A5026317118- Parathyroid Disorders and Treatments
- Bone health and treatments
- Aluminum toxicity and tolerance in plants and animals
- Magnesium in Health and Disease
- Bone fractures and treatments
- Nutrition and Health in Aging
- Bone health and osteoporosis research
- Diabetes Treatment and Management
- Neurological and metabolic disorders
- Hypertrophic osteoarthropathy and related conditions
- Heavy Metal Exposure and Toxicity
- Therapeutic Uses of Natural Elements
- Healthcare Regulation
- Chronic Kidney Disease and Diabetes
- Vitamin D Research Studies
- Eosinophilic Disorders and Syndromes
- Autopsy Techniques and Outcomes
- Viral Infections and Immunology Research
- Dialysis and Renal Disease Management
- Dermatological and Skeletal Disorders
- Heart Failure Treatment and Management
- Immunodeficiency and Autoimmune Disorders
- Genetic Syndromes and Imprinting
- Medical Imaging and Pathology Studies
- Cardiovascular Function and Risk Factors
Universidade Estadual de Campinas (UNICAMP)
2017-2024
GTx (United States)
2023
Creighton University
2023
American Society of Nephrology
2018
The prevalence of aluminum (Al) intoxication has declined over the past 3 decades. However, different groups still report on diagnosis Al in bone. Prolonged and low-intensity exposures to may not be captured by serum measurements, preventing its proper diagnosis. We hypothesize that bone accumulation related cardiovascular events current Era.To detect accumulation; explore consequences accumulation.This is a sub-analysis Brazilian Registry Bone Biopsy, prospective, multicentre cohort, with...
Mineral and bone disorders (MBD) are major complications of chronic kidney disease (CKD)-related adverse outcomes. The Brazilian Registry Bone Biopsy (REBRABO) is an electronic database that includes renal osteodystrophy (RO) data. We aimed to describe the epidemiological profile RO in a sample CKD-MBD patients understand its relationship with
Abstract Introduction: The epidemiologic profile of renal osteodystrophy (ROD) is changing over time and cross-sectional studies provide essential information to improve care health policies. Brazilian Registry Bone Biopsy (REBRABO) a prospective, nationalmulticenter cohort that includes patients with chronic kidney disease (CKD) undergoing bone biopsy. REBRABO aims clinical on ROD. main objective this subanalysis was describe the ROD, including clinically relevant associations. Methods:...
Abstract Background: Patients with chronic kidney disease (CKD) are affected by dynapenia, sarcopenia, and vascular calcification. Advanced glycation end products (AGEs) may accumulate in peritoneal dialysis (PD) patients favor sarcopenia via changes collagen cross-linking, muscle protein breakdown, the calcification of arterial smooth cells p38-MAPK activation. The aim this study is to explore relationships between AGEs, degeneration, coronary artery Methods: This was a clinical...
ABSTRACT About four decades ago, the relationship between dialysis-dementia and aluminum (Al) began to be established. The restriction of drugs containing Al improvements on water quality used for dialysis resulted in clinical disappearance intoxication. However, high prevalence deposition bone tissue from Brazilian patients is still being detected. Through case report a patient hemodialysis (HD) one year, presenting significant tissue, we speculated if this problem not underestimated. We...
Abstract Introduction: Renal osteodystrophy (ROD) refers to a group of bone morphological patterns that derive from distinct pathophysiological mechanisms. Whether the ROD subtypes influence long-term outcomes is unknown. Our objective was explore relationship between and clinical outcomes. Methods: This study subanalysis Brazilian Registry Bone Biopsies (REBRABO). Samples individual patients were classified as having osteitis fibrosa (OF), mixed uremic (MUO), adynamic disease (ABD),...
