerais
2011-2024
Hospital das Clínicas da Universidade Federal de Minas Gerais
2006-2021
Centro Universitário de Belo Horizonte
2019
Companhia Energética de Minas Gerais (Brazil)
2019
Prefeitura Municipal de Belo Horizonte
2006-2017
Chagas disease is a neglected chronic condition with high burden of morbidity and mortality. It has considerable psychological, social, economic impacts. The represents significant public health issue in Brazil, different regional patterns. This document presents the evidence that resulted Brazilian Consensus on Disease. objective was to review standardize strategies for diagnosis, treatment, prevention, control country, based available scientific evidence. consensus articulation strategic...
Chagas disease is a neglected chronic condition that presents high morbidity and mortality burden, with considerable psychological, social, economic impact.The represents significant public health issue in Brazil, different regional patterns.This document the evidence resulted Brazilian Consensus on Disease.The objective was to review standardize strategies for diagnosis, treatment, prevention, control of country, based available scientific evidence.The consensus collaboration contribution...
ABSTRACT Recent studies of Toxoplasma gondii isolates from animals in Brazil have revealed high genetic diversity. Many these are virulent to mice. It is speculated that may also be humans. However, there very limited data regarding T. strains human infection. Therefore, it not clear whether any association between parasite genotypes and disease phenotypes. In this study, a total 27 were isolated humans with congenital toxoplasmosis Minas Gerais state, Brazil. The variability was assessed by...
Toxoplasma gondii is the main infectious cause of human posterior retinochoroiditis, most frequent clinical manifestation congenital toxoplasmosis. This investigation was performed after neonatal screening to identify biomarkers immunity associated with immunopathological features disease by flow cytometry. The study included infected infants without NRL and retinochoroidal lesions (ARL, ACRL, CRL) as well noninfected individuals (NI). Our data demonstrated that leukocytosis, increased...
A diverse group of professionals gathered in Brasília for the VI Brazilian Symposium on Toxoplasmosis and III International from October 17 to 19, 2023. Guided by ‘One Health’ concept, event addressed toxoplasmosis its human, animal, environmental dimensions. Participants discussed strategies improve prevention, diagnosis, treatment disease Brazil, also emphasizing a Pan-American cooperation. The resulting document, Letter: Proposal Control Brazil with Multidisciplinary Approach Cooperation...
Objective Congenital toxoplasmosis is a public health problem in Brazil. This study aimed to determine risk factors associated with congenital Minas Gerais which the second largest Brazilian State based on number of inhabitants, and its territorial extension larger than that France. Methods: Population-based case-control assess association between maternal exposure infection factors. The included mothers/children participating Newborn Screening Program. cases consisted 175 mothers infected...
The purpose of this study was to develop novel hybrid organic–inorganic materials based on poly(vinyl alcohol) (PVA) polymer chemically crosslinked network be tested as solid support bovine herpesvirus immunoassay. Hybrids were synthesized by reacting PVA with three different alkoxysilanes modifying chemical groups: tetraethoxysilane (TEOS), 3-mercaptopropyltrimethoxysilane (MPTMS) and 3-glycidoxypropyltrimethoxysilane (GPTMS). PVA-derived hybrids also modified crosslinking glutaraldehyde...
OBJETIVO: Apresentar um caso raro de toxoplasmose congênita uma mãe imunocompetente com infecção crônica que teve reativação da doença ocular durante a gestação. DESCRIÇÃO: O recém-nascido estava assintomático no nascimento e foi identificado através triagem neonatal (IgM anti-Toxoplasma gondii em sangue seco) entre outros 190 bebês período 7 meses. Sua tinha tido episódio não tratado retinocoroidite toxoplásmica gestação, títulos IgG estáveis resultados negativos para IgM. Os IgM soro do o...
Abstract In the present study we have evaluated performance of several immunological biomarkers for early diagnosis and prognosis congenital toxoplasmosis. Our results showed that ex vivo serum levels CXCL9, frequencies circulating CD4 + CD25 T-cells T. gondii -specific IFN-γ measured 30–45 days after birth presented high accuracy to distinguish -infected infants from healthy age-matched controls (Global Accuracy/AUC = 0.9; 0.9 0.8, respectively). Of note was enhanced (Accuracy 96%) achieved...
