A5021840545- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Bipolar Disorder and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Frailty in Older Adults
- Autopsy Techniques and Outcomes
- Cardiovascular Health and Disease Prevention
- Neurological Disorders and Treatments
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Nutrition and Health in Aging
- Health, Environment, Cognitive Aging
- Cerebrovascular and genetic disorders
- Genetics and Neurodevelopmental Disorders
- Infrared Thermography in Medicine
- Pharmacological Effects and Toxicity Studies
Universidade de São Paulo
2015-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2013-2024
Erasmus MC
2021
United States Nuclear Regulatory Commission
2021
Medical University of Vienna
2021
Erasmus University Rotterdam
2021
Bank of Brazil
2021
Tokyo Institute of Psychiatry
2013-2016
University of Würzburg
2016
University Memory and Aging Center
2011-2016
Rationale: There are no reports of the systemic human pathology novel swine H1N1 influenza (S-OIV) infection.Objectives: The autopsy findings 21 Brazilian patients with confirmed S-OIV infection presented. These died in winter southern hemisphere 2009 pandemic, acute respiratory failure.Methods: Lung tissue was submitted to virologic and bacteriologic analysis real-time reverse transcriptase polymerase chain reaction electron microscopy. Expression toll-like receptor (TLR)-3, IFN-γ, tumor...
Alzheimer's disease (AD) progression follows a specific spreading pattern, emphasizing the need to characterize those brain areas that degenerate first. The brainstem's locus coeruleus (LC) is first area develop neurofibrillary changes (neurofibrillary tangles [NFTs]).The methods include unbiased stereological analyses in human brainstems estimate LC volume and neuronal population controls individuals across all AD stages.As Braak stage increases by 1 unit, decreases 8.4%. Neuronal loss...
Alzheimer's disease (AD) is a severe neurodegenerative disorder still in search of effective methods diagnosis. Altered levels the NMDA receptor co-agonist, d-serine, have been associated with neurological disorders, including schizophrenia and epilepsy. However, whether d-serine are deregulated AD remains elusive. Here, we first measured D-serine post-mortem hippocampal cortical samples from nondemented subjects (n=8) patients (n=14). We next determined experimental models AD, wild-type...
Clarifying the relationships between neuropsychiatric symptoms and Alzheimer’s disease (AD)-related pathology may open avenues for effective treatments. Here, we investigate odds of developing across increasing burdens neurofibrillary tangle amyloid-β pathology. Participants who passed away 2004 2014 underwent comprehensive neuropathologic evaluation at Biobank Aging Studies from Faculty Medicine University São Paulo. Postmortem interviews with reliable informants were used to collect...
<h3>Objective:</h3> We conducted a clinicopathologic study in large population with very low levels of education to determine whether few years could contribute cognitive reserve and modify the relation neuropathologic indices dementia. <h3>Methods:</h3> In this cross-sectional study, we included 675 individuals 50 age or older from Brazilian Aging Brain Study Group. Cognitive abilities were evaluated through structured interview an informant at time autopsy, including Clinical Dementia...
Sex differences in the human olfactory function reportedly exist for sensitivity, odorant identification and memory, tasks which odors are rated based on psychological features such as familiarity, intensity, pleasantness, others. Which might be neural bases these behavioral differences? The number of cells regions, especially neurons, may represent a more accurate indicator machinery than volume or weight, but besides gross measures bulb, no systematic study sex absolute has yet been...
Background Clinicopathological studies are important in determining the brain lesions underlying dementia. Although almost 60% of individuals with dementia live developing countries, few clinicopathological focus on these individuals. We investigated frequency neurodegenerative and vascular-related neuropathological 1,092 Brazilian admixed older adults, their correlation cognitive neuropsychiatric symptoms, accuracy subtype diagnosis. Methods findings In this cross-sectional study, we...
Abstract Dementia is more prevalent in Blacks than Whites, likely due to a combination of environmental and biological factors. Paradoxically, clinical studies suggest an attenuation APOE ε4 risk dementia African ancestry (AFR), but dearth neuropathological data preclude the interpretation factors underlying these findings, including association between Alzheimer’s disease (AD) pathology, most frequent cause dementia. We investigated interaction ancestry, AD-related neuropathology, genotype...
Abstract Background and Objectives Modern diagnostic methods such as near‐infrared Raman spectroscopy (NIRS) allow quantification evaluation of human atherosclerotic lesions, which can be useful in diagnosing coronary artery disease. The objective the present study is to obtain feasible information detect atheromatous plaque using NIRS combined with discriminant analysis. Study Design/Material Methods An 830 nm Ti: sapphire laser pumped by an argon provides excitation. A spectrograph...
