A5032326208- Parathyroid Disorders and Treatments
- Bone health and treatments
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Pharmacological Effects and Toxicity Studies
- Genetic Syndromes and Imprinting
- Dialysis and Renal Disease Management
- Magnesium in Health and Disease
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Trace Elements in Health
- Thyroid and Parathyroid Surgery
- Medical Imaging and Pathology Studies
- Iron Metabolism and Disorders
- Folate and B Vitamins Research
- Aluminum toxicity and tolerance in plants and animals
- Growth Hormone and Insulin-like Growth Factors
- Dermatological and Skeletal Disorders
- Bone fractures and treatments
- Heterotopic Ossification and Related Conditions
- Body Composition Measurement Techniques
- Dental Implant Techniques and Outcomes
- Therapeutic Uses of Natural Elements
- Bone and Dental Protein Studies
- Biomedical Research and Pathophysiology
Universidade de São Paulo
2016-2025
Universidade Federal do Paraná
2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2007-2024
Universidade Cidade de São Paulo
2024
Universidade Brasil
2001-2024
Hospital de Clínicas
2021
RELX Group (United States)
2021
RELX Group (Netherlands)
2021
Sociedade de Nefrologia do Estado de São Paulo
2011-2020
Hospital Samaritano de São Paulo
2018-2019
Levels of parathyroid hormone (PTH) and the phosphaturic FGF23, a fibroblast growth factor (FGF) family member, increase early in chronic kidney disease (CKD) before occurrence hyperphosphatemia. This short-term 6-wk dose titration study evaluated effect two phosphate binders on PTH FGF23 levels patients with CKD stages 3 to 4.
Abstract Chronic kidney disease–mineral bone disorder (CKD-MBD) is defined by abnormalities in mineral and hormone metabolism, histomorphometric changes, and/or the presence of soft-tissue calcification. Emerging evidence suggests that features CKD-MBD may occur early disease progression are associated with changes osteocyte function. To identify bone, we utilized jck mouse, a genetic model polycystic exhibits progressive renal disease. At 6 weeks age, mice have normal function no but...
Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. Gremlin, a antagonist, is expressed in osteoblasts opposes effects on osteoblastic differentiation function vitro. However, its vivo are not known. To investigate the actions of gremlin remodeling vivo, we generated transgenic mice overexpressing under control osteocalcin promoter. Gremlin transgenics exhibited fractures reduced mineral density by 20–30%, compared with controls. Static dynamic histomorphometry...
<i>Background</i><i>and Aims:</i> Calcium-containing phosphate binders have been shown to increase the progression of vascular calcification in hemodialysis patients. This is a prospective study that compares effects calcium acetate and sevelamer on coronary (CAC) bone histology. <i>Methods:</i> 101 patients were randomized for each binder submitted multislice tomographies biopsies at entry 12 months. <i>Results:</i> The 71 who concluded had...
Fibroblast growth factor 23 (FGF-23) has emerged as a new in mineral metabolism chronic kidney disease (CKD). An important regulator of phosphorus homeostasis, FGF-23 been shown to independently predict CKD progression nondiabetic renal disease. We analyzed the relation between and outcome diabetic nephropathy (DN).DN patients participating clinical trial (enalapril+placebo versus enalapril+losartan) had baseline data collected were followed until June 2009 or primary was reached. Four lost...
Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. Noggin is a glycoprotein that binds BMPs selectively antagonizes actions. expression in osteoblasts induced by noggin opposes the effects of on osteoblastic differentiation function vitro. However, its vivo are not known. We investigated direct remodeling transgenic mice overexpressing under control osteocalcin promoter. transgenics suffered long fractures first month life. Total, vertebral, femoral mineral...
Objective: This study aimed to compare the consequences of low-level laser therapy (LLLT) and low-intensity pulsed ultrasound (LIPUS) on bone repair. Background Data: Many studies have assessed effects LLLT LIPUS repair, but a comparison them is rare. Methods: Male Wistar rats (n = 48) with tibial osteotomy were used. One group had osteotomized limb treated (GaAlAs laser, 780 nm, 30 mW, 112.5 J/cm2) second (1.5 MHz, mW/cm2), both for 12 sessions (five times per week); third was control....
Background and objectives Secondary hyperparathyroidism (SHPT) in CKD is associated with an increased risk for mortality, but definitive data showing that parathormone control decreases mortality still lacking. This study aimed to compare the of patients severe SHPT submitted parathyroidectomy(PTX) those who did not have access surgery. Methods a retrospective cohort 251 were referred CKD-MBD Center PTX from 2005 until 2012. Results Most our had indication PTX, only 49% them this surgical...
Sclerostin (Scl) has recently emerged as a novel marker of bone remodeling and vascular calcification. However, whether high circulating Scl is also risk factor for death not well established. The purpose this study was to test serum would be associated with mortality. we measured in hemodialysis patients' cohort, which followed during ten-year period. Competing regression models were applied, the follow-up, patients exposed both events kidney transplant death. Ninety-one aged 42.3 ± 18.8...
High serum phosphorus levels have been associated with mortality and cardiovascular events in patients chronic kidney disease the general population. In addition, high shown to induce vascular calcification endothelial dysfunction vitro. The aim of this study was evaluate relation coronary atherosclerosis setting normal renal function. This a cross-sectional involving 290 suspected artery undergoing elective angiography, creatinine clearance >60 ml/min/1.73 m2. Coronary obstruction assessed...
X-linked hypophosphatemia (XLH) is characterized by impaired renal tubular reabsorption of phosphate owing to increased circulating FGF23 levels, resulting in rickets growing children and bone mineralization. Increased decreases brush border membrane sodium-dependent transporter IIa (Npt2a) causing wasting, impairs 1-α hydroxylation 25-hydroxyvitamin D, induces the vitamin D 24-hydroxylase, leading inappropriately low levels 1,25-dihydroxyvitamin (1,25D). The goal therapy prevention...
The prevalence of aluminum (Al) intoxication has declined over the past 3 decades. However, different groups still report on diagnosis Al in bone. Prolonged and low-intensity exposures to may not be captured by serum measurements, preventing its proper diagnosis. We hypothesize that bone accumulation related cardiovascular events current Era.To detect accumulation; explore consequences accumulation.This is a sub-analysis Brazilian Registry Bone Biopsy, prospective, multicentre cohort, with...