Foi realizado estudo transversal, em duas maternidades públicas de Belo Horizonte, Minas Gerais, Brasil, com entrevista 420 puérperas, agosto 2004 a maio 2005, para avaliar aplicação do protocolo triagem pré-natal toxoplasmose implantado, e as orientações oferecidas às gestantes suscetíveis. A cobertura foi 98%, da primeira sorológica 97%. O início realização sorologia ocorreram média 16 semanas. Foram identificadas 163 suscetíveis à toxoplasmose: 44% não repetiram sorologia, 42% alegaram...
A toxoplasmose congênita pode causar déficit neurossensorial em até 20% dos casos e o tratamento no primeiro ano de vida melhora prognóstico. No Brasil, desconhece-se impacto da infecção na hipoacusia. OBJETIVO: Avaliar a audição crianças com identificadas pela triagem neonatal. MATERIAL E MÉTODO: Estudo prospectivo neonatal (IgM anti-T. gondii) Belo Horizonte, durante 2003/2004. Realizada sorologia confirmatória (mãe/filho) consideradas positivas as apresentando IgM e/ou IgA nos primeiros...
Congenital toxoplasmosis may cause sensorineural deficit in up to 20% of the patients and proper treatment first year improves prognosis. In Brazil, this infections impact on hearing impairment is unknown.
Real-time PCR (qPCR) was positive in 72/150 (48%) blood samples of newborns with congenital toxoplasmosis. Among infants active retinochoroiditis, 68% had qPCR results, while positivity 29% (P=0.009) the absence ocular involvement. Positive associated presence retinochoroidal lesions, an odds ratio 2.8.
Background. Ocular toxoplasmosis is a prominent and severe condition of high incidence in Brazil. The current study provides new insights into the immunological events that can be associated with retinochoroiditis setting congenital human infants. Methods. Flow cytometry intracytoplasmic cytokines leukocyte subsets following vitro short-term antigenic recall infants T. gondii infection. Results. Our data demonstrates whereas neutrophils monocytes from –infected display combination...
There are few studies reporting frequency and control of adverse events associated with congenital toxoplasmosis treatment. The objective this study is to describe treatment adherence hematologic in a cohort children identified Minas Gerais, Brazil.Children were treated sulfadiazine, pyrimethamine folinic acid evaluated clinically by laboratory tests at regular intervals.Of 146,307 live newborns who participated the Neonatal Screening Program Gerais 2006-2007, 190 had toxoplasmosis. Among...
Cytomegalovirus (CMV) infection is the most common congenital infection, affecting 0.4% to 2.3% newborns. Most of them are asymptomatic at birth, but later 10% develop handicaps, mainly neurological disturbances. Our aim was determine prevalence CMV shed in urine newborns from a neonatal intensive care unit using polymerase chain reaction (PCR) and correlate positive cases some perinatal aspects. Urine samples obtained first week life were processed according PCR protocol. Perinatal data...
Estudo de 38 crianças com paracoccidioidomicose, até 14 anos idade, tratados por 24-30 meses, um derivado sulfamídico ou cetoconazol, desde o início do tratamento em seguida ao uso da anfotericina B. Dados laboratoriais à admissão foram analisados e comparados exames seqüenciais 30 meses acompanhamento. Anemia, eosinofilia bilirrubinas aminotransferases elevadas normalizaram-se, na maioria, os três e, hipoalbuminemia, seis sugerindo que esses achados sejam bons parâmetros para monitoramento...
Congenital toxoplasmosis is an infectious disease with high prevalence in tropical countries. It characterized by neurological, ophthalmological and auditory sequelae. The aim of this study was to evaluate describe the brainstem evoked potential infants aged 1–3 months diagnosed congenital compare them same age group without infection. This observational, analytical cross-sectional which investigated toxoplasmosis. following audiological exams were performed: transient-evoked otoacoustic...