Abstract Background and Aims Mineral bone disorders caused by chronic kidney disease (CKD-MBD) encompass biochemical/hormonal abnormalities, soft tissue calcifications morphological changes known as renal osteodystrophy (ROD). Data from prior studies have consistently shown that patients with CKD-MBD are susceptible to an increased risk of mortality, fractures major cardiovascular outcomes. This study is a sub analysis the Brazilian Registry Bone Biopsy (REBRABO), prospective, national...
Background Dapagliflozin prevents myocardial dysfunction in chronic kidney disease patients regardless of residual function. We hypothesized that this effect is extensible also to on dialysis.
Abstract Background and Aims Acute Kidney Injury (AKI) is a syndrome characterized by an abrupt drop in glomerular filtration and/or decrease urinary output. The awakening to different kind of AKI that also occurs outside the hospital named community-acquired (CA-AKI) occurred 1991, however, few data have been published about its epidemiology, risk factors outcome, especially low-income countries. recognition for CA-AKI development symptom-based tool aims predict might be able avoid delays...
Resumo Introdução: O perfil epidemiológico da osteodistrofia renal (OR) está mudando com o tempo e estudos transversais fornecem informações essenciais para melhorar cuidados políticas de saúde. Registro Brasileiro Biópsia Óssea (REBRABO) é uma coorte nacional multicêntrica prospectiva que inclui pacientes doença crônica (DRC) submetidos à biópsia óssea. REBRABO visa fornecer clínicas sobre OR. principal objetivo desta subanálise foi descrever OR, incluindo associações clinicamente...
Abstract Purpose. Sodium glucose co-transporter 2 inhibitors (SGLT2i) remarkably reduced the incidence of hospitalization for heart failure and cardiovascular death conservatively managed chronic kidney disease. We hypothesized that adding SGLT2i to standard treatment would yield benefits also in end-stage disease (ESKD) individuals on dialysis. Methods. The DARE-ESKD-2 Trial (NCT05685394) is an ongoing, single-center, open-label, controlled trial aimed at assessing effects dapagliflozin...
Resumo Introdução: Osteodistrofia renal (OR) refere-se a um grupo de padrões morfológicos ósseos que decorrem mecanismos fisiopatológicos distintos. É desconhecido se os subtipos OR influenciam desfechos em longo prazo. Nosso objetivo foi explorar as relações entre e desfechos. Métodos: Este estudo é uma subanálise do Registro Brasileiro Biópsias Ósseas (REBRABO). As amostras cada paciente foram classificadas osteíte fibrosa (OF), osteodistrofia urêmica mista (MUO), doença óssea adinâmica...
We conducted a prospective observational cohort study of Community Acquired AKI in patients treated Department Nephrology, Postgraduate Institute Medical Education and Research, Chandigarh.CA-AKI was defined as presumed to be due primary disease or factor acquired the community before health care services contact.Patients with evidence underlying CKD, cirrhosis, Heart failure (NYHA 3 4), malignancy, urinary tract obstruction were excluded.Patients followed up at discharge, one four months...
A doença cardiovascular (DCV) é a principal causa de mortalidade em pacientes com renal crônica (DRC). sarcopenia, por sua vez, prevalente nesse grupo e está associada à ocorrência complicações cardiovasculares. Os produtos da glicação avançada (AGEs), tipos toxinas urêmicas, parecem estar relacionados sarcopenia. Recentemente foi desenvolvida uma técnica não invasiva para avaliar deposição tecidual AGEs através autofluorescência pele (AF). Objetivo: quantificar AF DRC diálise peritoneal...
ABSTRACT Introduction Epidemiologic profile of renal osteodystrophy (ROD) is changing over time and cross-sectional studies provide essential information to improve care health policies. The Brazilian Registry Bone Biopsy (REBRABO) a prospective, national-multicenter cohort that aims clinical on ROD. Methods From Aug/2015-Dec/2021, clinical-demographic, laboratory ROD were included. Results Data from 386 individuals considered. Age was 52 (42–60) years; 198 (51%) male; 315 (82%)...