A5070510031- Air Quality and Health Impacts
- Advanced Statistical Methods and Models
- Climate Change and Health Impacts
- Optimal Experimental Design Methods
- Air Quality Monitoring and Forecasting
- Autopsy Techniques and Outcomes
- Health disparities and outcomes
- Noise Effects and Management
- Heavy metals in environment
- Global Public Health Policies and Epidemiology
- Multi-Criteria Decision Making
- Global Cancer Incidence and Screening
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Statistical Methods and Inference
- Environmental Justice and Health Disparities
- Fuzzy Systems and Optimization
- Atrial Fibrillation Management and Outcomes
- Healthcare Regulation
- Radioactivity and Radon Measurements
- Cardiac Arrest and Resuscitation
- Urban Transport and Accessibility
- Water Quality and Pollution Assessment
- Maternal and Neonatal Healthcare
- Cardiovascular Syncope and Autonomic Disorders
- Urban Heat Island Mitigation
Universidade de São Paulo
2013-2024
Czech Academy of Sciences, Institute of Mathematics
2006-2022
Santa Rosa Memorial Hospital
2019
Centre Hospitalier Universitaire de Tours
2017-2018
Institute of Mathematics and Informatics
2006-2018
Association Francaise contre les Myopathies
2014
Brazilian Society of Computational and Applied Mathematics
2000-2013
Universidade Vale do Rio Doce
2004
The individual’s socioeconomic conditions are the most relevant to predict quality of someone’s health. However, such information is not usually found in medical records, making studies area difficult. Therefore, it common use composite indices that characterize a region socioeconomically, as Human Development Index (HDI). main advantage HDI its understanding and adoption on global scale. applicability limited for health since longevity dimension presents mathematical redundancy regression...
Many studies have been conducted to evaluate the association between air pollution and adverse health effects using a wide variety of methods assess exposure. However, assessment individual long-term exposure ambient is challenging task has not evaluated in large autopsy study. Our goal was investigate whether urban associated degree lung anthracosis, considering modifying factors such as personal habits, mobility patterns occupational activities. We study Sao Paulo, Brazil from February...
Abstract Autopsy continues to play an essential role in monitoring opportunistic fungal infections. However, few studies have analysed the historical trends of infections autopsies. Here, we analyse available data on obtained from autopsy reports during 85 years autopsies performed by largest service Brazil. All invasive presented between 1930 and 2015 were included. Of 158,404 analysed, 1096 involved In general, paracoccidioidomycosis (24%) was most frequent infection, followed candidiasis...
Background The effects of outdoor air pollution on lung function in adults are still controversial. Objective Evaluate the exposure to different levels traffic-generated PM2.5 workers' functions São Paulo, Brazil. Methods To cover a wide range exposures, 101 non-smoking workers from three occupations (taxi drivers, traffic controllers, and forest rangers) were selected for study. After clinical evaluation, participants scheduled attend four consecutive weekly visits which they received...
In this study, the effects of aerobic exercise on upper airways and their defense mechanisms were investigated in athletes. The athletes ran two different environments: downtown streets city São Paulo (Street), more polluted, an urban forest (Forest), less polluted. Thirty-eight young healthy for 45 min d−1 randomly during five consecutive days, with interval 48 h before changing environment. Clinical parameters respiratory tract markers evaluated after first run Mondays (1 d) Fridays (5 d)....
The analysis of chemical elements in the barks trees is an alternative procedure to access spatial heterogeneity traffic related air pollution. However, role tree species characterization variability airborne pollution poorly known. We present observational study conducted São Paulo, Brazil, based on 498 from three common species: Tipuana tipu, Poincianella pluviosa and Ligustrum sp.. considered ANCOVA models compare concentrations Al, Fe, Zn, Cu, Mn, Ba S bark located close streets with...
The characterisation of individual exposure to air pollution in urban scenarios is a challenge environmental epidemiological studies. We investigated if the city's monitoring stations over or underestimate individuals depending on their socioeconomic conditions and daily commuting times.The amount black carbon accumulated lungs 604 deceased who underwent autopsy São Paulo was considered as proxy for PM10. concentrations PM10 residence were estimated by interpolating an ordinary kriging...
To utilize low-cost and simple methods to assess airway lung inflammation biomarkers related air pollution.
The accumulation of detectable amounts radon progeny in human tissues may be a risk factor for development and progression chronic diseases. In this preliminary study, we analyzed the levels alpha-emitting Polonium-210 (210Po) olfactory epithelium, bulb, frontal lobe, lung cadavers from city Sao Paulo, SP, Brazil. We also assessed association between 210Po exposure parameters urban air pollution using linear regression models adjusted age, sex, smoke, time living daily commuting,...
Measurements of optical reflectance in passive filters impregnated with a reactive chemical solution may be transformed to ozone concentrations via calibration curve and constitute low cost alternative for environmental monitoring, mainly estimate human exposure. Given the possibility errors caused by exposure bias, it is common consider sets m exposed during certain period latent on n different sample occasions at location. Mixed models as random effects are useful analyze data obtained...
<i>Aims:</i> To evaluate cardiac arrhythmias and rhythm disturbances on 24 h ambulatory electrocardiographic monitoring in a cohort of asymptomatic healthy individuals with normal clinical examination. <i>Methods Results:</i> 625 individuals, the age range 15–83 (mean 42, SD 11.9) years; 276 (44.2%) men 349 (55.8%) women were submitted to 24-hour monitoring. Statistical analysis was performed likelihood ratio test automatic backward logistic regression. The frequency...
Heavy metals are natural and essential elements of the environment living beings, produced from (e.g. volcanic activity cosmic ray-induced spallation) anthropogenic processes industrial fossil fuel combustion). High-concentrations heavy radionuclides also originated activities in urban areas. In this preliminary study, we analyzed levels Polonium-210 (210Po) lung tissues autopsies residents city Sao Paulo, SP, Brazil. order to identify link among sources lungs, factor analysis was performed....
Amaro N. Duarte-Neto1Maria de Fátima Marinho2Lucia P. Barroso3Carmen D. Saldiva André3*Luiz Fernando F. da Silva1Marisa Dolhnikoff1Paulo Afonso André1Catia M. Minto4Catia S. Moura1Thábata Leite1Jair Theodoro Filho1Renata Aparecida Almeida Monteiro1Philip Setel5Martin W. Bratschi5Robert Mswia5Paulo Hilário Saldiva1Ana Luiza Bierrenbach2
Accurate cause of death data are essential to guide health policy. However, mortality surveillance is limited in many low-income countries. In such settings, verbal autopsy (VA) increasingly used provide population-level data. VAs now widely interpreted using the automated algorithms SmartVA and InterVA. Here we use conventional as gold standard validate methodology.This study included adult deaths from natural causes São Paulo Recife for which was indicated. VA conducted with a relative...
This paper concerns the minimum sum of absolute errors regression. It is a more robust alternative to popular least squares regression whenever there are outliers in values response variable, or follow long tailed distribution, loss function proportional rather than their squared values. We use data from study interstitial lung disease illustrate method, interpret findings, and contrast with point out some problems analysis show how avoid these analysis. Copyright © 1999 John Wiley & Sons, Ltd.
Background and Objectives: Olesoxime (TRO19622) was identified as a potential treatment of spinal muscular atrophy (SMA) based on its beneficial effects in multiple preclinical neurodegeneration models. promotes neuron survival, neurite outgrowth, recovery from nerve injury accelerates myelination or remyelination models demyelinating diseases. Maintaining motor architecture survival is highly relevant to SMA, disease associated with progressive compromise mainly affecting neuromuscular...