A5045038432- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Transplantation: Methods and Outcomes
- Renal and Vascular Pathologies
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Regulation
- Acute Kidney Injury Research
- Cardiovascular Health and Disease Prevention
- Public Health in Brazil
- Organ Transplantation Techniques and Outcomes
- Hemodynamic Monitoring and Therapy
- Erythropoietin and Anemia Treatment
- Aortic aneurysm repair treatments
- Healthcare during COVID-19 Pandemic
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Parathyroid Disorders and Treatments
- Potassium and Related Disorders
- Diabetes Treatment and Management
- Mechanical Circulatory Support Devices
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2014-2024
Instituto do Coração
2009-2024
Universidade de São Paulo
2007-2024
Hospital do Rim e Hipertensão
2024
Universidade Brasil
2024
Agostinho Neto University
2016-2017
University of Calgary
2016
National Heart Institute
2007-2010
Sociedade Brasileira de Cardiologia
2007
Associação Fundo de Incentivo à Pesquisa
2006
Guidelines for the detection of coronary artery disease (CAD) and assess risk in renal transplant candidates are based on results noninvasive testing, according to data originated nonuremic population. We evaluated prospectively accuracy 2 tests stratification detecting CAD (≥70% obstruction) assessing cardiac by using angiography (CA). One hundred twenty-six who were classified as at moderate (≥50 years) or high (diabetes, extracardiac atherosclerosis, clinical disease) underwent myocardial...
Background Renal transplant candidates are at an increased risk for coronary artery disease (CAD), a strong predictor of cardiovascular events [major adverse (MACE)]. Coronary angiography is costly, risky, invasive procedure. We sought to determine clinical predictors significant CAD (stenosis ≥70%) in high-risk renal candidates. Methods Clinical evaluation and were performed 301 patients (57±8 years, 73% men) on hemodialysis 32 months (median). Patients followed-up 22 Inclusion criteria...
The value of coronary artery disease (CAD) assessment and intervention in the prognosis patients who undergo renal transplantation is controversial. We investigated whether pretransplant identification with CAD helpful for defining preemptive reduces incidence cardiovascular events death after engraftment.We analyzed impact by clinical stratification angiography on 535 chronic kidney waiting list underwent transplantation.Patients 70% or greater narrowing experienced more than less...
In hemodialysis patients, large arteriovenous (AV) fistulas for vascular access may cause ventricular hypertrophy and high-output cardiac failure. The long-term consequences of functional AV in renal transplant patients are unclear. A precise knowledge these is important to decide if when such should be closed successfully transplanted patients. this retrospective study including 61 stable with adequate function (serum creatinine <2.0 mg/100 ml), echocardiography was performed 39 a...
Background. The aim of this study was to examine prospectively the impact renal transplantation on morphological and functional characteristics carotid arteries heart in a group end‐stage failure patients without overt cardiovascular disease, followed up for >3 years.
Chronic kidney disease (CKD) is characterized by the high prevalence of atherosclerosis. Considering that endothelial dysfunction and oxidative stress are promoters atherosclerosis, it interest to verify whether two conditions associated in CKD patients still free clinical cardiovascular (CVD).To evaluate association between function end-stage without clinically evident CVD.We studied 22 nondiabetic, nonsmoker CVD treated maintenance hemodialysis healthy controls. Endothelium- dependent...
Background: The recording of arrhythmic events (AE) in renal transplant candidates (RTCs) undergoing dialysis is limited by conventional electrocardiography.However, continuous cardiac rhythm monitoring seems to be more appropriate due automatic detection arrhythmia, but this method has not been used. Objective: We aimed investigate the incidence and predictors AE RTCs using an implantable loop recorder (ILR).Methods: A prospective observational study conducted from June 2009 January 2011...
In renal transplant candidates (RTC), diabetes and coronary artery disease (CAD) are commonly observed. However, whether imparts a cardiovascular risk equivalent to that of CAD adds the associated with is unknown.To assess interplay between as determinant major adverse events (MACE), 288 high-risk RTC (56.4+/-8.1 years old, 72% males) underwent comprehensive evaluation including angiography. Patients were divided into four groups based on diagnoses (>70% narrowing), followed up for 1-60...
