A5064259258- Adipose Tissue and Metabolism
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Microbial Metabolic Engineering and Bioproduction
- Consumer Market Behavior and Pricing
- Viral Infectious Diseases and Gene Expression in Insects
- Gene Regulatory Network Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Consumer Behavior in Brand Consumption and Identification
- Bacterial Genetics and Biotechnology
- Fatty Acid Research and Health
- Heat shock proteins research
- Diet, Metabolism, and Disease
- Digital Marketing and Social Media
- Connexins and lens biology
- Biosimilars and Bioanalytical Methods
- Protein purification and stability
- Wine Industry and Tourism
- RNA Research and Splicing
- Pancreatic function and diabetes
- Nitric Oxide and Endothelin Effects
- Customer Service Quality and Loyalty
- Fungal and yeast genetics research
- Circadian rhythm and melatonin
Boehringer Ingelheim (Germany)
2023
Daimler (Germany)
2020
University of Stuttgart
2014-2017
University of Salzburg
1999-2017
Yale University
2009-2012
Medical University of Vienna
2005-2007
Austrian Academy of Sciences
2006
Karlsruhe Institute of Technology
1998
Munich University of Applied Sciences
1969
Insulin stimulates glucose uptake in fat and muscle by redistributing GLUT4 transporters from intracellular membranes to the cell surface. We previously proposed that, 3T3-L1 adipocytes, TUG retains within unstimulated cells insulin mobilizes this retained stimulating its dissociation TUG. Yet relative importance of action overall control remains uncertain. Here we report that transient, small interfering RNA-mediated depletion causes translocation enhances similar insulin. Stable or...
To promote glucose uptake into fat and muscle cells, insulin causes the translocation of GLUT4 transporters from intracellular vesicles to cell surface. Previous data support a model in which TUG traps GLUT4-containing tethers them intracellularly unstimulated cells mobilizes this pool by releasing tether. Here we show that undergoes site-specific endoproteolytic cleavage, separates GLUT4-binding, N-terminal region C-terminal previously suggested bind an anchor. Cleavage is accelerated...
Summary In large‐scale production processes, metabolic control is typically achieved by limited supply of essential nutrients such as glucose or ammonia. With increasing bioreactor dimensions, microbial producers Escherichia coli are exposed to changing substrate availabilities due mixing. turn, cells sense and respond these dynamic conditions leading frequent activation their regulatory programmes. Previously, we characterized short‐ long‐term strategies adapt fluctuations. Here, focused on...
Salicylaldoxime (2 x 10(-3)m and less) inhibits cyclic photophosphorylation in intact Chlorella cells severely whereas photosynthetic O(2)-evolution (14)CO(2)-fixation is hardly affected. Cyclic vivo was measured by following anaerobic light dependent glucose uptake. A similar difference susceptibility has been observed with carbonylcyanide-p-trifluoromethoxyphenylhydrazone. Various controls exclude the possibility that inhibition caused differing experimental conditions or, case of...
Rapidly changing concentrations of substrates frequently occur during large-scale microbial cultivations. These conditions, caused by large mixing times, result in a heterogeneous population distribution. Here, we present powerful and efficient modeling approach to predict the influence varying substrate levels on transcriptional translational response cell. This consists two parts, single-cell model describe transcription translation for an exemplary operon (trp operon) second part...
Agonists of the nuclear receptors peroxisome proliferator-activated receptor (PPAR) γ, PPARα, and liver X (LXRs) reduce blood glucose in type 2 diabetic patients comparable mouse models. Since capacity these drugs to normalize hepatic gene expression is not known, we compared groups obese <i>db/db</i> mice treated with agonists for PPARγ [rosiglitazone (Rosi); 10 mg/kg/day], PPARα [Wy 14643 (Wy; 4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thioacetic acid); 30 LXR [T0901317 (T09;...
Abstract Process intensification aims to increase productivity in biologics manufacturing. Significant progress has been made academia, the biopharmaceutical industry, and by regulatory guidance since 2000s. can include all unit operations of a drug substance manufacturing process. The applied upstream concepts have consequences on downstream process (DSP). DSP must manage larger product amounts while ensuring required quality impurity profiles, cope with available time frame as per...
Objectives: Inflammatory changes in white adipose tissue of obese individuals appear to be causally linked development insulin resistance and type 2 diabetes mellitus. Based on beneficial effects n-3 polyunsaturated fatty acids (PUFA) inflammatory responses development, we investigated possible PUFA inflammation diabetic mice.