Argyrophilic grain disease (AGD) is a frequent late-onset, 4-repeat tauopathy reported in Caucasians with high educational attainment. Little known about AGD non-Caucasians or those low We describe demographics, clinical, and neuropathological features multiethnic cohort of 983 subjects ≥50 years age from São Paulo, Brazil. Clinical data were collected through semistructured interviews an informant included the Informant Questionnaire on Cognitive Decline Elderly, Dementia Rating,...
Previous evidence linking diabetes to Alzheimer's disease (AD) neuropathology is mixed and scant data are available from low- middle-income countries.To investigate the association between AD in a large autopsy study of older Brazilian adults.In this cross-sectional study, was defined by diagnosis during life or use antidiabetic medication. A standardized neuropathological examination performed using immunohistochemistry. The associations with Consortium Establish Registry for Alzheimer...
Abstract Introduction Education, and less frequently occupation, has been associated with lower dementia risk in studies from high‐income countries. We aimed to investigate the association of cognitive impairment education occupation a low‐middle‐income country sample. Methods In this cross‐sectional study, function was assessed by Clinical Dementia Rating sum boxes (CDR‐SOB). investigated complexity CDR‐SOB using adjusted linear regression models for age, sex, neuropathological lesions....
Fourier-transform (FT)-Raman spectroscopy has been used for identification and evaluation of human artherosclerotic lesions, providing biochemical information on arteries. In this work, fragments carotid arteries postmortem were analyzed using a FT-Raman spectrometer operating at an excitation wavelength 1064 nm, power 200 mW, spectral resolution 4 cm–1. A total 75 spectroscopically scanned results compared with histopathology. Discriminant analysis Mahalanobis distance was applied over...
Abstract The diagnosis of normal cognition or dementia in the Brazilian Brain Bank Aging Study Group (BBBABSG) has relied on postmortem interview with an informant. Objectives: To ascertain sensitivity and specificity based informant compared against established at a memory clinic. Methods: A prospective study was conducted BBBABSG Reference Center for Cognitive Disorders (RCCD), specialized clinic Hospital das Clínicas, University São Paulo Medical School. Control subjects cognitively...
OBJECTIVES:To assess the distribution of dementia subtypes in Brazil using a population-based clinicopathological study.METHOD: Brains from deceased individuals aged $50 years old were collected after next kin signed an informed consent form and provided information through standardized questionnaires.Post-mortem clinical diagnoses established consensus meetings, only cases with moderate or severe without cognitive impairment included analysis.Immunohistochemical neuropathological...
Raman spectroscopy has been employed to discriminate between malignant (basal cell carcinoma [BCC] and melanoma [MEL]) normal (N) skin tissues in vitro, aimed at developing a method for cancer diagnosis.Raman is an analytical tool that could be used diagnose rapidly noninvasively.Skin biopsy fragments of ≈ 2 mm(2) from excisional surgeries were scanned through spectrometer (830 nm excitation wavelength, 50 200 mW power, 20 sec exposure time) coupled fiber optic probe. Principal component...
Previous studies in dementia epidemiology have reported higher Alzheimer's disease rates African-Americans when compared with White Americans. To determine whether genetically determined African ancestry is associated neuropathological changes commonly dementia, we analyzed a population-based brain bank the highly admixed city of São Paulo, Brazil. was estimated through use previously described ancestry-informative markers. Risk presence neuritic plaques, neurofibrillary tangles, small...
The relationship between soccer and chronic traumatic encephalopathy (CTE) is not well established. We report clinicopathological correlations in an 83-year-old retired center-back player, with no history of concussion, manifesting typical Alzheimer-type dementia. Examination revealed mixed pathology including widespread CTE, moderate Alzheimer's disease, hippocampal sclerosis, TDP-43 proteinopathy. This case adds to a few CTE cases described players. Furthermore, it corroborates that may...
This study investigated for the first time genomewide DNA methylation changes of noncoding RNA genes in temporal cortex samples from individuals with Alzheimer’s disease (AD). The methylome 10 AD and age-matched controls were obtained using Illumina 450 K array. A total 2,095 among 15,258 interrogated CpG sites presented differential methylation, 161 which associated miRNA genes. In particular, that found to be hypermethylated compared control brains represent transcripts have been...
Many studies have been conducted to evaluate the association between air pollution and adverse health effects using a wide variety of methods assess exposure. However, assessment individual long-term exposure ambient is challenging task has not evaluated in large autopsy study. Our goal was investigate whether urban associated degree lung anthracosis, considering modifying factors such as personal habits, mobility patterns occupational activities. We study Sao Paulo, Brazil from February...
Background Inflammation of the perivascular adipose tissue (PvAT) may be related to atherosclerosis; however, association polarized macrophages in pericoronary PvAT with measurements atherosclerosis components humans has not been fully investigated. Methods and Results Coronary arteries were dissected surrounding PvAT. We evaluated percentage arterial obstruction, intima-media thickness, fibrous cap plaque components, number vasa vasorum. The proinflammatory (M1) anti-inflammatory (M2)...