The usefulness of stress myocardial perfusion scintigraphy for cardiovascular (CV) risk stratification in chronic kidney disease remains controversial. We tested the hypothesis that different clinical profiles influence test.We assessed prognostic value 892 consecutive renal transplant candidates classified into four groups: very high (aged≥50 years, diabetes and CV disease), (two factors), intermediate (one factor) low (no factor).The incidence events death was 20 18%, respectively (median...
We assessed the results of a noninvasive therapeutic strategy on long-term occurrence cardiac events and death in registry patients with chronic kidney disease (CKD) coronary artery (CAD).We analyzed 519 CKD (56+/-9 years, 67% men, whites) maintenance hemodialysis clinical or scintigraphic evidence CAD by using angiography.In 230 (44%) patients, angiography revealed significant (lumen reduction > =70%). Subjects were kept medical treatment (MT; n=184) referred for myocardial...
Left ventricular diastolic dysfunction (LVDD) and LV systolic (LVSD) are prevalent in CKD, but their prognostic relevance is debatable. We intent to verify whether LVDD LVSD independently predictive of all-cause mortality if they have comparable or different effects on outcomes.A retrospective analysis was conducted the echocardiographic data 1285 haemodialysis patients followed up until death transplantation. classified into 4 grades severity. Endpoint mortality.During a follow-up 30...
The purposes of this study were to use the myocardial delayed enhancement technique cardiac MRI investigate frequency unrecognized infarction (MI) in patients with end-stage renal disease, compare findings those ECG and SPECT, examine factors that may influence utility these methods detection MI.We prospectively performed MRI, ECG, SPECT detect MI 72 disease at high risk coronary artery but without a clinical history MI.Fifty-six (78%) men (mean age, 56.2 +/- 9.4 years) 16 (22%) women 55.8...
Patients with end-stage renal disease (ESRD) are at high risk for cardiovascular (CVD) and therefore should be treated according to ACC/AHA Guidelines. Scant data available concerning the actual use of cardioprotective drugs in this population. The angiotensin-converting enzyme inhibitors (ACE-I), beta-blockers, aspirin, statins was assessed 271 (72% males, 66% Caucasians) high-risk ESRD patients on hemodialysis. study population comprised 27% smokers, 95% hypertension, 38% diabetes, 44%...
Renal transplant candidates are at high risk of coronary artery disease (CAD). We sought to develop a new score model determine the pre-test probability occurrence significant CAD in renal candidates.A total 1,060 underwent comprehensive cardiovascular evaluation. Patients considered (age ≥50 years, with either diabetes mellitus (DM) or (CVD)), having noninvasive testing suggestive were referred for angiography (n = 524). Significant was defined by presence luminal stenosis ≥70%. A binary...
Abstract We investigated the relationship between blood pressure and occurrence of complex ventricular arrhythmias (multiform, couplets, or runs) as assessed by 48-hour Holter monitoring in 74 stable long-term hemodialysis patients (44.5±12 years old; 54% men; 74% whites; dialysis duration, 51.3±36.1 months; systolic pressure, 146.6±19.3 mm Hg; diastolic 89.2±12.1 prevalence arterial hypertension, 33.8%). Systolic pressures represented average all predialysis determinations during 3 months...
We validated a strategy for diagnosis of coronary artery disease (CAD) and prediction cardiac events in high-risk renal transplant candidates (at least one the following: age > or =50 years, diabetes, cardiovascular disease).A risk assessment was used 228 to validate an algorithm. Patients underwent dipyridamole myocardial stress testing angiography were followed up until death, transplantation, events.The prevalence CAD 47%. Stress did not detect significant 1/3 patients. The sensitivity,...
Abstract Background Cardiovascular mortality is increased in chronic kidney disease, a condition with high prevalence of periodontal disease. Whether periodontitis treatment improves prognosis unknown. Methods The effect on the incidence cardiovascular events and death 206 waitlist hemodialysis subjects was compared that 203 historical controls who did not undergo treatment. Patients were followed up for 24 months or until transplantation. Results moderate/severe 74%. Coronary artery disease...
Background. Age, diabetes and concomitant cardiovascular disease, recorded at the initiation of dialysis, allows identification patients with a high probability early mortality. When all these factors are taken into account mortality rate dialysis is still 3.5 times higher than for general population. Information on that increase lacking major risk important because likely to be correctable, especially if detected early. Methods. We investigated prospectively relevance blood pressure other...